The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues
Open accessAbstract
Most recent evidence suggests that the process of tissue repair is driven by stem-like cells that reside in multiple tissues but are replenished by precursor cells from bone marrow. Among the candidates for the reparative cells are the adult stem cells from bone marrow referred to as either mesenchymal stem cells or marrow stromal cells (MSCs). We recently found that after MSCs were replated at very low densities to generate single-cell-derived colonies, they did not exit a prolonged lag period until they synthesized and secreted considerable quantities of Dickkopf-1, an inhibitor of the canonical Wnt signaling pathway. We also found that when the cells were cocultured with heat-shocked pulmonary epithelial cells, they differentiated into epithelial cells. Most of the MSCs differentiated without evidence of cell fusion but up to one-quarter underwent cell fusion with the epithelial cells. A few also underwent nuclear fusion. The results are consistent with the interesting possibility that MSCs and similar cells repair tissue injury by three different mechanisms: creation of a milieu that enhances regeneration of endogenous cells, transdifferentiation, and perhaps cell fusion.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Changing potency by spontaneous fusion
Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G. (2002) · Nature · doi:10.1038/nature729 · Cited by 1,494
Liver from bone marrow in humans
Theise, N. D., Nimmakayalu, M., Gardner, R., Illei, P. B., Morgan, G., Teperman, L., Henegariu, O., & Krause, D. S. (2000) · Hepatology · doi:10.1053/jhep.2000.9124 · Cited by 1,210
Cited by
Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wirkner, U., Krause, U., Blake, J., Schwager, C., Eckstein, V., Ansorge, W., et al. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.07.003 · Cited by 1,259
Yoshimura, H., Muneta, T., Nimura, A., Yokoyama, A., Koga, H., & Sekiya, I. (2007) · Cell and Tissue Research · doi:10.1007/s00441-006-0308-z · Cited by 734
Lee, R. H., Seo, M. J., Reger, R. L., Spees, J. L., Pulin, A. A., Olson, S. D., & Prockop, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608249103 · Cited by 710
Self-citationTögel, F., Weiss, K., Yang, Y., Hu, Z., Zhang, P., & Westenfelder, C. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00339.2006 · Cited by 641
HEO, J. S., CHOI, Y., KIM, H.-S., & KIM, H. O. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2413 · Cited by 495
Metadata
- Authors
- Prockop, D. J., Gregory, C. A., & Spees, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-30
- Volume
- 100
- Issue
- suppl_1
- Pages
- 11917-11923
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105159857
- Cited by
- 416
- References
- 4
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
