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Molecular imaging with endogenous substances
Open accessAbstract
Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as 13 C and 15 N in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond 13 C MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM 13 C-labeled urea, ready for injection. The in vivo T 1 relaxation time of 13 C in the urea solution was determined to 20 ± 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (≈1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [ 13 C]urea solution in a rat. The results show that it is possible to perform 13 C angiography with a signal-to-noise ratio of ≈275 in ≈0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.
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Cited by
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Hyperpolarized 13 C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
Merritt, M. E., Harrison, C., Storey, C., Jeffrey, F. M., Sherry, A. D., & Malloy, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706235104 · Cited by 278
Metadata
- Authors
- Golman, K., Ardenkjær-Larsen, J. H., Petersson, J. S., Månsson, S., & Leunbach, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-08-20
- Volume
- 100
- Issue
- 18
- Pages
- 10435-10439
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002190301
- Cited by
- 427
- References
- 0
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Golman, K., Ardenkjær-Larsen, J. H., Petersson, J. S., Månsson, S., & Leunbach, I. (2003). Molecular imaging with endogenous substances. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1733836100
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