The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Purification and characterization of human DNA damage checkpoint Rad complexes
Open accessAbstract
Checkpoint Rad proteins function early in the DNA damage checkpoint signaling cascade to arrest cell cycle progression in response to DNA damage. This checkpoint ensures the transmission of an intact genetic complement to daughter cells. To learn about the damage sensor function of the human checkpoint Rad proteins, we purified a heteropentameric complex composed of hRad17-RFCp36-RFCp37-RFCp38-RFCp40 (hRad17-RFC) and a heterotrimeric complex composed of hRad9-hHus1-hRad1 (checkpoint 9-1-1 complex). hRad17-RFC binds to DNA, with a preference for primed DNA and possesses weak ATPase activity that is stimulated by primed DNA and single-stranded DNA. hRad17-RFC forms a complex with the 9-1-1 heterotrimer reminiscent of the replication factor C/proliferating cell nuclear antigen clamp loader/sliding clamp complex of the replication machinery. These findings constitute biochemical support for models regarding the roles of checkpoint Rads as damage sensors in the DNA damage checkpoint response of human cells.
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Cites
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Cited by
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Self-citationSensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498
Replication protein A-mediated recruitment and activation of Rad17 complexes
Zou, L., Liu, D., & Elledge, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336100100 · Cited by 431
Ellison, V., & Stillman, B. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000033 · Cited by 363
Metadata
- Authors
- Lindsey-Boltz, L. A., Bermudez, V. P., Hurwitz, J., & Sancar, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 20
- Pages
- 11236-11241
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061197588
- Cited by
- 198
- References
- 1
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Lindsey-Boltz, L. A., Bermudez, V. P., Hurwitz, J., & Sancar, A. (2001). Purification and characterization of human DNA damage checkpoint Rad complexes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.201373498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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