The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Low ambient humidity impairs barrier function and innate resistance against influenza infection
Open accessAbstract
In the temperate regions, seasonal influenza virus outbreaks correlate closely with decreases in humidity. While low ambient humidity is known to enhance viral transmission, its impact on host response to influenza virus infection and disease outcome remains unclear. Here, we showed that housing Mx1 congenic mice in low relative humidity makes mice more susceptible to severe disease following respiratory challenge with influenza A virus. We find that inhalation of dry air impairs mucociliary clearance, innate antiviral defense, and tissue repair. Moreover, disease exacerbated by low relative humidity was ameliorated in caspase-1/11–deficient Mx1 mice, independent of viral burden. Single-cell RNA sequencing revealed that induction of IFN-stimulated genes in response to viral infection was diminished in multiple cell types in the lung of mice housed in low humidity condition. These results indicate that exposure to dry air impairs host defense against influenza infection, reduces tissue repair, and inflicts caspase-dependent disease pathology.
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Cites
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature
Lowen, A. C., Mubareka, S., Steel, J., & Palese, P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030151 · Cited by 1,669
Brass, A. L., Huang, I.-C., Benita, Y., John, S. P., Krishnan, M. N., Feeley, E. M., Ryan, B. J., Weyer, J. L., van der Weyden, L., Fikrig, E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.12.017 · Cited by 1,269
The Pathology of Influenza Virus Infections
Taubenberger, J. K., & Morens, D. M. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154316 · Cited by 1,111
Innate immunity to influenza virus infection
Iwasaki, A., & Pillai, P. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3665 · Cited by 1,068
Self-citationEpidemic influenza and vitamin D
CANNELL, J. J., VIETH, R., UMHAU, J. C., HOLICK, M. F., GRANT, W. B., MADRONICH, S., GARLAND, C. F., & GIOVANNUCCI, E. (2006) · Epidemiology and Infection · doi:10.1017/s0950268806007175 · Cited by 1,034
Cilia and Mucociliary Clearance
Bustamante-Marin, X. M., & Ostrowski, L. E. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028241 · Cited by 830
Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway
Fraga, J., Maranha, A., Mendes, V., Pereira, P. J. B., Empadinhas, N., & Macedo-Ribeiro, S. (2015) · Scientific Reports · doi:10.1038/srep08026 · Cited by 819
IFITM3 restricts the morbidity and mortality associated with influenza
The GenISIS Investigators, Everitt, A. R., The MOSAIC Investigators, Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., et al. (2012) · Nature · doi:10.1038/nature10921 · Cited by 782
Tumour necrosis factors α and β inhibit virus replication and synergize with interferons
Wong, G. H. W., & Goeddel, D. V. (1986) · Nature · doi:10.1038/323819a0 · Cited by 713
Cited by
Cheemarla, N. R., Watkins, T. A., Mihaylova, V. T., Wang, B., Zhao, D., Wang, G., Landry, M. L., & Foxman, E. F. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210583 · Cited by 213
Spaceflight virology: what do we know about viral threats in the spaceflight environment?
Pavletić, B., Runzheimer, K., Siems, K., Koch, S., Cortesão, M., Ramos-Nascimento, A., & Moeller, R. (2022) · Astrobiology · doi:10.1089/ast.2021.0009 · Cited by 30
Jaric, I., Voelkl, B., Clerc, M., Schmid, M. W., Novak, J., Rosso, M., Rufener, R., von Kortzfleisch, V. T., Richter, S. H., Buettner, M., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001837 · Cited by 32
Metadata
- Authors
- Kudo, E., Song, E., Yockey, L. J., Rakib, T., Wong, P. W., Homer, R. J., & Iwasaki, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2019-05-13
- Volume
- 116
- Issue
- 22
- Pages
- 10905-10910
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2944868902
- Cited by
- 341
- References
- 42
- FWCI
- 32.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kudo, E., Song, E., Yockey, L. J., Rakib, T., Wong, P. W., Homer, R. J., & Iwasaki, A. (2019). Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1902840116
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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