The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility
Open accessAbstract
Significance: Coronaviruses exhibit a propensity for interspecies transmission, with SARS- and MERS-coronaviruses as notable examples. Cross-species transmission by coronaviruses is foremost determined by the virus’ ability to bind receptors of new hosts. We here report that the recently identified, yet globally distributed porcine deltacoronavirus employs host aminopeptidase N (APN) as an entry receptor via S protein-mediated interaction with an interspecies conserved domain that allows for APN orthologue-mediated entry. Identification of APN as a deltacoronavirus receptor emphasizes the remarkable preferential employment of cell surface host peptidases as receptors by coronaviruses. Our findings provide important insight into how receptor usage of coronaviruses may fuel cross-host transmission between distantly related species and necessitate surveillance studies of deltacoronaviruses in thus far unappreciated potential reservoirs, including humans.
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923
Self-citationSARS and MERS: recent insights into emerging coronaviruses
de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.81 · Cited by 3,510
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Raj, V. S., Mou, H., Smits, S. L., Dekkers, D. H. W., Müller, M. A., Dijkman, R., Muth, D., Demmers, J. A. A., Zaki, A., Fouchier, R. A. M., et al. (2013) · Nature · doi:10.1038/nature12005 · Cited by 2,061
Self-citationPre-fusion structure of a human coronavirus spike protein
Kirchdoerfer, R. N., Cottrell, C. A., Wang, N., Pallesen, J., Yassine, H. M., Turner, H. L., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2016) · Nature · doi:10.1038/nature17200 · Cited by 765
Geoghegan, J. L., Duchêne, S., & Holmes, E. C. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006215 · Cited by 275
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Live and Wet Markets: Food Access versus the Risk of Disease Emergence
Naguib, M. M., Li, R., Ling, J., Grace, D., Nguyen-Viet, H., & Lindahl, J. F. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.02.007 · Cited by 106
Du, W., Debski-Antoniak, O., Drabek, D., van Haperen, R., van Dortmondt, M., van der Lee, J., Drulyte, I., van Kuppeveld, F. J. M., Grosveld, F., Hurdiss, D. L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49693-0 · Cited by 19
Self-citationUHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
(2025) · doi:10.1038/s41467-025-64977-9 · Cited by 1
Metadata
- Authors
- Li, W., Hulswit, R. J. G., Kenney, S. P., Widjaja, I., Jung, K., Alhamo, M. A., van Dieren, B., van Kuppeveld, F. J. M., Saif, L. J., & Bosch, B.-J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-05-14
- Volume
- 115
- Issue
- 22
- Pages
- E5135-E5143
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2799725394
- Cited by
- 301
- References
- 5
- FWCI
- 25.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, W., Hulswit, R. J. G., Kenney, S. P., Widjaja, I., Jung, K., Alhamo, M. A., van Dieren, B., van Kuppeveld, F. J. M., Saif, L. J., & Bosch, B.-J. (2018). Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1802879115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
