The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Chaperone-mediated autophagy is involved in the execution of ferroptosis
Open accessAbstract
Significance: This study reveals a common regulatory mechanism mediated by HSP90 that is shared by necroptosis and ferroptosis, two necrotic cell death mechanisms that have previously had no known mechanistic connections. Furthermore, this study demonstrates the involvement of chaperone-mediated autophagy in the execution of ferroptosis. Given the role of HSP90 as an important chaperone involved in major human maladies ranging from neurodegenerations to cancers, our work further implicates the roles of necroptosis and ferroptosis in human diseases.
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Cites
Regulation of Ferroptotic Cancer Cell Death by GPX4
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Identification of RIP1 kinase as a specific cellular target of necrostatins
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Self-citationRIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
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Cited by
Ferroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationFerroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
The Cell Biology of Ferroptosis
Dixon, S. J., & Olzmann, J. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00703-5 · Cited by 1,596
GPX4 at the crossroads of lipid homeostasis and ferroptosis
Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,025
Metadata
- Authors
- Wu, Z., Geng, Y., Lu, X., Shi, Y., Wu, G., Zhang, M., Shan, B., Pan, H., & Yuan, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-02-04
- Volume
- 116
- Issue
- 8
- Pages
- 2996-3005
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2912822929
- Cited by
- 577
- References
- 19
- FWCI
- 37.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, Z., Geng, Y., Lu, X., Shi, Y., Wu, G., Zhang, M., Shan, B., Pan, H., & Yuan, J. (2019). Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1819728116
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