Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

Cell Cycle Control and Cancer

Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,523 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445 · see citing works

Using Antibodies: A Laboratory Manual

Harlow, E., & Lane, D. A. (1998) · Cited by 996 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Krishna, T. S. R., Kong, X., Gary, S. L., Burgers, P., & Kuriyan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90014-0 · Cited by 902 · see citing works

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824 · see citing works

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

Waga, S., & Stillman, B. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.721 · Cited by 814 · see citing works

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

Rouse, J. W., & Jackson, S. P. (2002) · Science · doi:10.1126/science.1074740 · Cited by 688 · see citing works

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

Garvik, B. M., Carson, M., & Hartwell, L. H. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6128 · Cited by 629 · see citing works

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

Waga, S., & Stillman, B. (1994) · Nature · doi:10.1038/369207a0 · Cited by 557 · see citing works

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinPreprint

Zou, L., Cortez, D., & Elledge, S. J. (2002) · Genes & Development · doi:10.1101/gad.950302 · Cited by 498 · see citing works

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429 · see citing works

Yeast Checkpoint Genes in DNA Damage Processing: Implications for Repair and Arrest

Lydall, D. A., & Weinert, T. A. (1995) · Science · doi:10.1126/science.270.5241.1488 · Cited by 416 · see citing works

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

Melo, J. A., Cohen, J., & Toczyski, D. P. (2001) · Genes & Development · doi:10.1101/gad.903501 · Cited by 384 · see citing works

Replication factors required for SV40 DNA replication in vitro. I. DNA structure-specific recognition of a primer-template junction by eukaryotic DNA polymerases and their accessory proteins

Tsurimoto, T., & Stillman, B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52385-1 · Cited by 381 · see citing works

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex <i>in vitro</i>

Bermudez, V. P., Lindsey-Boltz, L. A., Cesare, A. J., Maniwa, Y., Griffith, J. D., Hurwitz, J., & Sancar, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437927100 · Cited by 324 · see citing works

Crystal Structure of the Processivity Clamp Loader Gamma (γ) Complex of E. coli DNA Polymerase III

Jeruzalmi, D., O’Donnell, M. E., & Kuriyan, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00463-9 · Cited by 322 · see citing works

Identification of RFC(Ctf18p, Ctf8p, Dcc1p)

Mayer, M. L., Gygi, S. P., Aebersold, R. H., & Hieter, P. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00254-4 · Cited by 319 · see citing works

PCNA connects DNA replication to epigenetic inheritance in yeast

Zhang, Z., Shibahara, K., & Stillman, B. (2000) · Nature · doi:10.1038/35041601 · Cited by 318 · see citing works

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

Venclovas, Č., & Thelen, M. P. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2481 · Cited by 268 · see citing works

Functions of replication factor C and proliferating-cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4.

Tsurimoto, T., & Stillman, B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1023 · Cited by 260 · see citing works

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III

Jeruzalmi, D., Yurieva, O., Zhao, Y., Young, M. A., Stewart, J., Hingorani, M., O’Donnell, M. E., & Kuriyan, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00462-7 · Cited by 260 · see citing works

Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms

Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., & Sugimoto, K. (2001) · Science · doi:10.1126/science.1063827 · Cited by 258 · see citing works

Sliding Clamps of DNA Polymerases

Kuriyan, J., & O’Donnell, M. E. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1644 · Cited by 258 · see citing works

Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint

Majka, J., & Burgers, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437148100 · Cited by 255 · see citing works

DNA Damage and Checkpoint Pathways

Weinert, T. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81597-4 · Cited by 253 · see citing works

Characterization of the Five Replication Factor C Genes of Saccharomyces cerevisiae

Cullmann, G., Fien, K., Kobayashi, R., & Stillman, B. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4661 · Cited by 245 · see citing works

Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9

Caspari, T., Dahlén, M., Kanter-Smoler, G., Lindsay, H. D., Hofmann, K., Papadimitriou, K., Sunnerhagen, P., & Carr, A. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1254-1262.2000 · Cited by 231 · see citing works

The internal workings of a DNA polymerase clamp‐loading machine

Turner, J., Hingorani, M., Kelman, Z., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.771 · Cited by 215 · see citing works

Multiple competition reactions for RPA order the assembly of the DNA polymerase δ holoenzyme

Yuzhakov, A., Kelman, Z., Hurwitz, J., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6189 · Cited by 212 · see citing works

Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro.

Tsurimoto, T., & Stillman, B. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.609 · Cited by 210 · see citing works

A novel Rad24 checkpoint protein complex closely related to replication factor C

Green, C., Erdjument‐Bromage, H., Tempst, P., & Lowndes, N. F. (2000) · Current Biology · doi:10.1016/s0960-9822(99)00263-8 · Cited by 208 · see citing works

Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.

Griffiths, D. J. F., Barbet, N., McCready, S. J., Lehmann, A. R., & Carr, A. M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00269.x · Cited by 204 · see citing works

Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

Lee, J., Kumagai, A., & Dunphy, W. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00045-5 · Cited by 199 · see citing works

Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex

Volkmer, E., & Karnitz, L. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.567 · Cited by 198 · see citing works

Purification and characterization of human DNA damage checkpoint Rad complexes

Lindsey‐Boltz, L. A., Bermudez, V. P., Hurwitz, J., & Sancar, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201373498 · Cited by 198 · see citing works

Devoted to the lagging strand—the χ subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly

Kelman, Z., Yuzhakov, A., Andjelkovic, J., & O’Donnell, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2436 · Cited by 188 · see citing works

Lcd1p Recruits Mec1p to DNA Lesions In Vitro and In Vivo

Rouse, J. W., & Jackson, S. P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00507-5 · Cited by 179 · see citing works

The χψ Subunits of DNA Polymerase III Holoenzyme Bind to Single-stranded DNA-binding Protein (SSB) and Facilitate Replication of an SSB-coated Template

Glover, B. P., & McHenry, C. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23476 · Cited by 167 · see citing works

Clamping down on clamps and clamp loaders

Mossi, R., & Hübscher, U. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.254209.x · Cited by 164 · see citing works

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

Bellaoui, M., Chang, M., Ou, J., Xu, H., Boone, C., & Brown, G. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg406 · Cited by 157 · see citing works

A Sliding Clamp Model for the Rad1 Family of Cell Cycle Checkpoint Proteins

Thelen, M. P., Venclovas, Č., & Fidelis, K. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80587-5 · Cited by 150 · see citing works

The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

Longhese, M. P., Paciotti, V., Fraschini, R., Zaccarini, R., Plevani, P., & Lucchini, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5216 · Cited by 149 · see citing works

Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex

Burtelow, M. A., Roos‐Mattjus, P., Rauen, M. P., Babendure, J. R., & Karnitz, L. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102946200 · Cited by 142 · see citing works

The Human G2 Checkpoint Control Protein hRAD9 Is a Nuclear Phosphoprotein That Forms Complexes with hRAD1 and hHUS1

St.Onge, R. P., Udell, C. M., Casselman, R., & Davey, S. K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1985 · Cited by 141 · see citing works

ATP Binding to the Escherichia coli Clamp Loader Powers Opening of the Ring-shaped Clamp of DNA Polymerase III Holoenzyme

Hingorani, M., & O’Donnell, M. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24550 · Cited by 141 · see citing works

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

Paciotti, V., Lucchini, G., Plevani, P., & Longhese, M. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4199 · Cited by 132 · see citing works

Role of a Complex Containing Rad17, Mec3, and Ddc1 in the Yeast DNA Damage Checkpoint Pathway

Kondo, T., Matsumoto, K., & Sugimoto, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1136 · Cited by 126 · see citing works

Replication factor A is required in vivo for DNA replication, repair, and recombination.

Longhese, M. P., Plevani, P., & Lucchini, G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7884 · Cited by 125 · see citing works

Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae

Kim, H., & Brill, S. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3725-3737.2001 · Cited by 121 · see citing works

ELG1 , a yeast gene required for genome stability, forms a complex related to replication factor C

Ben‐Aroya, S., Koren, A., Liefshitz, B., Steinlauf, R., & Kupiec, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1633757100 · Cited by 118 · see citing works

ATP Utilization by Yeast Replication Factor C

Gomes, X. V., Schmidt, S. L. G., & Burgers, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011743200 · Cited by 117 · see citing works

The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint

You, Z., Kong, L., & Newport, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204120200 · Cited by 114 · see citing works

Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage

Kostrub, C. F., Knudsen, K. E., Subramani, S. E., & Enoch, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2055 · Cited by 114 · see citing works

Mammalian DNA Polymerase Auxiliary Proteins: Analysis of Replication Factor C-Catalyzed Proliferating Cell Nuclear Antigen Loading onto Circular Double-Stranded DNA

Podust, L. M., Podust, V. N., Sogo, J. M., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3072 · Cited by 100 · see citing works

Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response

Brush, G. S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.19.3725 · Cited by 98 · see citing works

Rfc5, a Replication Factor C Component, Is Required for Regulation of Rad53 Protein Kinase in the Yeast Checkpoint Pathway

Sugimoto, K., Ando, S., Shimomura, T., & Matsumoto, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5905 · Cited by 92 · see citing works

UV-induced Hyperphosphorylation of Replication Protein A Depends on DNA Replication and Expression of ATM Protein

Oakley, G. G., Loberg, L. I., Yao, J., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P., & Dixon, K. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1199 · Cited by 91 · see citing works

Functional and Physical Interaction between Rad24 and Rfc5 in the Yeast Checkpoint Pathways

Shimomura, T., Ando, S., Matsumoto, K., & Sugimoto, K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5485 · Cited by 82 · see citing works

Purification of a Cellular Replication Factor, RF-C, That Is Required for Coordinated Synthesis of Leading and Lagging Strands during Simian Virus 40 DNA Replication In Vitro

Tsurimoto, T., & Stillman, B. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.609-619.1989 · Cited by 82 · see citing works

Cyclin-Dependent Kinase Inhibitor p21 Modulates the DNA Primer-Template Recognition Complex

Waga, S., & Stillman, B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4177 · Cited by 78 · see citing works

A Complex Consisting of Human Replication Factor C p40, p37, and p36 Subunits Is a DNA-dependent ATPase and an Intermediate in the Assembly of the Holoenzyme

Cai, J., Gibbs, E., Uhlmann, F., Phillips, B., Yao, N. Y., O’Donnell, M. E., & Hurwitz, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18974 · Cited by 71 · see citing works

Division of labor—sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA

Hingorani, M., Bloom, L. B., Goodman, M. F., & O’Donnell, M. E. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5131 · Cited by 68 · see citing works

Checkpoint Proteins Influence Telomeric Silencing and Length Maintenance in Budding Yeast

Longhese, M. P., Paciotti, V., Neecke, H., & Lucchini, G. (2000) · Genetics · doi:10.1093/genetics/155.4.1577 · Cited by 68 · see citing works

Detecting the ability of viral, bacterial and eukaryotic replication proteins to track along DNA.

Tinker, R. L., Kassavetis, G. A., & Geiduschek, E. P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06867.x · Cited by 67 · see citing works

Reconstitution of Recombinant Human Replication Factor C (RFC) and Identification of an RFC Subcomplex Possessing DNA-dependent ATPase Activity

Ellison, V., & Stillman, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5979 · Cited by 59 · see citing works

Replication Factor A Is Required In Vivo for DNA Replication, Repair, and Recombination

Longhese, M. P., Plevani, P., & Lucchini, G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7884-7890.1994 · Cited by 59 · see citing works

Functional Interactions among the Subunits of Replication Factor C Potentiate and Modulate Its ATPase Activity

Podust, V. N., Tiwari, N., Ott, R., & Fanning, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12935 · Cited by 47 · see citing works

Fission Yeast Rad17 Associates with Chromatin in Response to Aberrant Genomic Structures

Kai, M., Tanaka, H., & Wang, T. S. ‐. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3289-3301.2001 · Cited by 46 · see citing works

Fission Yeast Rad26 Is a Regulatory Subunit of the Rad3 Checkpoint Kinase

Wolkow, T. D., & Enoch, T. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-03-0104 · Cited by 43 · see citing works

HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV Irradiation

Chang, M.-S., Sasaki, H., Campbell, M. S., Kraeft, S., Sutherland, R., Yang, C., Liu, Y., Auclair, D., Hao, L., Sonoda, H., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36544 · Cited by 39 · see citing works

Dissection of the ATP-driven reaction cycle of the bacteriophage T4 DNA replication processivity clamp loading system

Pietroni, P., Young, M. C., Latham, G. J., et al. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4687 · Cited by 39 · see citing works

Dynamics of β and Proliferating Cell Nuclear Antigen Sliding Clamps in Traversing DNA Secondary Structure

Yao, N. Y., Hurwitz, J., & O’Donnell, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1421 · Cited by 39 · see citing works

DNA Structure Requirements for the Escherichia coliγ Complex Clamp Loader and DNA Polymerase III Holoenzyme

Yao, N. Y., Leu, F. P., Anjelkovic, J., Turner, J., & O’Donnell, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11440 · Cited by 37 · see citing works

Escherichia coli DNA Polymerase III Holoenzyme Subunits α, β, and γ Directly Contact the Primer-Template

Reems, J. A., Wood, S., & McHenry, C. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5606 · Cited by 36 · see citing works

Assembly of Functional Replication Factor C Expressed Using Recombinant Baculoviruses

Podust, V. N., & Fanning, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6303 · Cited by 32 · see citing works

Mechanism of Bacteriophage T4 DNA Holoenzyme Assembly: The 44/62 Protein Acts as a Molecular Motor

Berdis, A. J., & Benkovic, S. J. (1997) · Biochemistry · doi:10.1021/bi962139l · Cited by 24 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes &amp; Development · doi:10.1101/gad.1301205 · Cited by 767 · see citing works

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell · doi:10.1016/j.cell.2004.06.023 · Cited by 544 · see citing works

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

Maréchal, A., & Zou, L. (2015) · Cell Research · doi:10.1038/cr.2014.147 · Cited by 465 · see citing works

Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex

Parrilla-Castellar, E. R., Arlander, S. J. H., & Karnitz, L. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.032 · Cited by 342 · see citing works

ATR signalling: more than meeting at the fork

Nam, E. A., & Cortez, D. (2011) · Biochemical Journal · doi:10.1042/bj20102162 · Cited by 316 · see citing works

Replication Protein A phosphorylation and the cellular response to DNA damage

Binz, S. K., Sheehan, A. M., & Wold, M. S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.028 · Cited by 299 · see citing works

ATR: a master conductor of cellular responses to DNA replication stress

Flynn, R. L., & Zou, L. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.09.005 · Cited by 290 · see citing works

ATR autophosphorylation as a molecular switch for checkpoint activation

Liu, S., Shiotani, B., Lahiri, M., Maréchal, A., Tse, A., Leung, C. C. Y., Glover, J. N. M., Yang, X. H., & Zou, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.019 · Cited by 281 · see citing works

Common mechanisms of PIKK regulation

Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.006 · Cited by 277 · see citing works

The structural determinants of checkpoint activation

MacDougall, C. A., Byun, T. S., Van, C., Yee, M.-C., & Cimprich, K. A. (2007) · Genes &amp; Development · doi:10.1101/gad.1522607 · Cited by 240 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Replication Protein A Directs Loading of the DNA Damage Checkpoint Clamp to 5′-DNA Junctions

Majka, J., Binz, S. K., Wold, M. S., & Burgers, P. M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605176200 · Cited by 205 · see citing works

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

Majka, J., Niedziela-Majka, A., & Burgers, P. M. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.027 · Cited by 186 · see citing works

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

Bonilla, C. Y., Melo, J. A., & Toczyski, D. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.023 · Cited by 161 · see citing works

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Finn, K., Lowndes, N. F., & Grenon, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0875-3 · Cited by 127 · see citing works

The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase   and increases its DNA substrate utilisation efficiency: implications for DNA repair

Toueille, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh652 · Cited by 122 · see citing works

Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase

Navadgi-Patil, V. M., & Burgers, P. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807435200 · Cited by 121 · see citing works

Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells

Wu, X., Shell, S. M., & Zou, Y. (2005) · Oncogene · doi:10.1038/sj.onc.1208674 · Cited by 113 · see citing works

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

Yan, S., & Michael, W. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810185 · Cited by 107 · see citing works

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113 · see citing works

UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways

Vrouwe, M. G., Pines, A., Overmeer, R. M., Hanada, K., & Mullenders, L. H. F. (2011) · Journal of Cell Science · doi:10.1242/jcs.075325 · Cited by 100 · see citing works

The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1

Wang, W., Brandt, P., Rossi, M. L., Lindsey-Boltz, L., Podust, V., Fanning, E., Sancar, A., & Bambara, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407686101 · Cited by 98 · see citing works

A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

Navadgi-Patil, V. M., & Burgers, P. M. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.03.011 · Cited by 93 · see citing works

The RFC Clamp Loader: Structure and Function

Yao, N. Y., & O’Donnell, M. (2012) · Subcellular Biochemistry · doi:10.1007/978-94-007-4572-8_14 · Cited by 90 · see citing works

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.

Cortez, D. (2005) · Genes &amp; Development · doi:10.1101/gad.1316905 · Cited by 84 · see citing works

The Two DNA Clamps Rad9/Rad1/Hus1 Complex and Proliferating Cell Nuclear Antigen Differentially Regulate Flap Endonuclease 1 Activity

Friedrich-Heineken, E., Toueille, M., Tännler, B., Bürki, C., Ferrari, E., Hottiger, M. O., & Hübscher, U. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.018 · Cited by 76 · see citing works

The human checkpoint sensor and alternative DNA clamp Rad9–Rad1–Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

SMIRNOVA, E., TOUEILLE, M., MARKKANEN, E., & HÜBSCHER, U. (2005) · Biochemical Journal · doi:10.1042/bj20050211 · Cited by 74 · see citing works

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates NEIL1 glycosylase

Guan, X., Bai, H., Shi, G., Theriot, C. A., Hazra, T. K., Mitra, S., & Lu, A.-L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm075 · Cited by 74 · see citing works

The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase   in long patch base excision repair

Gembka, A., Toueille, M., Smirnova, E., Poltz, R., Ferrari, E., Villani, G., & Hubscher, U. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1139 · Cited by 74 · see citing works

Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

Jiang, G., & Sancar, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.39-49.2006 · Cited by 70 · see citing works

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

Guan, X., Madabushi, A., Chang, D.-Y., Fitzgerald, M. E., Shi, G., Drohat, A. C., & Lu, A.-L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm678 · Cited by 65 · see citing works

Postreplication gaps at UV lesions are signals for checkpoint activation

Callegari, A. J., Clark, E., Pneuman, A., & Kelly, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003449107 · Cited by 54 · see citing works

UV irradiation induces a postreplication DNA damage checkpoint

Callegari, A. J., & Kelly, T. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607343103 · Cited by 51 · see citing works

Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex

Wang, W., Lindsey-Boltz, L. A., Sancar, A., & Bambara, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602289200 · Cited by 49 · see citing works

DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex

Hwang, B.-J., Gonzales, R., Corzine, S., Stenson, E., Pidugu, L., & Lu, A.-L. (2022) · PLOS ONE · doi:10.1371/journal.pone.0272645 · Cited by 9 · see citing works

Structure-Function Relationship of the Eukaryotic DNA Replication Factor, Proliferating Cell Nuclear Antigen

Fukuda, K., Morioka, H., Imajou, S., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22527 · Cited by 167 · see citing works

Isolation of Recombinant DNA Elongation Proteins

van Loon, B., Ferrari, E. S., & Hübscher, U. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-815-7_19 · Cited by 5 · see citing works

The HPV E2 Transcriptional Transactivation Protein Stimulates Cellular DNA Polymerase Epsilon

Chojnacki, M., & Melendy, T. (2018) · Viruses · doi:10.3390/v10060321 · Cited by 11 · see citing works

Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε

Acharya, N., Prakash, L., & Prakash, S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102727 · Cited by 6 · see citing works

Identification of Replication Factor C from Saccharomyces cerevisiae: A Component of the Leading-Strand DNA Replication Complex

Fien, K., & Stillman, B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.155-163.1992 · Cited by 55 · see citing works