Mild Innate Immune Activation Overrides Efficient Nanoparticle‐Mediated RNA Delivery

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · see citing works

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667 · see citing works

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

Adams, D., Gonzalez-Duarte, A., O’Riordan, W. D., Yang, C.-C., Ueda, M., Kristen, A. V., Tournev, I., Schmidt, H. H., Coelho, T., Berk, J. L., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716153 · Cited by 3,047 · see citing works

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283 · see citing works

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912 · see citing works

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758 · see citing works

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2612 · Cited by 1,681 · see citing works

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261 · see citing works

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,256 · see citing works

Physical Principles of Nanoparticle Cellular Endocytosis

Zhang, S., Gao, H., & Bao, G. (2015) · ACS Nano · doi:10.1021/acsnano.5b03184 · Cited by 1,148 · see citing works

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2614 · Cited by 948 · see citing works

Modified mRNA vaccines protect against zika virus infection

Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909 · see citing works

Assembly and localization of Toll-like receptor signalling complexes

Gay, N. J., Symmons, M. F., Gangloff, M., & Bryant, C. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3713 · Cited by 832 · see citing works

Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818 · see citing works

Tools for translation: non-viral materials for therapeutic mRNA delivery

Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799 · see citing works

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Wittrup, A., Ai, A., Liu, X., Hamar, P., Trifonova, R., Charisse, K., Manoharan, M., Kirchhausen, T., & Lieberman, J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3298 · Cited by 693 · see citing works

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

Kleffel, S., Posch, C., Barthel, S. R., Mueller, H., Schlapbach, C., Guenova, E., Elco, C. P., Lee, N., Juneja, V. R., Zhan, Q., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.052 · Cited by 648 · see citing works

Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses

Bahl, K., Senn, J. J., Yuzhakov, O., Bulychev, A., Brito, L. A., Hassett, K. J., Laska, M. E., Smith, M., Almarsson, Ö., Thompson, J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.035 · Cited by 642 · see citing works

The Human Cell Atlas: from vision to reality

Rozenblatt-Rosen, O., Stubbington, M. J. T., Regev, A., & Teichmann, S. A. (2017) · Nature · doi:10.1038/550451a · Cited by 638 · see citing works

Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors

Fukata, M., Chen, A., Vamadevan, A. S., Cohen, J., Breglio, K. J., Krishnareddy, S., Hsu, D. S., Xu, R., Harpaz, N., Dannenberg, A. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.008 · Cited by 623 · see citing works

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Yin, H., Song, C.-Q., Suresh, S., Wu, Q., Walsh, S., Rhym, L. H., Mintzer, E., Bolukbasi, M. F., Zhu, L. J., Kauffman, K., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.4005 · Cited by 499 · see citing works

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Dong, Y., Love, K. T., Dorkin, J. R., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R. L., Yin, H., Chen, Y., Vegas, A. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322937111 · Cited by 488 · see citing works

Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity

Husebye, H., Halaas, Ø., Stenmark, H., Tunheim, G., Sandanger, Ø., Bogen, B., Brech, A., Latz, E., & Espevik, T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600991 · Cited by 486 · see citing works

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Shirey, K. A., Lai, W., Scott, A. J., Lipsky, M., Mistry, P., Pletneva, L. M., Karp, C. L., McAlees, J. W., Gioannini, T. L., Weiss, J. P., et al. (2013) · Nature · doi:10.1038/nature12118 · Cited by 426 · see citing works

The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes

Wang, F., Yu, L., Monopoli, M. P., Sandin, P., Mahon, E., Salvati, A. L., & Dawson, K. A. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.04.010 · Cited by 426 · see citing works

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

Chen, D. L., Love, K. T., Chen, Y., Eltoukhy, A. A., Kastrup, C. J., Sahay, G., Jeon, A., Dong, Y., Whitehead, K. A., & Anderson, D. G. (2012) · Journal of the American Chemical Society · doi:10.1021/ja301621z · Cited by 422 · see citing works

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

Liang, F., Lindgren, G., Lin, A., Thompson, E. A., Ols, S., Röhss, J., John, S., Hassett, K., Yuzhakov, O., Bahl, K., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.006 · Cited by 395 · see citing works

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Soares, J., Pimentel‐Nunes, P., Roncon‐Albuquerque, R., & Leite-Moreira, A. F. (2010) · Hepatology International · doi:10.1007/s12072-010-9219-x · Cited by 369 · see citing works

Mapping protein binding sites on the biomolecular corona of nanoparticles

Kelly, P. M., Åberg, C., Polo, E., O'Connell, A., Cookman, J., Fallon, J., Krpetić, Ž., & Dawson, K. A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.47 · Cited by 360 · see citing works

The emerging role of Toll-like receptor 4 in myocardial inflammation

Yang, Y., Lv, J., Jiang, S., Ma, Z., Wang, D., Hu, W., Deng, C., Fan, C., Di, S., Sun, Y., et al. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.140 · Cited by 337 · see citing works

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

Schilte, C., Couderc, T., Chrétien, F. C., Sourisseau, M., Gangneux, N., Guivel‐Benhassine, F., Kraxner, A., Tschopp, J., Higgs, S., Michault, A., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090851 · Cited by 326 · see citing works

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

Sago, C. D., Lokugamage, M. P., Paunovska, K., Vanover, D. A., Monaco, C. M., Shah, N. N., Gamboa Castro, M., Anderson, S. E., Rudoltz, T. G., Lando, G. N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811276115 · Cited by 313 · see citing works

Localisation and trafficking of Toll-like receptors: an important mode of regulation

McGettrick, A. F., & O'Neill, L. A. J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.002 · Cited by 308 · see citing works

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Veiga, N., Goldsmith, M., Granot, Y., Rosenblum, D., Dammes, N., Kedmi, R., Ramishetti, S., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-06936-1 · Cited by 308 · see citing works

Effect of removing Kupffer cells on nanoparticle tumor delivery

Tavares, A. J., Poon, W., Zhang, Y.-N., Dai, Q., Besla, R., Ding, D., Ouyang, B., Li, A., Chen, J., Zheng, G., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713390114 · Cited by 287 · see citing works

Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll‐like receptor 4

Su, G. L., Klein, R., Aminlari, A., Zhang, H. Y., Steinstraesser, L., Alarcon, W. H., Remick, D., & Wang, S. C. (2000) · Hepatology · doi:10.1053/he.2000.5634 · Cited by 280 · see citing works

A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

Paunovska, K., Sago, C. D., Monaco, C. M., Hudson, W. H., Castro, M. G., Rudoltz, T. G., Kalathoor, S., Vanover, D. A., Santangelo, P. J., Ahmed, R., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00432 · Cited by 277 · see citing works

Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA

Patel, S., Ashwanikumar, N., Robinson, E., DuRoss, A., Sun, C., Murphy-Benenato, K. E., Mihai, C., Almarsson, Ö., & Sahay, G. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b02664 · Cited by 251 · see citing works

Exploiting Endocytosis for NanomedicinesPreprint

Akinc, A., & Battaglia, G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016980 · Cited by 211 · see citing works

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

Paunovska, K., Da Silva Sanchez, A. J., Sago, C. D., Gan, Z., Lokugamage, M. P., Islam, F. Z., Kalathoor, S., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201807748 · Cited by 205 · see citing works

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Kose, N., Fox, J. M., Sapparapu, G., Bombardi, R., Tennekoon, R. N., de Silva, A. D., Elbashir, S. M., Theisen, M. A., Humphris-Narayanan, E., Ciaramella, G., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw6647 · Cited by 202 · see citing works

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

Carlsson, L. G., Clarke, J. C., Yen, C. Y. T., Gregoire, F. M., Albery, T., Billger, M. A., Egnell, A., Gan, L., Jennbacken, K., Johansson, E., et al. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.04.003 · Cited by 180 · see citing works

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

Tan, Y., Zanoni, I., Cullen, T. W., Goodman, A. L., & Kagan, J. C. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.008 · Cited by 173 · see citing works

Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates

Zhu, X., Yin, L., Theisen, M., Zhuo, J., Siddiqui, S., Levy, B., Presnyak, V., Frassetto, A., Milton, J., Salerno, T., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.02.003 · Cited by 165 · see citing works

Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin

Creus, A. D., Abe, M., Lau, A. H., Hackstein, H., Raimondi, G., & Thomson, A. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2037 · Cited by 162 · see citing works

Analyzing 2000 <i>in Vivo</i> Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

Paunovska, K., Gil, C. J., Lokugamage, M. P., Sago, C. D., Sato, M., Lando, G. N., Gamboa Castro, M., Bryksin, A. V., & Dahlman, J. E. (2018) · ACS Nano · doi:10.1021/acsnano.8b03640 · Cited by 160 · see citing works

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands

Lokugamage, M. P., Sago, C. D., Gan, Z., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201902251 · Cited by 155 · see citing works

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Tiwari, P. M., Vanover, D. A., Lindsay, K. E., Bawage, S. S., Kirschman, J. L., Bhosle, S. M., Lifland, A. W., Zurla, C., & Santangelo, P. J. (2018) · Nature Communications · doi:10.1038/s41467-018-06508-3 · Cited by 139 · see citing works

Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution

Sago, C. D., Lokugamage, M. P., Islam, F. Z., Krupczak, B. R., Sato, M., & Dahlman, J. E. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08976 · Cited by 129 · see citing works

Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

Couch, Y., Трофимов, А. Н., Васильева, Н. А., Nikolenko, V. N., Steinbusch, H. W. M., Chekhonin, V. P., Schroeter, C. A., Lesch, K., Anthony, D. C., & Strekalova, T. V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0572-0 · Cited by 121 · see citing works

Zika virus disrupts molecular fingerprinting of human neurospheres

Garcez, P. P., Nascimento, J. M., de Vasconcelos, J. M., da Costa, R. M., Delvecchio, R., Trindade, P., Loiola, E. C., Higa, L. M., Cassoli, J. S., Vitória, G., et al. (2017) · Scientific Reports · doi:10.1038/srep40780 · Cited by 119 · see citing works

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

Kauffman, K. J., Oberli, M. A., Dorkin, J. R., Hurtado, J. E., Kaczmarek, J. C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A., & Anderson, D. G. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.11.005 · Cited by 103 · see citing works

Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High-Risk Melanoma

Sabado, R. L., Pavlick, A. C., Gnjatic, S., Cruz, C. M., Vengco, I., Hasan, F., Spadaccia, M. R., Darvishian, F., Chiriboga, L. A., Holman, R. M., et al. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0202 · Cited by 96 · see citing works

A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

Van Hoeven, N., Fox, C. B., Granger, B., Evers, T., Joshi, S. W., Nana, G. I., Evans, S. C., Lin, S., Liang, H., Liang, L., et al. (2017) · Scientific Reports · doi:10.1038/srep46426 · Cited by 87 · see citing works

Innate and Adaptive Immune Response in Fabry Disease

Mauhin, W., Lidove, O., Masat, E., Mingozzi, F., Mariampillai, K., Ziza, J.-M., & Benvéniste, O. (2015) · JIMD Reports · doi:10.1007/8904_2014_371 · Cited by 85 · see citing works

PKR Regulates TLR2/TLR4-Dependent Signaling in Murine Alveolar Macrophages

Cabanski, M., Steinmüller, M., Marsh, L. M., Surdziel, E., Seeger, W., & Lohmeyer, J. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0010oc · Cited by 81 · see citing works

Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

Kirschman, J. L., Bhosle, S. M., Vanover, D. A., Blanchard, E. L., Loomis, K. H., Zurla, C., Murray, K. A., Lam, B. C., & Santangelo, P. J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx290 · Cited by 77 · see citing works

Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression

Lee, Y., Kim, Y., Jung, Y. S., Kim, K.-S., Kim, D., Na, S., Lee, J.-M., Lee, C., & Choi, H. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.207 · Cited by 71 · see citing works

High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages

Das, A., Yang, C.-S., Arifuzzaman, S., Kim, S., Kim, S. Y., Jung, K., Lee, Y.-S., & Chai, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00022 · Cited by 67 · see citing works

Using Large Datasets to Understand Nanotechnology

Paunovska, K., Loughrey, D., Sago, C. D., Langer, R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201902798 · Cited by 67 · see citing works

Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles

Sago, C. D., Krupczak, B. R., Lokugamage, M. P., Gan, Z., & Dahlman, J. E. (2019) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-019-00573-4 · Cited by 53 · see citing works

Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo

Sago, C. D., Lokugamage, M. P., Lando, G. N., Djeddar, N., Shah, N. N., Syed, C., Bryksin, A. V., & Dahlman, J. E. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03149 · Cited by 45 · see citing works

Detecting and Number Counting of Single Engineered Nanoparticles by Digital Particle Polymerase Chain Reaction

Păunescu, D., Mora, C. A., Querci, L., Heckel, R., Puddu, M., Hattendorf, B., Günther, D., & Grass, R. N. (2015) · ACS Nano · doi:10.1021/acsnano.5b04429 · Cited by 30 · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

Drug delivery systems for RNA therapeutics

Paunovska, K., Loughrey, D., & Dahlman, J. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00439-4 · Cited by 1,349 · see citing works

Lipids and Lipid Derivatives for RNA Delivery

Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 638 · see citing works

Lipid nanoparticles for nucleic acid delivery: Current perspectives

Samaridou, E., Heyes, J. A., & Lutwyche, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.002 · Cited by 593 · see citing works

The landscape of mRNA nanomedicine

Huang, X., Kong, N., Zhang, X., Cao, Y., Langer, R., & Tao, W. (2022) · Nature Medicine · doi:10.1038/s41591-022-02061-1 · Cited by 511 · see citing works

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Lokugamage, M. P., Vanover, D. A., Beyersdorf, J. P., Hatit, M. Z. C., Rotolo, L., Echeverri, E. S., Peck, H. E., Ni, H., Yoon, J., Kim, Y., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00786-x · Cited by 507 · see citing works

mRNA vaccine: a potential therapeutic strategy

Wang, Y., Zhang, Z., Luo, J., Han, X., Wei, Y., & Wei, X. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01311-z · Cited by 422 · see citing works

The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs

LoPresti, S. T., Arral, M. L., Chaudhary, N., & Whitehead, K. A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.046 · Cited by 286 · see citing works

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

You, Y., Tian, Y., Yang, Z., Shi, J., Kwak, K. J., Tong, Y., Estania, A. P., Cao, J., Hsu, W.-H., Liu, Y., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00989-w · Cited by 258 · see citing works

Strategies to reduce the risks of mRNA drug and vaccine toxicity

Bitounis, D., Jacquinet, E., Rogers, M. A., & Amiji, M. M. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00859-3 · Cited by 237 · see citing works

Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Ni, H., Hatit, M. Z. C., Zhao, K., Loughrey, D., Lokugamage, M. P., Peck, H. E., Cid, A. D., Muralidharan, A., Kim, Y., Santangelo, P. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32281-5 · Cited by 192 · see citing works

Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing

Zhang, X., Zhao, W., Nguyen, G. N., Zhang, C., Zeng, C., Yan, J., Du, S., Hou, X., Li, W., Jiang, J., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc2315 · Cited by 183 · see citing works

Non-liver mRNA Delivery

Loughrey, D., & Dahlman, J. E. (2022) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00601 · Cited by 173 · see citing works

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

Szebeni, J., Storm, G., Ljubimova, J. Y., Castells, M., Phillips, E. J., Turjeman, K., Barenholz, Y., Crommelin, D. J. A., & Dobrovolskaia, M. A. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01071-x · Cited by 168 · see citing works

Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE)

Parhiz, H., Brenner, J. S., Patel, P., Papp, T. E., Shahnawaz, H., Li, Q., Shi, R., Zamora, M. E., Yadegari, A., Marcos-Contreras, O. A., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.027 · Cited by 151 · see citing works

Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles

Hatit, M. Z. C., Lokugamage, M. P., Dobrowolski, C. N., Paunovska, K., Ni, H., Zhao, K., Vanover, D. A., Beyersdorf, J. P., Peck, H. E., Loughrey, D., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-021-01030-y · Cited by 149 · see citing works

The use of RNA-based treatments in the field of cancer immunotherapy

Chehelgerdi, M., & Chehelgerdi, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01807-w · Cited by 146 · see citing works

Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination

Ben‐Akiva, E., Karlsson, J. E., Hemmati, S., Yu, H., Tzeng, S. Y., Pardoll, D. M., & Green, J. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2301606120 · Cited by 143 · see citing works

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Hu, M., Li, X., You, Z., Cai, R., & Chen, C. (2023) · Advanced Materials · doi:10.1002/adma.202303266 · Cited by 133 · see citing works

Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies

Wei, P.-S., Thota, N., John, G., Chang, E., Lee, S., Wang, Y., Ma, Z., Tsai, Y.-H., & Mei, K. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.030 · Cited by 130 · see citing works

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

Zhou, F., Huang, L., Li, S., Yang, W., Chen, F., Cai, Z., Liu, X., Xu, W., Lehto, V., Lächelt, U., et al. (2023) · Exploration · doi:10.1002/exp.20210146 · Cited by 115 · see citing works

Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach

Ly, H. H., Daniel, S., Soriano, S. K. V., Kis, Z., & Blakney, A. K. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00032 · Cited by 116 · see citing works

mRNA vaccines for COVID-19 and diverse diseases

Hussain, A., Yang, H., Zhang, M., Liu, Q., Alotaibi, G., Irfan, M. F., He, H., Chang, J. K., Liang, X., Weng, Y., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.032 · Cited by 117 · see citing works

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Wu, L., Li, X., Qian, X., Wang, S., Liu, J., & Yan, J. (2024) · Vaccines · doi:10.3390/vaccines12020186 · Cited by 125 · see citing works

In Vitro Engineering Chimeric Antigen Receptor Macrophages and T Cells by Lipid Nanoparticle-Mediated mRNA Delivery

Ye, Z., Chen, J., Zhao, X., Li, Y., Harmon, J., Huang, C., Chen, J., & Xu, Q. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01532 · Cited by 110 · see citing works

Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

Mukai, H., Ogawa, K., Kato, N., & Kawakami, S. (2022) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2022.100450 · Cited by 108 · see citing works

Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery

Dobrowolski, C. N., Paunovska, K., Echeverri, E. S., Loughrey, D., Sanchez, A. J. D. S., Ni, H., Hatit, M. Z. C., Lokugamage, M. P., Kuzminich, Y., Peck, H. E., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01146-9 · Cited by 103 · see citing works

mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

Bidram, M., Zhao, Y., Shebardina, N. G., Baldin, A. V., Bazhin, A. V., Ganjalikhany, M. R., Zamyatnin, A. A., & Ganjalıkhani-Hakemi, M. (2021) · Vaccines · doi:10.3390/vaccines9101060 · Cited by 106 · see citing works

mRNA Vaccines Against SARS‐CoV‐2 Variants Delivered by Lipid Nanoparticles Based on Novel Ionizable Lipids

Chen, K., Fan, N., Huang, H., Jiang, X., Qin, S., Xiao, W., Zheng, Q., Zhang, Y., Duan, X., Qin, Z., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204692 · Cited by 104 · see citing works

Lipid nanoparticle (LNP) mediated mRNA delivery in cardiovascular diseases: Advances in genome editing and CAR T cell therapy

Soroudi, S., Jaafari, M. R., & Arabi, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.023 · Cited by 91 · see citing works

An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates

Ripoll, M., Bernard, M., Vaure, C., Bazin, E., Commandeur, S., Perkov, V., Lemdani, K., Nicolaï, M., Bonifassi, P., Kichler, A., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121570 · Cited by 85 · see citing works

Nanoparticle-mediated delivery of anti-PU.1 siRNA via localized intracisternal administration reduces neuroinflammation

Ralvenius, W. T., Andresen, J. L., Huston, M. M., Penney, J., Bonner, J. M., Fenton, O. S., Langer, R., & Tsai, L. (2024) · Advanced Materials · doi:10.1002/adma.202309225 · Cited by 78 · see citing works

Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

Gan, Z., Lokugamage, M. P., Hatit, M. Z. C., Loughrey, D., Paunovska, K., Sato, M., Cristian, A., & Dahlman, J. E. (2020) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10161 · Cited by 75 · see citing works

Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization

Cao, Y., He, Z., Chen, Q., He, X., Su, L., Yu, W., Zhang, M., Yang, H., Huang, X., & Li, J. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01784 · Cited by 74 · see citing works

The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure

Paunovska, K., Sanchez, A. J. D. S., Lokugamage, M. P., Loughrey, D., Echeverri, E. S., Cristian, A., Hatit, M. Z. C., Santangelo, P. J., Zhao, K., & Dahlman, J. E. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03741 · Cited by 74 · see citing works

Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo

Walther, J., Porenta, D., Wilbie, D., Seinen, C. W., Benne, N., Yang, Q., de Jong, O. G., Lei, Z., & Mastrobattista, E. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114207 · Cited by 77 · see citing works

The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo

Radmand, A., Lokugamage, M. P., Kim, H., Dobrowolski, C. N., Zenhausern, R., Loughrey, D., Huayamares, S. G., Hatit, M. Z. C., Ni, H., Cid, A. D., et al. (2023) · Nano Letters · doi:10.1021/acs.nanolett.2c04479 · Cited by 71 · see citing works

Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery

Hatit, M. Z. C., Dobrowolski, C. N., Lokugamage, M. P., Loughrey, D., Ni, H., Zurla, C., Sanchez, A. J. D. S., Radmand, A., Huayamares, S. G., Zenhausern, R., et al. (2023) · Nature Chemistry · doi:10.1038/s41557-023-01138-9 · Cited by 71 · see citing works

Ionizable Lipid Nanoparticles for mRNA Delivery

Tang, X., Zhang, Y., & Han, X. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300006 · Cited by 71 · see citing works

Treating Cystic Fibrosis with mRNA and CRISPR

Sanchez, A. D. S., Paunovska, K., Cristian, A., & Dahlman, J. E. (2020) · Human Gene Therapy · doi:10.1089/hum.2020.137 · Cited by 72 · see citing works

Therapeutic RNA Delivery for COVID and Other Diseases

Dobrowolski, C. N., Paunovska, K., Hatit, M. Z. C., Lokugamage, M. P., & Dahlman, J. E. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002022 · Cited by 62 · see citing works

Delivery of mRNA for regulating functions of immune cells

Shi, J. Y., Huang, M., Lu, Z.-D., Du, X., Shen, S., Xu, C., & Wang, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.033 · Cited by 62 · see citing works

Pro‐Peptide‐Reinforced, Mucus‐Penetrating Pulmonary siRNA Delivery Mitigates Cytokine Storm in Pneumonia

Yang, J., Duan, S., Ye, H., Ge, C., Piao, C., Chen, Y., Lee, M., & Yin, L. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008960 · Cited by 61 · see citing works

Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis

Korzun, T., Moses, A. S., Jozić, A., Grigoriev, V., Newton, S., Kim, J., Diba, P., Sattler, A. L., Levasseur, P. R., Le, N., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c05088 · Cited by 58 · see citing works

Whither COVID-19 vaccines?

DeFrancesco, L. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0697-7 · Cited by 56 · see citing works

Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins

Tian, Y. P., Tirrell, M., & LaBelle, J. L. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102600 · Cited by 51 · see citing works

Targeting strategies for mRNA delivery

Meyer, R. A., Neshat, S. Y., Green, J. J., Santos, J. L., & Tuesca, A. D. (2022) · Materials Today Advances · doi:10.1016/j.mtadv.2022.100240 · Cited by 53 · see citing works

Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery

Sanchez, A. J. D. S., Zhao, K., Huayamares, S. G., Hatit, M. Z. C., Lokugamage, M. P., Loughrey, D., Dobrowolski, C. N., Wang, S., Kim, H., Paunovska, K., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.037 · Cited by 52 · see citing works

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Wang, Y., & Yu, C. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003545 · Cited by 52 · see citing works

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

de Vyver, T. V., Smedt, S. C. D., & Raemdonck, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114041 · Cited by 51 · see citing works

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Huang, P., Deng, H., Wang, C., Zhou, Y., & Chen, X. S. (2023) · Advanced Materials · doi:10.1002/adma.202307822 · Cited by 49 · see citing works

Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines

Kubara, K., Yamazaki, K., Miyazaki, T., Kondo, K., Kurotaki, D., Tamura, T., & Suzuki, Y. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.020 · Cited by 50 · see citing works

Advanced Nanomaterials for Preparedness Against (Re‐)Emerging Viral Diseases

Kim, E., Lim, E., Park, G., Park, C., Lim, J., Lee, H. J., Na, W., Yeom, M., Kim, J., Song, D., et al. (2021) · Advanced Materials · doi:10.1002/adma.202005927 · Cited by 47 · see citing works

On the mechanism of tissue-selective gene delivery by lipid nanoparticles

Kimura, S., & Harashima, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.052 · Cited by 46 · see citing works

Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as a Carrier

Huang, X., Zheng, R., Ding, F., Yang, J., Xie, M., Liu, X., Li, J., Feng, J. C., Zhu, X., & Zhang, C. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00375 · Cited by 44 · see citing works

Dendritic Cell‐Mimicking Nanoparticles Promote mRNA Delivery to Lymphoid Organs

Cao, Y., Long, J., Sun, H., Miao, Y., Sang, Y., Lü, H., Yu, C., Zhang, Z., Wang, L., Yang, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202302423 · Cited by 42 · see citing works

Ushering in the era of tRNA medicines

Anastassiadis, T., & Köhrer, C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105246 · Cited by 37 · see citing works

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

Qin, Z., Bouteau, A., Herbst, C., & Igyártó, B. Z. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010830 · Cited by 38 · see citing works

From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics

Korzun, T., Moses, A. S., Diba, P., Sattler, A. L., Taratula, O. R., Sahay, G., Taratula, O., & Marks, D. L. (2023) · Pharmaceuticals · doi:10.3390/ph16081088 · Cited by 37 · see citing works

Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles for Efficient Tumor-Specific Multiplex Gene Editing

Liang, Y., Zhang, J., Xu, C., Wang, J., Han, W., Yang, J., Wu, S., An, J., Liu, J., Zhang, Z., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04116 · Cited by 36 · see citing works

A Polymeric Nanoparticle Formulation for Targeted mRNA Delivery to Fibroblasts

Rodrigues, A. F., Rebelo, C., Simões, S. M. N., Paulo, C., Pinho, S. L. C., Francisco, V., & Ferreira, L. (2022) · Advanced Science · doi:10.1002/advs.202205475 · Cited by 33 · see citing works

In Vivo Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Editor mRNA

Chen, Z., Kelly, K., Cheng, H., Dong, X., Hedger, A. K., Li, L., Sontheimer, E. J., & Watts, J. K. (2023) · GEN Biotechnology · doi:10.1089/genbio.2023.0045 · Cited by 37 · see citing works

Nanoparticle-based immunotherapeutics: From the properties of nanocores to the differential effects of administration routes

Perez‐Potti, A., Rodríguez-Pérez, M., Polo, E., Pelaz, B., & del Pino, P. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114829 · Cited by 34 · see citing works

Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

Meany, E. L., Klich, J. H., Jons, C. K., Mao, T., Chaudhary, N., Utz, A., Baillet, J., Song, Y. E., Saouaf, O. M., Ou, B. S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr2631 · Cited by 35 · see citing works

Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy

Li, Y., Liu, L., Ji, W., Peng, H., Zhao, R., & Zhang, X. (2020) · Nano Today · doi:10.1016/j.nantod.2020.101006 · Cited by 33 · see citing works

RNA Nanomedicine: Delivery Strategies and Applications

Byun, J., Wu, Y., Park, J.-W., Kim, J. S., Li, Q., Choi, J., Shin, N., Lan, M., Cai, Y., Lee, J., et al. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00860-z · Cited by 30 · see citing works

Dynamically covalent lipid nanoparticles mediate CRISPR-Cas9 genome editing against choroidal neovascularization in mice

Cao, D., Zhu, J., Guo, Y., Zhou, Y., Zeng, J., Tu, Y., Zhao, Z., Xie, L., Song, E., Zhu, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adj0006 · Cited by 29 · see citing works

Nucleic acid delivery and nanoparticle design for COVID vaccines

Andresen, J. L., & Fenton, O. S. (2021) · MRS Bulletin · doi:10.1557/s43577-021-00169-2 · Cited by 29 · see citing works

Poly (beta‐amino ester) as an in vivo nanocarrier for therapeutic nucleic acids

Nezhad, M. S. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28269 · Cited by 28 · see citing works

Harnessing Topology and Stereochemistry of Glycidylamine‐Derived Lipid Nanoparticles for in Vivo mRNA Delivery to Immune Cells in Spleen and Their Application for Cancer Vaccination

Elwakil, M. M. A., Suzuki, R., Khalifa, A. M., Elshami, R. M., Isono, T., Elewa, Y. H. A., Sato, Y., Nakamura, T., Satoh, T., & Harashima, H. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202303795 · Cited by 28 · see citing works

Increased PIP3 activity blocks nanoparticle mRNA delivery

Paunovska, K., Sanchez, A. D. S., Foster, M. T., Loughrey, D., Blanchard, E. L., Islam, F. Z., Gan, Z., Mantalaris, A., Santangelo, P. J., & Dahlman, J. E. (2020) · Science Advances · doi:10.1126/sciadv.aba5672 · Cited by 26 · see citing works

Helper Lipid-Enhanced mRNA Delivery for Treating Metabolic Dysfunction-Associated Fatty Liver Disease

Guo, Z., Zeng, C., Shen, Y., Hu, L., Zhang, H., Li, Z., Dong, W. X., Wang, Q., Liu, Q., Wang, Y., et al. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c01458 · Cited by 26 · see citing works

mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity

Kenney, L. L., Chiu, R. S.-Y., Dutra, M. N., Wactor, A., Honan, C., Shelerud, L. M., Corrigan, J. J., Yu, K. J., Ferrari, J. D., Jeffrey, K. L., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101717 · Cited by 27 · see citing works

Lipid nanoparticles technology in vaccines: Shaping the future of prophylactic medicine

Abdellatif, A. A. H., Younis, M. A., Alsowinea, A. F., Abdallah, E. M., Abdel‐Bakky, M. S., Al-Subaiyel, A., Hassan, Y. A., & Tawfeek, H. M. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113111 · Cited by 24 · see citing works

Robust anti-tumor immunity through the integration of targeted lipid nanoparticle-based mRNA nanovaccines with PD-1/PD-L1 blockade

Jin, C., Zhang, Y., Li, B., Gao, T., Wang, B., & Hua, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101136 · Cited by 19 · see citing works

Nonclinical Safety Assessment of Lipid Nanoparticle-and Emulsion-Based Self-Amplifying mRNA Vaccines in Rats

Donahue, D. A., Ballesteros, C., Maruggi, G., Glover, C., Ringenberg, M. A., Marquis, M., Abdeljelil, N. B., Ashraf, A., Rodriguez, L.-A., & Stokes, A. H. (2022) · International Journal of Toxicology · doi:10.1177/10915818221138781 · Cited by 17 · see citing works

Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations

Costa, B., Boueri, B., Oliveira, C. L., Silveira, I., & Ribeiro, A. J. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2075846 · Cited by 16 · see citing works

Regulatory circular RNAs in viral diseases: applications in diagnosis and therapy

Wang, W. J., Sun, L., Huang, M.-T., Quan, Y., Jiang, T., Miao, Z., & Zhang, Q. (2023) · RNA Biology · doi:10.1080/15476286.2023.2272118 · Cited by 15 · see citing works

Golden Threads of Lipid Nanoparticles (LNPs) contributing to COVID-19 mRNA Vaccine: A Review

Vasu, M., Yadav, P., Satyanarayana, Y., Ahlawat, J., Dulla, S., & Kumar, K. N. (2024) · BioNanoScience · doi:10.1007/s12668-024-01589-5 · Cited by 15 · see citing works

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashionPreprint

Qin, Z., Bouteau, A., Herbst, C., & Igyártó, B. Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.16.484616 · Cited by 15 · see citing works

Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review

Belay, W. Y., Nibret, G., & Aschale, Y. (2023) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s418314 · Cited by 16 · see citing works

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Zhang, M., Chen, S., Hu, H.-J., Ong, Y., & Ni, Q. (2025) · Advanced Materials · doi:10.1002/adma.202509880 · Cited by 16 · see citing works

Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

Eş, İ., Thakur, A., Khaneghah, A. M., Foged, C., & de la Torre, L. G. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2024.108342 · Cited by 13 · see citing works

COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

du Preez, H. N., Lin, J., Maguire, G. E. M., Aldous, C. M., & Kruger, H. G. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14296 · Cited by 12 · see citing works

Dual-Targeting mRNA Cancer Vaccines for Simultaneous Antigen Presentation in Dendritic and Tumor Cells

Kim, Y., Park, W., Kim, S., Kim, E. H., Choi, J., Jang, H., Ryu, Y., Hwang, J., Kim, M., Cho, Y. J., et al. (2026) · ACS Nano · doi:10.1021/acsnano.5c20535 · Cited by 9 · see citing works

The promise of RNA-based therapeutics in revolutionizing heart failure management – a narrative review of current evidence

Aderinto, N., Muili, A. O., Olatunji, G. D., Edun, M. T., & Aboderin, G. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001118 · Cited by 9 · see citing works

Current Perspectives and Future Prospects of mRNA Vaccines against Viral Diseases: A Brief Review.

Vasavi, K., Poloju, D., Puvvala, B., Madineni, K., Balaji, S. N., Sheela, C. M. P., Manchikanti, S. S. C., & Moon, S. M. (2022) · PubMed Central · doi:10.22088/ijmcm.bums.11.3.260 · Cited by 8 · see citing works

mRNA—From COVID-19 Treatment to Cancer Immunotherapy

Kŕause, W. (2023) · Biomedicines · doi:10.3390/biomedicines11020308 · Cited by 8 · see citing works

Nano–Bio Interactions: Exploring the Biological Behavior and the Fate of Lipid-Based Gene Delivery Systems

Kimura, S., & Harashima, H. (2024) · BioDrugs · doi:10.1007/s40259-024-00647-4 · Cited by 7 · see citing works

Therapeutic extracellular vesicle production is substantially increased by inhibition of cellular cholesterol biosynthesis

Martin, S., McConnell, R. E., Harrison, R. A., Jang, S. C., Sia, C. L., Kamerkar, S., Duboff, A. G., Jacob, L. M., Finn, J. D., & Estes, S. D. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28401 · Cited by 6 · see citing works

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Han, Y., Wang, Y., Gao, X., Lei, Y., Li, Y., & Tang, Z. (2026) · Cancer Nexus · doi:10.1002/cnx2.70021 · Cited by 6 · see citing works

Recent strategies for enhanced delivery of mRNA to the lungs

Heiser, B. J., Veyssi, A., & Ghosh, D. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2485669 · Cited by 6 · see citing works

The rise of mRNA therapeutic vaccines

Du, J., Fan, Z., Huang, J., Li, Z., Hu, H., & Li, Y. (2025) · RSC Pharmaceutics · doi:10.1039/d4pm00309h · Cited by 5 · see citing works

Design of messenger RNA vaccines based on lipid-polymer hybrid nanoparticles

Baghel, S. S., Lokras, A. G., Dias, B. A., Landry, M. R., Cérda, S. L., Wadhwa, A., Herrera‐Barrera, M., Thakur, A., Rades, T., Franzyk, H., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114385 · Cited by 7 · see citing works

Tumor agnostic drug delivery with dynamic nanohydrogels

Housley, S. N., Bourque, A. R., Matyunina, L. V., Panicker, I., Echeverri, E. S., Izykowicz, M. M., Herrmann, O. A., Lee, S., Arboleda, J. C., Jamali, V., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-66788-4 · Cited by 5 · see citing works

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Hu, R., Dou, Y., Li, C., Mu, Y., Ouyang, H., Shen, W., & Zhang, J. (2026) · Advanced Science · doi:10.1002/advs.75548 · Cited by 5 · see citing works

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Lokras, A. G., Baghel, S. S., Jensen, R. F., Thakur, A., Franzyk, H., Thofte, O., Herrera‐Barrera, M., Landry, M. R., Ongun, M., Tami, A., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202505627 · Cited by 4 · see citing works

Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme

Wang, Y., & Yu, C. (2020) · Angewandte Chemie · doi:10.1002/ange.202003545 · Cited by 4 · see citing works

Engineered protein circuits for cancer therapyPreprint

Lu, A. C., Moeller, L., Moore, S., Ho, K., Tobin, V., Qiang, A., Zhang, E., Li, Z., Wang, M., Xia, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.16.647665 · Cited by 4 · see citing works

Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity

Walters, A. A., Hanafy, B. I., Lu, C., Marelli, S., Zam, A., Liu, K., Foreman, R. E., Soundararajan, R., Collin, P., Lindfors, L., et al. (2026) · Small · doi:10.1002/smll.74283 · Cited by 3 · see citing works

Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA

Bates, S. M. (2024) · Apollo (University of Cambridge) · doi:10.17863/cam.112923

Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis

Korzun, T., Moses, A. S., Jozić, A., Grigoriev, V., Newton, S., Kim, J., Diba, P., Sattler, A. L., Levasseur, P. R., Le, N., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c05088 · Cited by 58 · see citing works

Entry Without Expression: Internalisation Does Not Predict mRNA Translation for Targeted Lipid Nanoparticles

Smyth, C. H., Mollé, L. M., McLeod, V., Chen, M. Z., & Johnston, A. P. R. (2026) · Small Science · doi:10.1002/smsc.70313 · Cited by 1 · see citing works

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Pardi, N., Tuyishime, S., Muramatsu, H., Kariko, K., Mui, B. L., Tam, Y. K., Madden, T. D., Hope, M. J., & Weissman, D. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.007 · Cited by 1,014 · see citing works

Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4

Zelkoski, A. E., Lu, Z., Sukumar, G., Dalgard, C. L., Said, H., Alameh, M., Mitre, E. E. S., & Malloy, A. M. W. (2025) · npj Vaccines · doi:10.1038/s41541-025-01124-x · Cited by 113 · see citing works