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Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.
Open accessAbstract
A hybrid circuit of a semiconductor chip and synaptically connected neurons was implemented and characterized. Individual nerve cells from the snail Lymnaea stagnalis were immobilized on a silicon chip by microscopic picket fences of polyimide. The cells formed a network with electrical synapses after outgrowth in brain conditioned medium. Pairs of neurons were electronically interfaced for noninvasive stimulation and recording. Voltage pulses were applied to a capacitive stimulator on the chip to excite the attached neuron. Signals were transmitted in the neuronal net and elicited an action potential in a second neuron. The postsynaptic excitation modulated the current of a transistor on the chip. The implementation of the silicon-neuron-neuron-silicon circuit constitutes a proof-of-principle experiment for the development of neuroelectronic systems to be used in studies on neuronal signal processing, neurocomputation, and neuroprosthetics.
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“An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites (Freitas, 1999b; Zeck and Fromherz, 2001; Patolsky et al., 2006).”
From Human Brain/Cloud Interface (2019) · cites this paper as Zeck and Fromherz, 2001
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Metadata
- Authors
- Zeck, G., & Fromherz, P.
- Affiliations
- Max Planck Institute of Biochemistry (DE)
- Corresponding author
- Fromherz, Peter
- ORCID
- Zeck, Günther
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-08-28
- Volume
- 98
- Issue
- 18
- Pages
- 10457-10462
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC56982
- OpenAlex
- W2125305661
- Cited by
- 290
- References
- 34
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- electrical synapses, neuronal networks, action potential propagation, neuroprosthetics, neural computation
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Electrophysiology, Lymnaea, Microscopy, Electron, Scanning, Neurobiology, Neurons, Semiconductors, Synapses, Signal Transduction, Cells, Immobilized, In Vitro Techniques
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