The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Characterization and engineering of a two-enzyme system for plastics depolymerization
Open accessAbstract
Significance: Deconstruction of recalcitrant polymers, such as cellulose or chitin, is accomplished in nature by synergistic enzyme cocktails that evolved over millions of years. In these systems, soluble dimeric or oligomeric intermediates are typically released via interfacial biocatalysis, and additional enzymes often process the soluble intermediates into monomers for microbial uptake. The recent discovery of a two-enzyme system for polyethylene terephthalate (PET) deconstruction, which employs one enzyme to convert the polymer into soluble intermediates and another enzyme to produce the constituent PET monomers (MHETase), suggests that nature may be evolving similar deconstruction strategies for synthetic plastics. This study on the characterization of the MHETase enzyme and synergy of the two-enzyme PET depolymerization system may inform enzyme cocktail-based strategies for plastics upcycling.
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Cites
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Cited by
Varadi, M., Anyango, S., Deshpande, M., Nair, S., Natassia, C., Yordanova, G., Yuan, D., Stroe, O., Wood, G., Laydon, A., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1061 · Cited by 7,850
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Expanding plastics recycling technologies: chemical aspects, technology status and challenges
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Self-citationReducing environmental plastic pollution by designing polymer materials for managed end-of-life
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Metadata
- Authors
- Knott, B. C., Erickson, E., Allen, M. D., Gado, J. E., Graham, R., Kearns, F. L., Pardo, I., Topuzlu, E., Anderson, J. J., Austin, H. P., Dominick, G., Johnson, C. W., Rorrer, N. A., Szostkiewicz, C. J., Copié, V., Payne, C. M., Woodcock, H. L., Donohoe, B. S., Beckham, G. T., & McGeehan, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-09-28
- Volume
- 117
- Issue
- 41
- Pages
- 25476-25485
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3089916935
- Cited by
- 526
- References
- 6
- FWCI
- 27.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Knott, B. C., Erickson, E., Allen, M. D., Gado, J. E., Graham, R., Kearns, F. L., Pardo, I., Topuzlu, E., Anderson, J. J., Austin, H. P., Dominick, G., Johnson, C. W., Rorrer, N. A., Szostkiewicz, C. J., Copié, V., Payne, C. M., Woodcock, H. L., Donohoe, B. S., Beckham, G. T., & McGeehan, J. E. (2020). Characterization and engineering of a two-enzyme system for plastics depolymerization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2006753117
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