The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats
Open accessAbstract
Royal College of Surgeons rats are genetically predisposed to undergo significant visual loss caused by a primary dysfunction of retinal pigment epithelial (RPE) cells. By using this model, we have examined the efficacy of subretinal transplantation of two independent human RPE cell lines each exhibiting genetic modifications that confer long-term stability in vitro . The two cell lines, a spontaneously derived cell line (ARPE19) and an extensively characterized genetically engineered human RPE cell line (h1RPE7), which expresses SV40 large T (tumor) antigen, were evaluated separately. Both lines result in a significant preservation of visual function as assessed by either behavioral or physiological techniques. This attenuation of visual loss correlates with photoreceptor survival and the presence of donor cells in the areas of rescued photoreceptors at 5 months postgrafting (6 months of age). These results demonstrate the potential of genetically modified human RPE cells for ultimate application in therapeutic transplantation strategies for retinal degenerative diseases caused by RPE dysfunction.
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Cites
Algvere, P. V., Berglin, L., Gouras, P., & Sheng, Y. (1994) · Graefe's Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00184273 · Cited by 346
Algvere, P. V., Berglin, L., Gouras, P., Sheng, Y., & Kopp, E. D. (1997) · Graefe's Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00941722 · Cited by 264
ALLOGENIC FETAL RETINAL PIGMENT EPITHELIAL CELL TRANSPLANT IN A PATIENT WITH GEOGRAPHIC ATROPY
WEISZ, J. M., HUMAYUN, M. S., JUAN, E. D., CERRO, M. D., SUNNESS, J. S., DAGNELIE, G., SOYLU, M., RIZZO, L., & NUSSENBLATT, R. B. (1999) · Retina · doi:10.1097/00006982-199919060-00011 · Cited by 5
Cited by
Lu, B., Malcuit, C., Wang, S., Girman, S., Francis, P., Lemieux, L., Lanza, R., & Lund, R. (2009) · Stem Cells · doi:10.1002/stem.149 · Cited by 470
Self-citationKlimanskaya, I., Hipp, J., Rezai, K. A., West, M., Atala, A., & Lanza, R. (2004) · Cloning and Stem Cells · doi:10.1089/clo.2004.6.217 · Cited by 437
Human Embryonic Stem Cell–Derived Cells Rescue Visual Function in Dystrophic RCS Rats
Lund, R. D., Wang, S., Klimanskaya, I., Holmes, T., Ramos-Kelsey, R., Lu, B., Girman, S., Bischoff, N., Sauvé, Y., & Lanza, R. (2006) · Cloning and Stem Cells · doi:10.1089/clo.2006.8.189 · Cited by 406
Self-citationMellough, C. B., Sernagor, E., Moreno-Gimeno, I., Steel, D. H. W., & Lako, M. (2012) · Stem Cells · doi:10.1002/stem.1037 · Cited by 162
Tomita, H., Sugano, E., Isago, H., Hiroi, T., Wang, Z., Ohta, E., & Tamai, M. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.12.006 · Cited by 148
Metadata
- Authors
- Lund, R. D., Adamson, P., Sauvé, Y., Keegan, D. J., Girman, S. V., Wang, S., Winton, H., Kanuga, N., Kwan, A. S. L., Beauchène, L., Zerbib, A., Hetherington, L., Couraud, P.-O., Coffey, P., & Greenwood, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-08-14
- Volume
- 98
- Issue
- 17
- Pages
- 9942-9947
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2134421016
- Cited by
- 189
- References
- 3
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Lund, R. D., Adamson, P., Sauvé, Y., Keegan, D. J., Girman, S. V., Wang, S., Winton, H., Kanuga, N., Kwan, A. S. L., Beauchène, L., Zerbib, A., Hetherington, L., Couraud, P.-O., Coffey, P., & Greenwood, J. (2001). Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.171266298
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
