The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Open accessAbstract
Significance: Metabolic reprogramming is one of the hallmarks of cancer. However, the underlying mechanisms that regulate cancer metabolism are poorly understood. Here we performed multiomics-based analysis of paired normal–tumor tissues from patients with colorectal cancer, which revealed that the protooncogene protein MYC regulated global metabolic reprogramming of colorectal cancer by modulating 215 metabolic reactions. Importantly, this metabolic reprogramming occurred in a manner not associated with specific gene mutations in colorectal carcinogenesis. For many years, small-molecule or biologic inhibitors of MYC have been required. Here we demonstrate that knockdown of MYC downstream pyrimidine synthesis genes contributes to the suppression of colorectal cancer cell proliferation similar to MYC, and thus pyrimidine synthesis pathways could be potential targets for colorectal cancer therapy.
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Cites
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Cited by
Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654
Metabolic Pathways Regulating Colorectal Cancer Initiation and Progression
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Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
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Applications of metabolomics to study cancer metabolism
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NRF3 activates mTORC1 arginine-dependently for cancer cell viability
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Self-citation
Metadata
- Authors
- Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M. M., Kushida, Y., Haba, R., Okano, K., Tomita, M., Suzuki, Y., Fukuda, S., Aoki, M., & Soga, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-08-28
- Volume
- 114
- Issue
- 37
- Pages
- E7697-E7706
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2749296525
- Cited by
- 361
- References
- 34
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M. M., . . . Soga, T. (2017). Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1710366114
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