The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: Evidence that Yfh1p affects Fe-S cluster synthesis
Open accessAbstract
Decreased expression of Yfh1p in the budding yeast, Saccharomyces cerevisiae , and the orthologous human gene frataxin results in respiratory deficiency and mitochondrial iron accumulation. The absence of Yfh1p decreases mitochondrial iron export. We demonstrate that decreased expression of Nfs1p, the yeast cysteine desulfurase that plays a central role in Fe-S cluster synthesis, also results in mitochondrial iron accumulation due to decreased export of mitochondrial iron. In the absence of Yfh1p, activity of Fe-S-containing enzymes (aconitase, succinate dehydrogenase) is decreased, whereas the activity of a non-Fe-S-containing enzyme (malate dehydrogenase) is unaffected. Aconitase protein was abundant even though the activity of aconitase was decreased in both aerobic and anaerobic conditions. These results demonstrate a direct role of Yfh1p in the formation of Fe-S clusters and indicate that mitochondrial iron export requires Fe-S cluster biosynthesis.
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“Mouse T-cell immunoglobulin-domain and mucin-domain (TIM)-2 was identified as a ferritin H subunit receptor (48)”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [48]
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“Additional experiments also showed that ferritin L did not interact with TIM-2 (48).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [48]
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“Ferritin H incorporation was not observed in the absence of TIM-2 (48).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [48]
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Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion
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Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia
Rötig, A., de Lonlay, P., Chretien, D., Foury, F., Koenig, M., Sidi, D., Munnich, A., & Rustin, P. (1997) · Nature Genetics · doi:10.1038/ng1097-215 · Cited by 991
Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin
Babcock, M., de Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., & Kaplan, J. (1997) · Science · doi:10.1126/science.276.5319.1709 · Cited by 921
Self-citationThe mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins
Kispál, G., Csere, P., Prohl, C., & Lill, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3981 · Cited by 699
Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae
Cabiscol, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003140200 · Cited by 418
CCC1 Is a Transporter That Mediates Vacuolar Iron Storage in Yeast
Li, L., Chen, O. S., Ward, D. M., & Kaplan, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103944200 · Cited by 354
Self-citationRespiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue
Wilson, R. B., & Roof, D. M. (1997) · Nature Genetics · doi:10.1038/ng0897-352 · Cited by 345
Oxidative Stress Promotes Specific Protein Damage inSaccharomyces cerevisiae
Cabiscol, E., Piulats, E., Echave, P., Herrero, E., & Ros, J. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61523-1 · Cited by 334
The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins
Mühlenhoff, U. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.17.2025 · Cited by 326
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Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 411
Mühlenhoff, U., Gerber, J., Richhardt, N., & Lill, R. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg446 · Cited by 383
Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity
Bulteau, A.-L., O’Neill, H. A., Kennedy, M. C., Ikeda‐Saito, M., Isaya, G., & Szweda, L. I. (2004) · Science · doi:10.1126/science.1098991 · Cited by 372
Metadata
- Authors
- Chen, O. S., Hemenway, S., & Kaplan, J.
- Affiliations
- University of Utah (US)
- ORCID
- Chen, Opal S.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-09-09
- Volume
- 99
- Issue
- 19
- Pages
- 12321-12326
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129443
- OpenAlex
- W2039280518
- Cited by
- 152
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 5 · 2015: 2 · 2014: 5 · 2013: 8 · 2012: 7
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 52380, R01DK052380)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- frataxin, iron-sulfur cluster assembly, mitochondrial iron accumulation, Saccharomyces cerevisiae, aconitase, succinate dehydrogenase, malate dehydrogenase, respiratory deficiency, cysteine desulfurase
- MeSH terms
- Frataxin, Aconitate Hydratase, Biological Transport, Active, Carrier Proteins, Fungal Proteins, Humans, Iron, Iron-Sulfur Proteins, Mitochondria, Oxidation-Reduction, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Sulfurtransferases, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins, Iron-Binding Proteins
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