Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa

Schaber, J. Andy; Carty, Nancy L.; McDonald, Naomi A.; Graham, Eric D.; Cheluvappa, Rajkumar; Griswold, John A.; Hamood, Abdul N.

doi:10.1099/jmm.0.45617-0

Cited by 224Bacterial biofilms and quorum sensingEscherichia coli research studiesVibrio bacteria research studies

Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa

Schaber, J. Andy, Carty, Nancy L., McDonald, Naomi A., Graham, Eric D., Cheluvappa, Rajkumar, Griswold, John A., Hamood, Abdul N.·2004·Journal of Medical Microbiology

DOI 10.1099/jmm.0.45617-0

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Abstract

Pseudomonas aeruginosa produces multiple virulence factors and causes different types of infections. Previous clinical studies identified P. aeruginosa isolates that lack individual virulence factors. However, the impact of losing several virulence factors simultaneously on the in vivo virulence of P. aeruginosa is not completely understood. The P. aeruginosa cell-to-cell communication system, or quorum sensing (QS), controls the production of several virulence factors. Animal studies using constructed QS mutants indicated that loss of the QS system severely impacts the virulence of P. aeruginosa. In this study, we tried to determine if deficiency within the QS system compromises the ability of P. aeruginosa to establish infections in humans. We have identified five QS-deficient strains through screening 200 isolates from patients with urinary tract, lower respiratory tract and wound infections. These strains lacked LasB and LasA activities and produced either no or very low levels of the autoinducers N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone. PCR analysis revealed that three isolates contained all four QS genes (lasI, lasR, rhlI and rhlR) while two isolates lacked both the lasR and rhlR genes. We also examined the five isolates for other virulence factors. The isolates produced variable levels of exotoxin A and, with one exception, were deficient in pyocyanin production. One isolate produced the type III secretion system (TTSS) effector proteins ExoS and ExoT, two isolates produced ExoT only and two isolates produced no TTSS proteins. The isolates produced weak to moderate biofilms on abiotic surfaces. Analysis of the patients' data revealed that two of the isolates represented a single strain that was isolated twice from the same patient within a 1 month interval. One QS-deficient clinical isolate (CI-1) lacked all tested virulence factors and produced a weak biofilm. These results suggest that naturally occurring QS-deficient strains of P. aeruginosa do occur and are capable of causing infections; and, that besides the known virulence factors, additional factors may contribute to the ability of certain strains such as CI-1 to establish an infection.

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Spontaneous QS- and virulence-deficient P. aeruginosa mutants are still capable of causing wound infections.
“Our study has also shown the lack of Pseudomonas virulence factors and genes for QS molecules within wound isolates, which goes in line with previous studies [64] confirming that spontaneous QS- and virulence-deficient P. aeruginosa mutants are still capable of causing wound infections.”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [64]

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Journal of Medical Microbiology (2004), 53, 841–853 DOI 10.1099/jmm.0.45617-0 45617 & 2004 SGM Printed in Great Britain 841 Correspondence
Hamood, A. N., Griswold, J. A., & Hamood, A. N. (2004)
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Authors: Schaber, J. A., Carty, N. L., McDonald, N. A., Graham, E. D., Cheluvappa, R., Griswold, J. A., & Hamood, A. N.
Affiliations: Texas Tech University (US)
ORCID: Cheluvappa, Rajkumar
Griswold, John A.
Hamood, Abdul N.
Venue: Journal of Medical Microbiology
Publisher: Microbiology Society
Published: 2004-09-01
Volume: 53
Issue: 9
Pages: 841-853
ISSN: 0022-2615 (ISSN-L)
1473-5644
DOI: 10.1099/jmm.0.45617-0
OpenAlex: W2163902276
Cited by: 224
References: 66
Citations by year: 2026: 6 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 16 · 2012: 18
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Locations: Journal of Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Texas Tech University
Directorate for Biological Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Vibrio bacteria research studies
Keywords: Pseudomonas aeruginosa, quorum sensing, virulence factors, clinical isolates, lasB, LASA, autoinducers, LasR, RhlR, type III secretion system, exoS, ExoT, pyocyanin, exotoxin A, biofilm formation, urinary tract infection, lower respiratory tract infection, wound infection
MeSH terms: Bacterial Proteins, Humans, Metalloendopeptidases, Mutation, Pseudomonas aeruginosa, Pseudomonas Infections, Transcription, Genetic, Virulence, 4-Butyrolactone, Gene Expression Regulation, Bacterial, Biofilms

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Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa

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