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Avoiding pitfalls in the pursuit of a COVID-19 vaccine
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As they race to devise a vaccine, researchers are trying to ensure that their candidates don't spur a counterproductive, even dangerous, immune system reaction known as immune enhancement.
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“The initial emphasis on the T cell immunopathology model came from a Th2-bias hypothesis (Peeples, 2020) and that has not been borne out, as discussed above in the CD4+ T cell section.”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Peeples, 2020
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Metadata
- Authors
- Peeples, L.
- Corresponding author
- Peeples, Lynne
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-03-30
- Volume
- 117
- Issue
- 15
- Pages
- 8218-8221
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7165470
- OpenAlex
- W3013160031
- Cited by
- 152
- References
- 8
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 16 · 2021: 56 · 2020: 66
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- COVID-19 vaccines, immune enhancement, vaccine safety, SARS-CoV-2, vaccine candidate, immune response
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Animals, Antigens, Viral, Clinical Trials as Topic, Humans, Inflammation, Pneumonia, Viral, T-Lymphocytes, Viral Vaccines, Coronavirus Infections, Antibody-Dependent Enhancement, Severe Acute Respiratory Syndrome, Pandemics
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