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Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
Open accessAbstract
Significance: Stress cannot be avoided in the present competitive world, and chronic stress is associated with detrimental effects on physical health, including the progression of inflammatory bowel disease (IBD). However, the mechanisms behind it are less clearly understood. This study showed that chronic stress disturbed gut microbiota, thereby triggering immune system response and facilitating dextran sulfate sodium-induced colitis. Results also showed stress-deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. This study adds to our understanding of interactions between microbiota and host and provides the basis for future clinical studies of microbiota manipulation and transplantation and the development of new therapeutic strategies for depression or IBD.
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“Moreover, animals that are exposed to chronic stress are predisposed to the development of inflammatory conditions, such as experimental autoimmune encephalitis, colitis, atherosclerosis and diabetes31–34.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [32]
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In the citing paper
“More specifically, a study of mice with induced colitis found that chronic stress was associated with a significant increase in inflammation-enhancing bacteria (15).”
From The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease (2023) · cites this paper as [15]
In the citing paper
“In general, stress disturbs the gut microbiota, triggers immune system dysfunction and facilitates DSS-induced colitis (47).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [47]
In the citing paper
“In contrast, when the intestinal microbiota was shared by cohousing or was destroyed by antibiotics, the severity of DSS-induced colitis was indistinguishable between the stressed and control groups, unequivocally suggesting that the gut microbiota is responsible for the deleterious effects of stress.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [47]
In the citing paper
“A recent study based on a dextran sulfate sodium (DSS)-induced colitis model provided evidence that chronic stress increases sensitivity to colitis via dysbiosis and immune system dysfunction.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [47]
In the citing paper
“Moreover, a recent study revealed that chronic stress damages the gut microbiota and increases susceptibility to DSS-induced colitis in mice.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [47]
In the citing paper
“The downregulated expression of mucin-2 and lysozyme caused by stress is implicated in the disturbance of the microbiota (47).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [47]
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Metadata
- Authors
- Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., Li, X., Wang, Y., Bian, J.-S., Sun, D., Kong, L., Birnbaumer, L., & Yang, Y.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing University of Chinese Medicine (CN)
- National University of Singapore (SG)
- State Key Laboratory of Natural Medicines, China Pharmaceutical University, 211198 Nanjing, China;
- Pontificia Universidad Católica Argentina (AR)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-03-12
- Volume
- 115
- Issue
- 13
- Pages
- E2960-E2969
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5879702
- OpenAlex
- W2791456383
- Cited by
- 400
- References
- 61
- Citations by year
- 2026: 25 · 2025: 49 · 2024: 50 · 2023: 55 · 2022: 70 · 2021: 68 · 2020: 44 · 2019: 30 · 2018: 9
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-04-30)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- Funders
- Intramural research program of the NIH (Z01-ES101684)
- National Science foundation of china grants (81673468, 91529304, 81473230, 81273547, 91129731, 81603132, 81403020, 81502407, 81673559)
- natural science foundation of jiangsu province grants (BK20160753, BK20140666)
- China Postdoctoral Science Foundation (2016M591965)
- the 111 project (B18056)
- State key laboratory of natural medicines innovation research and incubation foundation (SKLNMZZCX201609)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- chronic stress, colitis, gut microbiota, DSS-induced colitis, MUC2, lysozyme, cohousing, microbiota transfer, antibiotic therapy, intestinal inflammation, immune response
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colitis, Disease Models, Animal, Immunity, Innate, Inflammation, Male, Mice, Inbred C57BL, Muramidase, Stress, Physiological, Interleukin-6, Dextran Sulfate, Mice, Knockout, STAT3 Transcription Factor, Mice, Mucin-2
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