The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
Open accessAbstract
Significance: RAS genes are among the most mutated proto-oncogenes in human cancer. The mechanisms supporting RAS transformation are not fully understood, particularly regarding the relative contributions of oxidant versus antioxidant pathways. Here, we report that the cystine/glutamate transporter xCT is essential for RAS-induced tumorigenicity by enhancing antioxidant glutathione synthesis. Our findings uncover that RAS controls xCT transcription by downstream activation of ETS-1 to synergize with ATF4. This has clinical relevance since xCT expression is upregulated in human cancers exhibiting an activated RAS pathway. Therefore, oncogenic RAS transformation is supported by induction of an antioxidant program, highlighting xCT as a potential vulnerability for therapeutic targeting.
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Cited by
Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654
Targeting Ferroptosis as a Vulnerability in Cancer
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The metabolic landscape of RAS-driven cancers from biology to therapy
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Metadata
- Authors
- Lim, J. K. M., Delaidelli, A., Minaker, S. W., Zhang, H.-F., Colovic, M., Yang, H., Negri, G. L., von Karstedt, S., Lockwood, W. W., Schaffer, P., Leprivier, G., & Sorensen, P. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-04-18
- Volume
- 116
- Issue
- 19
- Pages
- 9433-9442
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2940348880
- Cited by
- 308
- References
- 59
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. https://app.cochat.ai/papers/10.1073/pnas.1821323116
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- Lim, J. K. M., Delaidelli, A., Minaker, S. W., Zhang, H.-F., Colovic, M., Yang, H., Negri, G. L., von Karstedt, S., Lockwood, W. W., Schaffer, P., Leprivier, G., & Sorensen, P. H. (2019). Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1821323116
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