The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Targeting RIPK1 for the treatment of human diseases
Open accessAbstract
Significance: RIPK1 plays a critical role in mediating deleterious responses downstream of TNFR1. RIPK1 inhibitors have been progressed successfully past human phase I clinical studies. This paper discusses why RIPK1 inhibitors present an opportunity for developing oral drugs for a range of human degenerative and inflammatory diseases, especially CNS pathologies, including ALS, Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, stroke, and lysosomal storage diseases.
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Cites
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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Self-citationMixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
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Cited by
Wang, Y., & Kanneganti, T.-D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.038 · Cited by 545
Kinase inhibition in autoimmunity and inflammation
Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431
Necroptosis: a crucial pathogenic mediator of human disease
Choi, M. E., Price, D. R., Ryter, S. W., & Choi, A. M. K. (2019) · JCI Insight · doi:10.1172/jci.insight.128834 · Cited by 419
Modes of Regulated Cell Death in Cancer
Koren, E., & Fuchs, Y. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0789 · Cited by 371
Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials
Miao, J., Ma, H., Yang, Y., Liao, Y., Lin, C., Zheng, J., Yu, M., & Lan, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1201982 · Cited by 293
Metadata
- Authors
- Degterev, A., Ofengeim, D., & Yuan, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-05-02
- Volume
- 116
- Issue
- 20
- Pages
- 9714-9722
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2942761172
- Cited by
- 408
- References
- 124
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Funders
- HHS | NIH | National Institute on Aging (1R01AG047231)
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- Degterev, A., Ofengeim, D., & Yuan, J. (2019). Targeting RIPK1 for the treatment of human diseases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1901179116
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
