The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Diverse NLR immune receptors activate defence via the RPW 8‐NLR NRG 1
Open accessAbstract
Summary: Most land plant genomes carry genes that encode RPW 8‐NLR Resistance (R) proteins. Angiosperms carry two RPW 8‐NLR subclasses: ADR 1 and NRG 1. ADR 1s act as ‘helper’ NLR s for multiple TIR‐ and CC‐NLR R proteins in Arabidopsis. In angiosperm families, NRG 1 co‐occurs with TIR‐NLR Resistance (R) genes. We tested whether NRG 1 is required for signalling of multiple TIR‐NLR s. Using CRISPR mutagenesis, we obtained an nrg1a‐nrg1b double mutant in two Arabidopsis accessions, and an nrg1 mutant in Nicotiana benthamiana. These mutants are compromised in signalling of all TIR‐NLR s tested, including WRR 4A, WRR 4B, RPP 1, RPP 2, RPP 4 and the pairs RRS 1/RPS 4, RRS 1B/RPS 4B, CHS 1/SOC 3 and CHS 3/CSA 1. In Arabidopsis, NRG 1 is required for the hypersensitive cell death response (HR) and full oomycete resistance, but not for salicylic acid induction or bacterial resistance. By contrast, nrg1 loss of function does not compromise the CC‐NLR R proteins RPS 5 and MLA. RPM 1 and RPS 2 (CC‐NLR s) function is slightly compromised in an nrg1 mutant. Thus, NRG 1 is required for full TIR‐NLR function and contributes to the signalling of some CC‐NLR s. Some NRG 1‐dependent R proteins also signal partially via the NRG 1 sister clade, ADR 1. We propose that some NLR s signal via NRG 1 only, some via ADR 1 only and some via both or neither.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Self-citationEnzymatic assembly of DNA molecules up to several hundred kilobases
Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 9,996
20 years of the SMART protein domain annotation resource
Letunic, I., & Bork, P. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx922 · Cited by 2,020
Li, J.-F., Norville, J. E., Aach, J., McCormack, M., Zhang, D., Bush, J., Church, G. M., & Sheen, J. (2013) · Nature Biotechnology · doi:10.1038/nbt.2654 · Cited by 1,510
Mackey, D., Holt, B. F., Wiig, A., & Dangl, J. L. (2002) · Cell · doi:10.1016/s0092-8674(02)00661-x · Cited by 1,200
Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes
Engler, C., Gruetzner, R., Kandzia, R., & Marillonnet, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005553 · Cited by 1,023
Dong, X. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.07.005 · Cited by 845
Kourelis, J., & van der Hoorn, R. A. L. (2018) · The Plant Cell · doi:10.1105/tpc.17.00579 · Cited by 791
The Rx Gene from Potato Controls Separate Virus Resistance and Cell Death Responses
Bendahmane, A., Kanyuka, K., & Baulcombe, D. C. (1999) · The Plant Cell · doi:10.1105/tpc.11.5.781 · Cited by 717
Cited by
Thirty years of resistance: Zig-zag through the plant immune system
Ngou, B. P. M., Ding, P., & Jones, J. D. G. (2022) · The Plant Cell · doi:10.1093/plcell/koac041 · Cited by 961
Self-citationPTI-ETI crosstalk: an integrative view of plant immunity
Yuan, M., Ngou, B. P. M., Ding, P., & Xin, X.-F. (2021) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2021.102030 · Cited by 915
Self-citationReconstitution and structure of a plant NLR resistosome conferring immunity
Wang, J., Hu, M., Wang, J., Qi, J., Han, Z., Wang, G., Qi, Y., Wang, H.-W., Zhou, J.-M., & Chai, J. (2019) · Science · doi:10.1126/science.aav5870 · Cited by 850
A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors
Lapin, D., Kovacova, V., Sun, X., Dongus, J. A., Bhandari, D., von Born, P., Bautor, J., Guarneri, N., Rzemieniewski, J., Stuttmann, J., et al. (2019) · The Plant Cell · doi:10.1105/tpc.19.00118 · Cited by 303
Li, L., & Weigel, D. (2021) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-020620-114826 · Cited by 48
Metadata
- Authors
- Castel, B., Ngou, P., Cevik, V., Redkar, A., Kim, D., Yang, Y., Ding, P., & Jones, J. D. G.
- Venue
- New Phytologist
- Publisher
- Wiley
- Published
- 2019-01-25
- Volume
- 222
- Issue
- 2
- Pages
- 966-980
- ISSN
- 0028-646X (ISSN-L)
- 1469-8137
- OpenAlex
- W2906522235
- Cited by
- 267
- References
- 45
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Diverse NLR immune receptors activate defence via the RPW 8‐NLR NRG 1. https://app.cochat.ai/papers/10.1111/nph.15659
- The paper
- Castel, B., Ngou, P., Cevik, V., Redkar, A., Kim, D., Yang, Y., Ding, P., & Jones, J. D. G. (2019). Diverse NLR immune receptors activate defence via the RPW 8‐NLR NRG 1. New Phytologist. https://doi.org/10.1111/nph.15659
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
