The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa
Open accessAbstract
Significance: Bacteria live in aggregates at sites of chronic infection, and aggregated growth is thought to be important in producing key infection phenotypes such as antibiotic tolerance. We found that entropic forces generated by polymers abundant at chronic infection sites can cause bacteria to aggregate by a mechanism known as “depletion aggregation.” This aggregation mechanism does not require biofilm formation functions, but it does cause bacteria to become much less susceptible to killing by antibiotics. These findings indicate that aggregation could be a default growth mode at infection sites. It might be useful to target mechanisms of depletion-mediated antibiotic tolerance for the treatment of chronic infections.
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“Biofilm formation in vitro can also be impacted by non-biological processes such as depletion aggregation98–100.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [100]
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“Although the importance of this aggregation mechanism in vivo is unknown, biofilm aggregation through this process can enhance antibiotic tolerance and is impacted by the chemical composition of the outer surface of P. aeruginosa98–100.”
From Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility (2025) · cites this paper as [100]
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Cites
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa
Schaber, J. A., Carty, N. L., McDonald, N. A., Graham, E. D., Cheluvappa, R., Griswold, J. A., & Hamood, A. N. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45617-0 · Cited by 224
Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates
Cassat, J. E., Dunman, P. M., McAleese, F., Murphy, E., Projan, S. J., & Smeltzer, M. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.576-592.2005 · Cited by 112
Cited by
Antimicrobial Resistance in ESKAPE Pathogens
De Oliveira, D. M. P., Forde, B. M., Kidd, T. J., Harris, P. N. A., Schembri, M. A., Beatson, S. A., Paterson, D. L., & Walker, M. J. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00181-19 · Cited by 2,078
Pseudomonas aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility
Letizia, M., Diggle, S. P., & Whiteley, M. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01193-8 · Cited by 231
Candida auris Phenotypic Heterogeneity Determines Pathogenicity In Vitro
Brown, J. L., Delaney, C., Short, B., Butcher, M. C., McKloud, E., Williams, C., Kean, R., & Ramage, G. (2020) · mSphere · doi:10.1128/msphere.00371-20 · Cited by 76
Why have aggregative multicellular organisms stayed simple?
Márquez-Zacarías, P., Conlin, P. L., Tong, K., Pentz, J. T., & Ratcliff, W. C. (2021) · Current Genetics · doi:10.1007/s00294-021-01193-0 · Cited by 43
Bagheri, M., Nikolenko, H., Arasteh, S., Rezaei, N., Behzadi, M., Dathe, M., & Hancock, R. E. W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c04336 · Cited by 31
Metadata
- Authors
- Secor, P. R., Michaels, L. A., Ratjen, A., Jennings, L. K., & Singh, P. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-10
- Volume
- 115
- Issue
- 42
- Pages
- 10780-10785
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2893127586
- Cited by
- 171
- References
- 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Secor, P. R., Michaels, L. A., Ratjen, A., Jennings, L. K., & Singh, P. K. (2018). Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1806005115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
