The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Glycolipid antigen induces long-term natural killer T cell anergy in mice
Open accessAbstract
Natural killer T (NKT) cells recognize glycolipid antigens presented by the MHC class I-related glycoprotein CD1d. The in vivo dynamics of the NKT cell population in response to glycolipid activation remain poorly understood. Here, we show that a single administration of the synthetic glycolipid alpha-galactosylceramide (alpha-GalCer) induces long-term NKT cell unresponsiveness in mice. NKT cells failed to proliferate and produce IFN-gamma upon alpha-GalCer restimulation but retained the capacity to produce IL-4. Consequently, we found that activation of anergic NKT cells with alpha-GalCer exacerbated, rather than prevented, B16 metastasis formation, but that these cells retained their capacity to protect mice against experimental autoimmune encephalomyelitis. NKT cell anergy was induced in a thymus-independent manner and maintained in an NKT cell-autonomous manner. The anergic state could be broken by IL-2 and by stimuli that bypass proximal TCR signaling events. Collectively, the kinetics of initial NKT cell activation, expansion, and induction of anergy in response to alpha-GalCer administration resemble the responses of conventional T cells to strong stimuli such as superantigens. Our findings have important implications for the development of NKT cell-based vaccines and immunotherapies.
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CD4+CD25+ suppressor T cells: more questions than answers
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Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
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Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
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CD1: Antigen Presentation and T Cell Function
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Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
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Going both ways: Immune regulation via CD1d-dependent NKT cells
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Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
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Gao, B., Radaeva, S., & Park, O. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309135 · Cited by 377
Harnessing invariant NKT cells in vaccination strategies
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Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Ruf, B., Heinrich, B., & Greten, T. F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00572-w · Cited by 312
Biology of CD1- and MR1-Restricted T Cells
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Metadata
- Authors
- Parekh, V. V.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-08-25
- Volume
- 115
- Issue
- 9
- Pages
- 2572-2583
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2090777237
- Cited by
- 458
- References
- 50
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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