The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
Open accessAbstract
Significance: N6-methyladnosine (m6A) represents one of the most common RNA modifications. Biochemical analyses have identified ALKBH5 as an eraser of m6A. The present study represents the first molecular characterization of the Alkbh5 knockout mouse model. Our data associate m6A erasure with mRNA length control. Specifically, proper m6A demethylation is required for correct splicing and selective degradation of longer 3′-UTR transcripts, which are abundant in mitotic and meiotic male germ cells, but these longer 3′-UTR transcripts become rapidly degraded in the haploid male germ cells. Aberrant m6A levels in spermatogenic cells are incompatible with normal spermatogenesis and male fertility.
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Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
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Cited by
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
The Critical Role of RNA m6A Methylation in Cancer
Lan, Q., Liu, P. Y., Haase, J., Bell, J. L., Hüttelmaier, S., & Liu, T. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2965 · Cited by 720
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
Zhou, K. I., Shi, H., Lyu, R., Wylder, A. C., Matuszek, Ż., Pan, J. N., He, C., Parisien, M., & Pan, T. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.005 · Cited by 382
Role of m6A RNA methylation in cardiovascular disease (Review)
Qin, Y., Li, L., Luo, E., Hou, J., Yan, G., Wang, D., Qiao, Y., & Tang, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4746 · Cited by 328
Self-citationThe Biogenesis and Precise Control of RNA m6A Methylation
Huang, H., Weng, H., & Chen, J. (2020) · Trends in Genetics · doi:10.1016/j.tig.2019.10.011 · Cited by 304
Metadata
- Authors
- Tang, C., Klukovich, R., Peng, H., Wang, Z., Yu, T., Zhang, Y., Zheng, H., Klungland, A., & Yan, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-12-26
- Volume
- 115
- Issue
- 2
- Pages
- E325-E333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2776310795
- Cited by
- 539
- References
- 3
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Tang, C., Klukovich, R., Peng, H., Wang, Z., Yu, T., Zhang, Y., Zheng, H., Klungland, A., & Yan, W. (2018). ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1717794115
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