The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
Open accessAbstract
Summary N6-methyladenosine (m6A) modification occurs co-transcriptionally and impacts pre-mRNA processing, however the mechanism of co-transcriptional m6A-dependent alternative splicing regulation is still poorly understood. HnRNPG is an m6A reader protein that binds RNA through RRM and Arg-Gly-Gly (RGG) motifs. Here, we show that hnRNPG directly binds to the phosphorylated carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) using RGG motifs in its low-complexity region. Through interactions with the phosphorylated CTD and nascent RNA, hnRNPG associates co-transcriptionally with RNAPII and regulates alternative splicing transcriptome-wide. m6A near splice sites in nascent premRNA modulate hnRNPG binding, which influences RNAPII occupancy patterns and promotes exon inclusion. Our results reveal an integrated mechanism of co-transcriptional m6A-mediated splicing regulation, in which an m6A reader protein uses RGG motifs to co-transcriptionally interact with both RNAPII and m6A-modified nascent pre-mRNA to modulate RNAPII occupancy and alternative splicing.
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Metadata
- Authors
- Zhou, K. I., Shi, H., Lyu, R., Wylder, A. C., Matuszek, Ż., Pan, J. N., He, C., Parisien, M., & Pan, T.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 76
- Issue
- 1
- Pages
- 70-81.e9
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2969469813
- Cited by
- 382
- References
- 81
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhou, K. I., Shi, H., Lyu, R., Wylder, A. C., Matuszek, Ż., Pan, J. N., He, C., Parisien, M., & Pan, T. (2019). Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.07.005
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