The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity
Open accessAbstract
Significance: Cancer immunotherapy is a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who have cancer. Although cells of the myeloid lineage frequently infiltrate tumors and limit therapeutic success, currently approved immunotherapies primarily target tumor-infiltrating T and natural killer lymphocytes. The inhibitory receptor signal regulatory protein-α (SIRPα) represents a myeloid-specific immune checkpoint that engages the “don’t eat me” signal CD47. Here, we developed an anti-human SIRPα antibody, KWAR23, which in combination with tumor-opsonizing antibodies, greatly augmented neutrophil and macrophage antitumor activity in vitro and in vivo. Thus, KWAR23 may represent a promising candidate for combination therapies and may achieve durable responses in a greater number of patients with cancer.
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Self-citationTumor-Associated Macrophages: Recent Insights and Therapies
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Metadata
- Authors
- Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.-P., George, B. M., Lietzenmayer, M., McKenna, K. M., Naik, T. J., McCarty, A., Zheng, Y., Ring, A. M., Flavell, R. A., & Weissman, I. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-11-20
- Volume
- 114
- Issue
- 49
- Pages
- E10578-E10585
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2770192040
- Cited by
- 283
- References
- 53
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J.-P., George, B. M., Lietzenmayer, M., McKenna, K. M., Naik, T. J., McCarty, A., Zheng, Y., Ring, A. M., Flavell, R. A., & Weissman, I. L. (2017). Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1710877114
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