RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation

Zhang, Sitao; Su, Yaning; Ying, Zhengxin; Guo, Dejia; Pan, Chenjie; Guo, Jia; Zou, Ziye; Wang, Lei; Zhang, Ze; Jiang, Zhaodi; Zhang, Zhiyuan; Wang, Xiaodong

doi:10.1073/pnas.1819917116

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation

Demyelination in the central nervous system (CNS) underlies many human diseases, including multiple sclerosis (MS). We report here the findings of our study of the CNS demyelination process using immune-induced [experimental autoimmune encephalomyelitis (EAE)] and chemical-induced [cuprizone (CPZ…