The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Investigating stem cells in human colon by using methylation patterns
Open accessAbstract
The stem cells that maintain human colon crypts are poorly characterized. To better determine stem cell numbers and how they divide, epigenetic patterns were used as cell fate markers. Methylation exhibits somatic inheritance and random changes that potentially record lifelong stem cell division histories as binary strings or tags in adjacent CpG sites. Methylation tag contents of individual crypts were sampled with bisulfite sequencing at three presumably neutral loci. Methylation increased with aging but varied between crypts and was mosaic within single crypts. Some crypts appeared to be quasi-clonal as they contained more unique tags than expected if crypts were maintained by single immortal stem cells. The complex epigenetic patterns were more consistent with a crypt niche model wherein multiple stem cells were present and replaced through periodic symmetric divisions. Methylation tags provide evidence that normal human crypts are long-lived, accumulate random methylation errors, and contain multiple stem cells that go through “bottlenecks” during life.
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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Sottoriva, A., Spiteri, I., Piccirillo, S. G. M., Touloumis, A., Collins, V. P., Marioni, J. C., Curtis, C., Watts, C., & Tavaré, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219747110 · Cited by 1,737
Self-citationSingle-cell sequencing-based technologies will revolutionize whole-organism science
Shapiro, E., Biezuner, T., & Linnarsson, S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3542 · Cited by 1,177
Huang, E. H., Hynes, M. J., Zhang, T., Ginestier, C., Dontu, G., Appelman, H., Fields, J. Z., Wicha, M. S., & Boman, B. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4418 · Cited by 1,045
A Big Bang model of human colorectal tumor growth
Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M. P., Zhao, J., Marjoram, P., Siegmund, K., Press, M. F., Shibata, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3214 · Cited by 1,015
Self-citationCancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
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Metadata
- Authors
- Yatabe, Y., Tavaré, S., & Shibata, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-08-21
- Volume
- 98
- Issue
- 19
- Pages
- 10839-10844
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965766641
- Cited by
- 368
- References
- 31
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
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