The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
Open accessAbstract
Significance: This study provides a mechanistic explanation for the differentiation of trophoblasts from human pluripotent stem cells, a process relying on BMP morphogens. We found that a network of the transcription factors GATA2, GATA3, TFAP2A, and TFAP2C regulates early trophoblast progenitor specification by activating placental genes and inhibiting the pluripotency gene OCT4 , thus acting to couple trophoblast specification with exit from pluripotency. To demonstrate the relevance of our findings in vivo, we show that down-regulating GATA3 in primate embryos prevents trophectoderm specification. In addition, we present a genome-wide analysis of active and inactive chromatin during trophoblast progenitor specification. These results provide a basis to guide investigations of human trophectoderm development.
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
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Comparative Analysis of Single-Cell RNA Sequencing Methods
Ziegenhain, C., Vieth, B., Parekh, S., Reinius, B., Guillaumet-Adkins, A., Smets, M., Leonhardt, H., Heyn, H., Hellmann, I., & Enard, W. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.023 · Cited by 1,494
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Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
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Cited by
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Gao, L., Mathur, V., Tam, S. K. M., Zhou, X., Cheung, M. F., Chan, L. Y., Estrada-Gutiérrez, G., Leung, B. W., Moungmaithong, S., Wang, C. C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01169-x · Cited by 31
Uzbas, F., Opperer, F., Sönmezer, C., Shaposhnikov, D., Sass, S., Krendl, C., Angerer, P., Theis, F. J., Mueller, N. S., & Drukker, M. (2019) · Genome Biology · doi:10.1186/s13059-019-1748-6 · Cited by 23
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Metadata
- Authors
- Krendl, C., Shaposhnikov, D., Rishko, V., Ori, C., Ziegenhain, C., Sass, S., Simon, L., Müller, N. S., Straub, T., Brooks, K. E., Chavez, S. L., Enard, W., Theis, F. J., & Drukker, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-10-25
- Volume
- 114
- Issue
- 45
- Pages
- E9579-E9588
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2765099814
- Cited by
- 165
- References
- 10
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Krendl, C., Shaposhnikov, D., Rishko, V., Ori, C., Ziegenhain, C., Sass, S., Simon, L., Müller, N. S., Straub, T., Brooks, K. E., Chavez, S. L., Enard, W., Theis, F. J., & Drukker, M. (2017). GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1708341114
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