The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cell volume change through water efflux impacts cell stiffness and stem cell fate
Open accessAbstract
Significance: Cell volume is thought to be a well-controlled cellular characteristic, increasing as a cell grows, while macromolecular density is maintained. We report that cell volume can also change in response to external physical cues, leading to water influx/efflux, which causes significant changes in subcellular macromolecular density. This is observed when cells spread out on a substrate: Cells reduce their volume and increase their molecular crowding due to an accompanying water efflux. Exploring this phenomenon further, we removed water from mesenchymal stem cells through osmotic pressure and found this was sufficient to alter their differentiation pathway. Based on these results, we suggest cells chart different differentiation and behavioral pathways by sensing/altering their cytoplasmic volume and density through changes in water influx/efflux.
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Citations
Cites
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Macromolecular crowding: obvious but underappreciated
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Water as an active constituent in cell biology
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Functional significance of cell volume regulatory mechanisms
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“This causes increased concentration of intracellular material and molecular crowding, having numerous important consequences (6, 7).”
BackgroundPhysiology of cell volume regulation in vertebrates
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Kinetics of Core Histones in Living Human Cells
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Cited by
The stiffness of living tissues and its implications for tissue engineering
Guimarães, C. F., Gasperini, L., Marques, A. P., & Reis, R. L. (2020) · Nature Reviews Materials · doi:10.1038/s41578-019-0169-1 · Cited by 1,515
Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 855
Brillouin microscopy: an emerging tool for mechanobiology
Prevedel, R., Diz-Muñoz, A., Ruocco, G., & Antonacci, G. (2019) · Nature Methods · doi:10.1038/s41592-019-0543-3 · Cited by 470
Janmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
Mechanochemical Feedback Loops in Development and Disease
Hannezo, E., & Heisenberg, C.-P. (2019) · Cell · doi:10.1016/j.cell.2019.05.052 · Cited by 353
Metadata
- Authors
- Guo, M., Pegoraro, A. F., Mao, A., Zhou, E. H., Arany, P. R., Han, Y., Burnette, D. T., Jensen, M. H., Kasza, K. E., Moore, J. R., Mackintosh, F. C., Fredberg, J. J., Mooney, D. J., Lippincott-Schwartz, J., & Weitz, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-09-25
- Volume
- 114
- Issue
- 41
- Pages
- E8618-E8627
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2759276314
- Cited by
- 529
- References
- 9
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Guo, M., Pegoraro, A. F., Mao, A., Zhou, E. H., Arany, P. R., Han, Y., Burnette, D. T., Jensen, M. H., Kasza, K. E., Moore, J. R., Mackintosh, F. C., Fredberg, J. J., Mooney, D. J., Lippincott-Schwartz, J., & Weitz, D. A. (2017). Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1705179114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
