The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Innate immunity to influenza virus infection
Open accessAbstract
Influenza viruses are a major pathogen of both humans and animals. Recent studies using gene-knockout mice have led to an in-depth understanding of the innate sensors that detect influenza virus infection in a variety of cell types. Signalling downstream of these sensors induces distinct sets of effector mechanisms that block virus replication and promote viral clearance by inducing innate and adaptive immune responses. In this Review, we discuss the various ways in which the innate immune system uses pattern recognition receptors to detect and respond to influenza virus infection. We consider whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and propose rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection.
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Cites
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Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Low ambient humidity impairs barrier function and innate resistance against influenza infection
Kudo, E., Song, E., Yockey, L. J., Rakib, T., Wong, P. W., Homer, R. J., & Iwasaki, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902840116 · Cited by 341
Self-citation
Metadata
- Authors
- Iwasaki, A., & Pillai, P. S.
- Venue
- Nature Reviews Immunology
- Published
- 2014-04-25
- Volume
- 14
- Issue
- 5
- Pages
- 315-328
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2071688420
- Cited by
- 1,068
- References
- 23
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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