Cited by 344Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Regulation of adipose tissue inflammation by interleukin 6

Open access

Han, Myoung Sook, White, Alexis, Perry, Rachel J., Camporez, Joao-Paulo, Hidalgo, Juan, Shulman, Gerald I., Davis, Roger J.·2020·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1920004117PMC PMC7022151

Open this paper in CoChat — free account Open PDF

Abstract

Significance Chronic low-grade inflammation is a key driver of metabolic syndrome. This inflammatory response is mediated by immune-cell infiltration and the expression of inflammatory cytokines. IL6 is implicated in this response, but the physiological role of IL6 signaling is unclear. Here, we demonstrate that the source of IL6 influences the nature of the inflammatory response. We report that IL6 secreted by myeloid cells inhibits adipose tissue macrophage (ATM) accumulation by a canonical signaling mechanism, but IL6 secreted by adipocytes or muscle promotes ATM accumulation by a noncanonical mechanism. These observations provide physiological insight into the complexity of IL6-mediated regulation of inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1920004117

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898
IL-6 pathway in the liver: From physiopathology to therapy
Schmidt-Arras, D., & Rose-John, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.004 · Cited by 881 · cited 1×
“The physiology of IL6 signaling is complex because the effects of IL6 on metabolism requires signal integration between cell types (4) that involve proinflammatory, anti-inflammatory, and noninflammatory mechanisms (5).”
Background
Interleukin-6 in acute exercise and training: what is the biological relevance?
Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.012 · Cited by 719

Flagged first, then by citations

Show all 37 references

Sorted by citations

Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“The finding of opposite actions of IL-6, depending of the cell source, appeared to be due to a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle) which involved increased expression of the ADAM10/17 metalloprotease that enhances transsignaling v…”
Background
Inflammation and Skeletal Muscle Wasting During Cachexia
Webster, J. M., Kempen, L. J. A. P., Hardy, R. S., & Langen, R. C. J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.597675 · Cited by 372
The complex role of adipokines in obesity, inflammation, and autoimmunity
Taylor, E. B. (2021) · Clinical Science · doi:10.1042/cs20200895 · Cited by 369
Interleukin 6 as an Energy Allocator in Muscle Tissue
Kistner, T. M., Pedersen, B. K., & Lieberman, D. E. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00538-4 · Cited by 295
Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
Lee, K., Wu, P.-S., & Lin, H. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0237 · Cited by 269
Sarcopenic obesity: Emerging mechanisms and therapeutic potential
Axelrod, C. L., Dantas, W. S., & Kirwan, J. P. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155639 · Cited by 204
Adipose Tissue and Metabolic Health
An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 170
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156
Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling
Huang, T., Song, J. G., Gao, J. L., Cheng, J. R., Xie, H., Zhang, L., Wang, Y., Gao, Z., Wang, X., Wang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31126-5 · Cited by 155
The exercise IL-6 enigma in cancer
Orange, S. T., Leslie, J., Ross, M., Mann, D. A., & Wackerhage, H. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.08.001 · Cited by 158
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 143
Interplay of skeletal muscle and adipose tissue: sarcopenic obesity.
Park, M., & Choi, K. M. (2023) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2023.155577 · Cited by 106
The potential of probiotics in the amelioration of hyperuricemia
Zhao, H., Lu, Z., & Lu, Y. (2022) · Food & Function · doi:10.1039/d1fo03206b · Cited by 128
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium
Si, J., Kang, H., You, H. J., & Ko, G. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2078619 · Cited by 130
The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit
Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 126
Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression
Huang, Q., Wu, M., Wu, X., Zhang, Y., & Xia, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188761 · Cited by 124
Cancer cachexia: multilevel metabolic dysfunction
Díaz, M. B., Rohm, M., & Herzig, S. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01167-9 · Cited by 113
Suppressing adipocyte inflammation promotes insulin resistance in mice
Zhu, Q., An, Y., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M., & Scherer, P. E. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101010 · Cited by 104
Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease
Chaurasia, B., Talbot, C. L., & Summers, S. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576347 · Cited by 99
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis
Yan, S., Kumari, M., Xiao, H., Jacobs, C. L., Kochumon, S., Jedrychowski, M. P., Chouchani, E. T., Ahmad, R., & Rosen, E. D. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144888 · Cited by 92
COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality
Maurya, R., Sebastian, P., Namdeo, M., Devender, M., & Gertler, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649359 · Cited by 100
Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)
Yang, F. T., & Stanford, K. I. (2022) · Current Obesity Reports · doi:10.1007/s13679-021-00465-7 · Cited by 100
The NLRP3 inflammasome regulates adipose tissue metabolism
Barra, N. G., Henriksbo, B. D., Anhê, F. F., & Schertzer, J. D. (2020) · Biochemical Journal · doi:10.1042/bcj20190472 · Cited by 93
Increased COVID-19 infections in women with polycystic ovary syndrome: a population-based study
Subramanian, A., Anand, A., Adderley, N. J., Okoth, K., Toulis, K. A., Gokhale, K. M., Sainsbury, C. A. R., O’Reilly, M., Arlt, W., & Nirantharakumar, K. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1163 · Cited by 92
The role of stress kinases in metabolic disease
Nikolić, I., Leiva, M., & Sabio, G. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00418-5 · Cited by 92
The controversial role of IL-6 in adipose tissue on obesity-induced dysregulation of glucose metabolism
Wueest, S., & Konrad, D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00306.2020 · Cited by 91
Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases
Jouy, S. H., Mohan, S., Scichilone, G., Mostafa, A., & Mahmoud, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12092129 · Cited by 96
Reappraisal of Adipose Tissue Inflammation in Obesity
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_10 · Cited by 86
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun, K., Li, X., & Scherer, P. E. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220020 · Cited by 162
Lipid-Induced Mechanisms of Metabolic Syndrome
Denisenko, Y., Kytikovа, O. Y., Novgorodtseva, T. P., Antonyuk, M. V., Gvozdenko, T. A., & Анатольевна, К. Т. (2020) · Journal of Obesity · doi:10.1155/2020/5762395 · Cited by 81
Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models
Feraco, A., Gorini, S., Armani, A., Camajani, E., Rizzo, M., & Caprio, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179327 · Cited by 78
Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages
McKernan, K. E., Varghese, M., Patel, R. R., & Singer, K. (2020) · Adipocyte · doi:10.1080/21623945.2020.1760674 · Cited by 70
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, L., Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, N. J. W., Klein, S., Ortiz, C., Uschner, F. E., et al. (2022) · Molecular Systems Biology · doi:10.15252/msb.202210947 · Cited by 67
Anti-Inflammatory Diets in Fertility: An Evidence Review
Alesi, S., Villani, A. M., Mantzioris, E., Takele, W. W., Cowan, S., Moran, L., & Mousa, A. (2022) · Nutrients · doi:10.3390/nu14193914 · Cited by 76
Vascularized adipocyte organoid model using isolated human microvessel fragments
Strobel, H. A., Gerton, T. J., & Hoying, J. B. (2021) · Biofabrication · doi:10.1088/1758-5090/abe187 · Cited by 70
Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism
Lin, W., Song, H., Shen, J., Wang, J., Yang, Y., Yang, Y., Cao, J., Xue, L., Zhao, F., Xiao, T., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1110926 · Cited by 74
Exerkines and cardiometabolic benefits of exercise: from bench to clinic
Jin, L., Díaz-Cañestro, C., Wang, Y., Tse, M. A., & Xu, A. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00027-z · Cited by 76
Adipokines from white adipose tissue in regulation of whole body energy homeostasis
Sahu, B., & Bal, N. C. (2022) · Biochimie · doi:10.1016/j.biochi.2022.09.003 · Cited by 73
Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions
Guardia, L. D., & Codella, R. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.09.003 · Cited by 68
Interleukin‐6 initiates muscle‐ and adipose tissue wasting in a novel C57BL/6 model of cancer‐associated cachexia
Pototschnig, I., Feiler, U., Diwoky, C., Vesely, P. W., Rauchenwald, T., Paar, M., Bakiri, L., Pajed, L., Hofer, P., Kashofer, K., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13109 · Cited by 61
Futile lipid cycling: from biochemistry to physiology
Sharma, A. K., Khandelwal, R., & Wolfrum, C. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01003-0 · Cited by 66
The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast
Almerie, M. Q., & Kerrigan, D. D. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109883 · Cited by 60
Aging adipose tissue, insulin resistance, and type 2 diabetes
Zhao, Y., & Yue, R. (2023) · Biogerontology · doi:10.1007/s10522-023-10067-6 · Cited by 57
JNK signaling pathway in metabolic disorders: An emerging therapeutic target
Garg, R., Kumariya, S., Katekar, R. A., Verma, S., Goand, U. K., & Gayen, J. R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174079 · Cited by 57
Redox Regulation of Lipid Mobilization in Adipose Tissues
Abou-Rjeileh, U., & Contreras, G. A. (2021) · Antioxidants · doi:10.3390/antiox10071090 · Cited by 57
Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
Bourgeois, C., Gorwood, J., Olivo, A., Pelletier, L., Capeau, J., Lambotte, O., Béréziat, V., & Lagathu, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670566 · Cited by 51
IL-6 and diabetic kidney disease
Zhang, L., Xu, F., & Hou, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1465625 · Cited by 55
Cancer cachexia: molecular basis and therapeutic advances
Tan, Y., Xue, R., Pan, Y., he, Z., Hu, X., Li, Y., Li, K., Zhang, X., Bian, X.-W., & Wang, B. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02331-7 · Cited by 57
Adipose tissue macrophage burden, systemic inflammation, and insulin resistance
Jia, Q., Morgan-Bathke, M. E., & Jensen, M. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00109.2020 · Cited by 47
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
Bruno, M. E. C., Mukherjee, S., Powell, W. L., Mori, S. F., Wallace, F. K., Balasuriya, B. K., Su, L. C., Stromberg, A. J., Cohen, D. A., & Starr, M. E. (2022) · GeroScience · doi:10.1007/s11357-022-00572-w · Cited by 47
Obesity Programs Macrophages to Support Cancer Progression
Singh, A., Mayengbam, S. S., Yaduvanshi, H., Wani, M. R., & Bhat, M. K. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1257 · Cited by 49
Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer
Meehan, E. V., & Wang, K. (2022) · Genes · doi:10.3390/genes13091643 · Cited by 47
Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes
Gutierrez, A. D., Gao, Z., Hamidi, V., Zhu, L., Saint Andre, K. B., Riggs, K., Ruscheinsky, M., Wang, H., Yu, Y., Miller, C., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100813 · Cited by 44
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
Han, M. S., Perry, R. J., Camporez, J.-P., Scherer, P. E., Shulman, G. I., Gao, G., & Davis, R. J. (2021) · Genes & Development · doi:10.1101/gad.344556.120 · Cited by 43
Prevalence and biomarkers in metabolic syndrome
Kytikovа, O. Y., Antonyuk, M. V., Анатольевна, К. Т., Novgorodtseva, T. P., & Denisenko, Y. (2021) · Obesity and metabolism · doi:10.14341/omet12704 · Cited by 43
Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 44
Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging
Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44
“Additionally, fibroblast growth factor 21 (FGF21) is also upregulated by physical activity and may act downstream of these signals to further enhance the thermogenic program [53].”
Mitochondria Homeostasis and Oxidant/Antioxidant Balance in Skeletal Muscle—Do Myokines Play a Role?
Pang, B. P. S., Chan, W. S., & Chan, C. B. (2021) · Antioxidants · doi:10.3390/antiox10020179 · Cited by 43
Sphingosine 1-phosphate metabolism and insulin signaling
Wigger, D., Schumacher, F., Schneider‐Schaulies, S., & Kleuser, B. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109959 · Cited by 44
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure
Guardia, L. D., & Shin, A. C. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02183-6 · Cited by 42
Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study
Sforzini, L., Cattaneo, A., Ferrari, C., Turner, L., Mariani, N., Enache, D., Hastings, C. N. M., Lombardo, G., Nettis, M. A., Nikkheslat, N., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02438-x · Cited by 41
The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review
Salazar-Gómez, A., Ontiveros‐Rodríguez, J. C., Pablo-Pérez, S. S., Vargas-Dı́az, M. E., & Garduño‐Siciliano, L. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.08.020 · Cited by 44
Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain
Mintoff, D., Agius, R., Benhadou, F., Das, A., Frew, J. W., & Pace, N. P. (2023) · Clinical and Experimental Dermatology · doi:10.1093/ced/llad182 · Cited by 39
Temporal variations in the gut microbial diversity in response to high-fat diet and exercise
Imdad, S., So, B., Jang, J.-H., Park, J.-H., Lee, S., Kim, J., & Kang, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-52852-4 · Cited by 39
From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics
Korzun, T., Moses, A. S., Diba, P., Sattler, A. L., Taratula, O. R., Sahay, G., Taratula, O., & Marks, D. L. (2023) · Pharmaceuticals · doi:10.3390/ph16081088 · Cited by 40
Catalpol ameliorates doxorubicin‑induced inflammation and oxidative stress in H9C2 cells through PPAR‑γ activation
Jiang, Y., & Zhang, Q. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8743 · Cited by 36
From Influenza Virus to Novel Corona Virus (SARS-CoV-2)–The Contribution of Obesity
Bhattacharya, I., Ghayor, C., Domínguez, A. P., & Weber, F. E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.556962 · Cited by 38
Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents
Xiao, L., & Miwa, N. (2021) · Cells · doi:10.3390/cells10030626 · Cited by 34
Adipokines and Bacterial Metabolites: A Pivotal Molecular Bridge Linking Obesity and Gut Microbiota Dysbiosis to Target
Turpin, T., Thouvenot, K., & Gonthier, M. (2023) · Biomolecules · doi:10.3390/biom13121692 · Cited by 35
The Heartwarming Effect of Brown Adipose Tissue
Pinckard, K. M., & Stanford, K. I. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000328 · Cited by 33
Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
Luan, D., Dadpey, B., Zaid, J., Bridge-Comer, P. E., DeLuca, J. H., Xia, W., Castle, J., & Reilly, S. M. (2022) · Diabetes · doi:10.2337/db22-0444 · Cited by 35
Neutrophils as indicators of obesity‐associated inflammation: A systematic review and meta‐analysis
Gomez‐Casado, G., Jimenez‐Gonzalez, A., Rodríguez-Muñoz, A., Tinahones, F. J., González‐Mesa, E., Murri, M., & Ortega‐Gómez, A. (2024) · Obesity Reviews · doi:10.1111/obr.13868 · Cited by 31
Symposium review: Adipose tissue endocrinology in the periparturient period of dairy cows
Häussler, S., Sadri, H., Ghaffari, M. H., & Sauerwein, H. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21220 · Cited by 33
The diverse roles of macrophages in metabolic inflammation and its resolution
Ray, A. G., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 31
Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
Metcalfe, R. S., Kemp, R. N., Heffernan, S. M., Churm, R., Chen, Y., Ruffino, J. S., Conway, G. E., Tornillo, G., & Orange, S. T. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04680-x · Cited by 33
Hepcidin and ferritin levels as markers of immune cell activation during septic shock, severe COVID-19 and sterile inflammation
Hortová-Kohoutková, M., Skotáková, M., Onyango, I. G., Slezáková, M., Panovský, R., Opatřil, L., Slanina, P., Zuani, M. D., Mrkva, O., Andrejčinová, I., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1110540 · Cited by 28
Obesity and Inflammation: Colorectal Cancer Engines
Malhab, L. J. B., & Abdel‐Rahman, W. M. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210906122054 · Cited by 28
Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution
Alarcon, P. C., Damen, M. S. M. A., Madan, R., Deepe, G. S., Spearman, P. W., Way, S. S., & Divanovic, S. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00404-8 · Cited by 28
Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009–2010
Sun, J., Wang, W., Li, D., Song, J., Chen, Z., Chen, L., Smeets, R., Beikler, T., Strenge, J. T., Yang, Z., et al. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03189-3 · Cited by 27
Interleukin-6: An Under-Appreciated Inducer of Thermogenic Adipocyte Differentiation
Radványi, Á., & Rőszer, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052810 · Cited by 31
Cancer-triggered systemic disease and therapeutic targets
Cao, Y. (2024) · Holistic Integrative Oncology · doi:10.1007/s44178-024-00077-w · Cited by 26
Serum Lipids, Inflammation, and the Risk of Atrial Fibrillation: Pathophysiological Links and Clinical Evidence
Mauriello, A., Correra, A., Maratea, A. C., Caturano, A., Liccardo, B., Perrone, M. A., Giordano, A., Nigro, G., D’Andrea, A., & Russo, V. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051652 · Cited by 29
Immune cell–adipose tissue crosstalk in metabolic diseases with a focus on type 1 diabetes
Alzaïd, F., Fagherazzi, G., Riveline, J., Bahman, F., Al‐Rashed, F., Al‐Mulla, F., & Ahmad, R. (2025) · Diabetologia · doi:10.1007/s00125-025-06437-z · Cited by 33
Female obesity: Association with endocrine disruption and reproductive dysfunction
Baraskar, K., Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2021) · Obesity Medicine · doi:10.1016/j.obmed.2021.100375 · Cited by 27
Polycystic ovary syndrome and risks for COVID-19 infection: A comprehensive review
de Medeiros, S. F., Yamamoto, M. M. W., de Medeiros, M. A. S., Yamamoto, A. K. L. W., & Barbosa, B. B. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09715-y · Cited by 31
Unravelling the broader complexity of IL-6 involvement in health and disease
Jenkins, R. L., Hughes, S. T. O., Figueras, A. C., & Jones, S. A. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155684 · Cited by 25
Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes
Du, X., Liu, M., Tai, W., Yu, H., Hao, X., Loor, J. J., Jiang, Q., Fang, Z., Gao, X., Fan, M., et al. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-22009 · Cited by 27
Adipokines: A Rainbow of Proteins with Metabolic and Endocrine Functions
Parrettini, S., Cavallo, M., Gaggia, F., Calafiore, R., & Luca, G. (2020) · Protein and Peptide Letters · doi:10.2174/0929866527666200505214555 · Cited by 26
Effects of Salvia officinalis L. and Chamaemelum nobile (L.) extracts on inflammatory responses in two models of human cells: Primary subcutaneous adipocytes and neuroblastoma cell line (SK-N-SH)
Russo, C. A., Edwards, K. D., Margetts, G., Kleidonas, S., Zaibi, N. S., Clapham, J. C., & Zaibi, M. S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113614 · Cited by 24
Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
Martins, F. F., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2022) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2022-0044 · Cited by 28
The Involvement of Glucose and Lipid Metabolism Alteration in Rheumatoid Arthritis and Its Clinical Implication
Luo, T.-T., Wu, Y., Yin, Q., Chen, W.-G., & Zuo, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s398291 · Cited by 25
Association of baseline and changes in adiponectin, homocysteine, high-sensitivity C-reactive protein, interleukin-6, and interleukin-10 levels and metabolic syndrome incidence: Tehran lipid and glucose study
Zahedi, A. S., DANESHPOUR, M. S., Akbarzadeh, M., Hedayati, M., Azizi, F., & Zarkesh, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19911 · Cited by 24
Potentially obesogenic diets alter metabolic and neurobehavioural parameters in Wistar rats: a comparison between two dietary models
do Bonfim, T. H. F., Tavares, R. L., de Vasconcelos, M. H. A., Gouveia, M., Nunes, P. C., Soares, N. L., Alves, R. C., de Carvalho, J. L. P., Alves, A. F., Pereira, R. D. A., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.034 · Cited by 25
Adipose tissue-derived mediators of systemic inflammation and metabolic control
Alexaki, V. I. (2024) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2024.100560 · Cited by 29
Obesity–cancer axis crosstalk: Molecular insights and therapeutic approaches
Rakib, A., Mamun, M. A. A., Mandal, M., Sinha, P., & Singh, U. P. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.029 · Cited by 25
Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity
Yu, Z., Shu, W., Hou, X., & Wang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702835 · Cited by 23
Salivary Adipokine and Cytokine Levels as Potential Markers for the Development of Obesity and Metabolic Disorders
Zyśk, B., Ostrowska, L., & Smarkusz-Zarzecka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111703 · Cited by 23
Comparing the effects of tumor necrosis factor alpha, lipopolysaccharide and palmitic acid on lipid metabolism and inflammation in murine 3T3-L1 adipocytes
Jack, B. U., Mamushi, M., Viraragavan, A., Dias, S. C., & Pheiffer, C. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120422 · Cited by 23
Inactivity and obesity: consequences for macrophage-mediated inflammation and the development of cardiometabolic disease
BISHOP, N. C., Wadley, A. J., Hamrouni, M., & Roberts, M. J. (2022) · Proceedings of The Nutrition Society · doi:10.1017/s0029665122002671 · Cited by 26

Authors: Han, M. S., White, A., Perry, R. J., Camporez, J.-P., Hidalgo, J., Shulman, G. I., & Davis, R. J.
Affiliations: University of Massachusetts Chan Medical School (US)
Yale University (US)
Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520;
Universitat Autònoma de Barcelona (ES)
Corresponding author: Davis, Roger J.
ORCID: Han, Myoung Sook
Perry, Rachel J.
Hidalgo, Juan
Shulman, Gerald I.
Davis, Roger J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2020-01-24
Volume: 117
Issue: 6
Pages: 2751-2760
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1920004117
PMC: PMC7022151
OpenAlex: W3002801990
Cited by: 344
References: 37
Citations by year: 2026: 37 · 2025: 40 · 2024: 53 · 2023: 59 · 2022: 64 · 2021: 57 · 2020: 31
FWCI: 37.78
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
eScholarship@UMassChan (submittedVersion, cc-by-nc-nd)
Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc-nd)
Funders: American Heart Association (19CDA34660270)
Ministerio de Economía y Competitividad (SAF2014-56546-R, RTI2018-101105-B-I00)
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK107220, R01 DK112698, R01 DK121545, R01 DK116774, R01 DK114793, P30 DK045735)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: interleukin-6, adipose tissue inflammation, low-grade inflammation, metabolic syndrome, adipose tissue macrophages, myeloid cells, adipocytes, skeletal muscle, macrophage accumulation, immune cell infiltration
MeSH terms: ADAM10 Protein, ADAM17 Protein, Adipose Tissue, Animals, Female, Humans, Macrophages, Male, Mice, Inbred C57BL, Obesity, Species Specificity, Interleukin-6, Adipocytes, Myeloid Cells, Muscle Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of adipose tissue inflammation by interleukin 6

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks