The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion
Open accessAbstract
CD1d-restricted natural killer T (NKT) cells are a subset of regulatory T cells that react with glycolipid antigens. Although preclinical studies have effectively targeted NKT cells for immunotherapy, little is known regarding the early in vivo response of these cells to antigenic stimulation. We have analyzed the early response of NKT cells to glycolipid antigens and bacterial infection by using specific reagents for tracking these cells. Our results demonstrate dramatic in vivo expansion and surface phenotype alterations after NKT cell activation with α-galactosylceramide. In addition, we show significant NK1.1 down-modulation on NKT cells in the setting of oral Salmonella infection. Our results indicate that in vivo activation of NKT cells leads to a dynamic response characterized by surface receptor down-modulation and expansion. These findings alter current understanding of NKT cell biology and should aid in the rational design of NKT cell-based immunotherapies.
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Cites
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., & Kronenberg, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.741 · Cited by 887
Self-citationCarnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4647 · Cited by 854
The unconventional lifestyle of NKT cells
Kronenberg, M., & Gapin, L. (2002) · Nature Reviews Immunology · doi:10.1038/nri854 · Cited by 747
The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response
Taniguchi, M., Harada, M., Kojo, S., Nakayama, T., & Wakao, H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141057 · Cited by 669
Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice
Morita, M., Motoki, K., Akimoto, K., Natori, T., Sakai, T., Sawa, E., Yamaji, K., Koezuka, Y., Kobayashi, E., & Fukushima, H. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00012a018 · Cited by 599
QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR
Overbergh, L., Valckx, D., Waer, M., & Mathieu, C. (1999) · Cytokine · doi:10.1006/cyto.1998.0426 · Cited by 557
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
Benlagha, K., Weiss, A., Beavis, A., Teyton, L., & Bendelac, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.11.1895 · Cited by 556
Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs
Fujii, S.-I., Shimizu, K., Kronenberg, M., & Steinman, R. M. (2002) · Nature Immunology · doi:10.1038/ni827 · Cited by 544
Critical contribution of liver natural killer T cells to a murine model of hepatitis
Takeda, K., Hayakawa, Y., Van Kaer, L., Matsuda, H., Yagita, H., & Okumura, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040566697 · Cited by 539
Self-citation
Cited by
Glycolipid antigen induces long-term natural killer T cell anergy in mice
Parekh, V. V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24762 · Cited by 458
T cell fate and clonality inference from single-cell transcriptomes
(2016) · doi:10.1038/nmeth.3800 · Cited by 434
Ishikawa, A., Motohashi, S., Ishikawa, E., Fuchida, H., Higashino, K., Otsuji, M., Iizasa, T., Nakayama, T., Taniguchi, M., & Fujisawa, T. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1453 · Cited by 403
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
Gao, B., Radaeva, S., & Park, O. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309135 · Cited by 377
Harnessing invariant NKT cells in vaccination strategies
Cerundolo, V., Silk, J. D., Masri, S. H., & Salio, M. (2009) · Nature Reviews Immunology · doi:10.1038/nri2451 · Cited by 358
Metadata
- Authors
- Wilson, M. T., Johansson, C., Olivares-Villagómez, D., Singh, A. K., Stanic, A. K., Wang, C.-R., Joyce, S., Wick, M. J., & Van Kaer, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-05
- Volume
- 100
- Issue
- 19
- Pages
- 10913-10918
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969789349
- Cited by
- 338
- References
- 35
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wilson, M. T., Johansson, C., Olivares-Villagómez, D., Singh, A. K., Stanic, A. K., Wang, C.-R., Joyce, S., Wick, M. J., & Van Kaer, L. (2003). The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1833166100
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