The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of removing Kupffer cells on nanoparticle tumor delivery
Open accessAbstract
Significance: Nanomaterials are developed for treating and diagnosing cancer, but only 0.7% (median) are delivered to a solid tumor. To address this delivery problem, we are examining each biological barrier to determine its impact on tumor delivery. Because the liver sequesters up to 70% of nanomaterials, in this study, we asked, if liver Kupffer cells were removed, what is the impact on tumor delivery? While we demonstrate that the tumor delivery increased up to 150 times, we achieved 2% for nanomaterials of different size, material, and tumor type. This suggests the need to focus on tumor pathophysiology to increase delivery efficiency, since this approach led to a greater availability of nanoparticles in the blood, but 98% did not accumulate in solid tumors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Self-citation
Cited by
The entry of nanoparticles into solid tumours
Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732
Self-citationOvercoming the Reticuloendothelial System Barrier to Drug Delivery with a “Don’t-Eat-Us” Strategy
Tang, Y., Wang, X., Li, J., Nie, Y., Liao, G., Yu, Y., & Li, C. (2019) · ACS Nano · doi:10.1021/acsnano.9b05679 · Cited by 339
Advancing engineering design strategies for targeted cancer nanomedicine
Gomerdinger, V. F., Nabar, N., & Hammond, P. T. (2025) · Nature Reviews Cancer · doi:10.1038/s41568-025-00847-2 · Cited by 146
Periportal macrophages protect against commensal-driven liver inflammation
Miyamoto, Y., Kikuta, J., Matsui, T., Hasegawa, T., Fujii, K., Okuzaki, D., Liu, Y.-C., Yoshioka, T., Seno, S., Motooka, D., et al. (2024) · Nature · doi:10.1038/s41586-024-07372-6 · Cited by 135
Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery
Lokugamage, M. P., Gan, Z., Zurla, C., Levin, J., Islam, F. Z., Kalathoor, S., Sato, M., Sago, C. D., Santangelo, P. J., & Dahlman, J. E. (2020) · Advanced Materials · doi:10.1002/adma.201904905 · Cited by 126
Metadata
- Authors
- Tavares, A. J., Poon, W., Zhang, Y.-N., Dai, Q., Besla, R., Ding, D., Ouyang, B., Li, A., Chen, J., Zheng, G., Robbins, C., & Chan, W. C. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-12-05
- Volume
- 114
- Issue
- 51
- Pages
- E10871-E10880
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2772572314
- Cited by
- 286
- References
- 1
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of removing Kupffer cells on nanoparticle tumor delivery. https://app.cochat.ai/papers/10.1073/pnas.1713390114
- The paper
- Tavares, A. J., Poon, W., Zhang, Y.-N., Dai, Q., Besla, R., Ding, D., Ouyang, B., Li, A., Chen, J., Zheng, G., Robbins, C., & Chan, W. C. W. (2017). Effect of removing Kupffer cells on nanoparticle tumor delivery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1713390114
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
