Cited by 402Gut microbiota and healthInflammatory Bowel DiseaseGastrointestinal motility and disorders

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Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

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Gao, Xinghua, Cao, Qiuhua, Cheng, Yan, Zhao, Dandan, Wang, Zhuo, Yang, Hongbao, Wu, Qijin, You, Linjun, Wang, Yue, Lin, Yanting, Li, Xianjing, Wang, Yun, Bian, Jin-Song, Sun, Dongdong, Kong, Lingyi, Birnbaumer, Lutz, Yang, Yong·2018·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1720696115PMC PMC5879702

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Abstract

Significance: Stress cannot be avoided in the present competitive world, and chronic stress is associated with detrimental effects on physical health, including the progression of inflammatory bowel disease (IBD). However, the mechanisms behind it are less clearly understood. This study showed that chronic stress disturbed gut microbiota, thereby triggering immune system response and facilitating dextran sulfate sodium-induced colitis. Results also showed stress-deficient expression of mucin-2 and lysozyme, which may contribute to the disorder of gut microbiota. This study adds to our understanding of interactions between microbiota and host and provides the basis for future clinical studies of microbiota manipulation and transplantation and the development of new therapeutic strategies for depression or IBD.

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Authors: Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., Li, X., Wang, Y., Bian, J.-S., Sun, D., Kong, L., Birnbaumer, L., & Yang, Y.
Affiliations: China Pharmaceutical University (CN)
Nanjing University of Chinese Medicine (CN)
National University of Singapore (SG)
State Key Laboratory of Natural Medicines, China Pharmaceutical University, 211198 Nanjing, China;
Pontificia Universidad Católica Argentina (AR)
ORCID: Gao, Xinghua
Cao, Qiuhua
Cheng, Yan
Zhao, Dandan
Wang, Zhuo
Yang, Hongbao
You, Linjun
Wang, Yue
Lin, Yanting
Li, Xianjing
Wang, Yun
Bian, Jin-Song
Sun, Dongdong
Birnbaumer, Lutz
Yang, Yong
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2018-03-12
Volume: 115
Issue: 13
Pages: E2960-E2969
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1720696115
PMC: PMC5879702
OpenAlex: W2791456383
Cited by: 400
References: 61
Citations by year: 2026: 25 · 2025: 49 · 2024: 50 · 2023: 55 · 2022: 70 · 2021: 68 · 2020: 44 · 2019: 30 · 2018: 9
FWCI: 13.42
Type: journal article
Language: en
Update notices: correction (2018-04-30)
Open access: bronze
doi.org
Licence: www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 184 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
Funders: Intramural research program of the NIH (Z01-ES101684)
National Science foundation of china grants (81673468, 91529304, 81473230, 81273547, 91129731, 81603132, 81403020, 81502407, 81673559)
natural science foundation of jiangsu province grants (BK20160753, BK20140666)
China Postdoctoral Science Foundation (2016M591965)
the 111 project (B18056)
State key laboratory of natural medicines innovation research and incubation foundation (SKLNMZZCX201609)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: chronic stress, colitis, gut microbiota, DSS-induced colitis, MUC2, lysozyme, cohousing, microbiota transfer, antibiotic therapy, intestinal inflammation, immune response
MeSH terms: Gastrointestinal Microbiome, Animals, Colitis, Disease Models, Animal, Immunity, Innate, Inflammation, Male, Mice, Inbred C57BL, Muramidase, Stress, Physiological, Interleukin-6, Dextran Sulfate, Mice, Knockout, STAT3 Transcription Factor, Mice, Mucin-2

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Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

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