Kinase inhibition in autoimmunity and inflammation
Open accessAbstract
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet medical needs in some areas still exist. One of the main therapeutic approaches to alleviate dysregulated inflammation has been to target the activity of kinases that regulate production of inflammatory mediators. Small-molecule kinase inhibitors have the potential for broad efficacy, convenience and tissue penetrance, and thus often offer important advantages over biologics. However, designing kinase inhibitors with target selectivity and minimal off-target effects can be challenging. Nevertheless, immense progress has been made in advancing kinase inhibitors with desirable drug-like properties into the clinic, including inhibitors of JAKs, IRAK4, RIPKs, BTK, SYK and TPL2. This Review will address the latest discoveries around kinase inhibitors with an emphasis on clinically validated autoimmunity and inflammatory pathways.
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IRAK4's scaffolding role in Toll-like receptor signalling around the myddosome is established.
“Particularly for IRAK4, its scaffolding role in Toll-like receptor (TLR) signalling around the myddosome is established165,172”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [165]
The role of IRAK4 in inflammatory conditions, as well as in B cell lymphomas, is well established, and several inhibitors are currently in clinical trials in autoimmune indications.
“but the role of IRAK4 in inflammatory conditions, as well as in B cell lymphomas, is well established, and several inhibitors are currently in clinical trials in autoimmune indications165,171.”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [165]
BTK is a well-established target in inflammation, as well as in oncology, with approved drugs in the clinic.
“BTK is a well-established target in inflammation, as well as in oncology, with approved drugs in the clinic164,165”
From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [165]
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PROTAC targeted protein degraders: the past is prologue
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- Authors
- Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D.
- Affiliations
- Trex (United States) (US)
- Genentech (US)
- Synthekine (US)
- Corresponding author
- Zarrin, Ali A.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2020-10-19
- Volume
- 20
- Issue
- 1
- Pages
- 39-63
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC7569567
- OpenAlex
- W3093133909
- Cited by
- 431
- References
- 269
- Citations by year
- 2026: 47 · 2025: 80 · 2024: 96 · 2023: 72 · 2022: 85 · 2021: 50 · 2020: 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- kinase inhibitors, autoimmunity, inflammation, small-molecule kinase inhibitors, JAK inhibitors, IRAK4, BTK inhibitors, SYK inhibitors, inflammatory mediators, off-target effects, target selectivity, unmet medical needs
- MeSH terms
- Animals, Autoimmune Diseases, Humans, Inflammation, Protein Kinases, Autoimmunity, Protein Kinase Inhibitors
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