The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Reversed-engineered human alveolar lung-on-a-chip model
Open accessAbstract
Significance: This work reports the development of a physiologically relevant human alveolar lung-on-a-chip model, composed of a three-dimensional (3D) porous hydrogel made of gelatin methacryloyl (GelMA) featuring an inverse opal structure, bonded to a compartmentalized chip device that provides air–liquid interface and cyclic breathing motions. Significantly, this GelMA structure has a high similarity to native human alveolar sacs in that they both possess sac-like pores and interconnecting windows between the sacs, in addition to a stiffness similar to the native human distal lung. We showed through multiscale analyses that our 3D GelMA inverse opal structure was better able to maintain the functions of primary human alveolar epithelial cells in a more in vivo-like manner compared with planar models.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
The biology and management of non-small cell lung cancer
Herbst, R. S., Morgensztern, D., & Boshoff, C. (2018) · Nature · doi:10.1038/nature25183 · Cited by 4,891
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
The Flaws and Human Harms of Animal Experimentation
AKHTAR, A. (2015) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180115000079 · Cited by 527 · cited 1×
“This has resulted in a lack of progress in drug development in respiratory medicine, with only a handful of new drugs entering clinical use in the last 50 y (9).”
BackgroundD'Erchia, A. M., Atlante, A., Gadaleta, G., Pavesi, G., Chiara, M., De Virgilio, C., Manzari, C., Mastropasqua, F., Prazzoli, G. M., Picardi, E., et al. (2015) · Mitochondrion · doi:10.1016/j.mito.2014.10.005 · Cited by 197
Mabry, K. M., Payne, S. Z., & Anseth, K. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.035 · Cited by 124
Cited by
Organoids: The current status and biomedical applications
Yang, S., Hu, H., Kung, H., Zou, R., Dai, Y., Hu, Y., Wang, T., Lv, T., Yu, J., & Li, F. (2023) · MedComm · doi:10.1002/mco2.274 · Cited by 266
Bai, H., Si, L., Jiang, A., Belgur, C., Zhai, Y., Plebani, R., Oh, C. Y., Rodas, M., Patil, A., Nurani, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29562-4 · Cited by 171
Basement membrane properties and their recapitulation in organ-on-chip applications
Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100301 · Cited by 57
Self-citationSensors-integrated organ-on-a-chip for biomedical applications
Chen, H., Luo, Z., Lin, X., Zhu, Y., & Zhao, Y. (2023) · Nano Research · doi:10.1007/s12274-023-5651-9 · Cited by 47
Skin models of cutaneous toxicity, transdermal transport and wound repair
Vilela de Sousa, I., Ferreira, M. J. S., Bebiano, L. B., Simões, S., Matos, A. F., Pereira, R. F., & Granja, P. L. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad014 · Cited by 17
Metadata
- Authors
- Huang, D., Liu, T., Liao, J., Maharjan, S., Xie, X., Pérez, M., Anaya, I., Wang, S., Tirado Mayer, A., Kang, Z., Kong, W., Mainardi, V. L., Garciamendez-Mijares, C. E., García Martínez, G., Moretti, M., Zhang, W., Gu, Z., Ghaemmaghami, A. M., & Zhang, Y. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2021-05-03
- Volume
- 118
- Issue
- 19
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3158636380
- Cited by
- 250
- References
- 8
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Reversed-engineered human alveolar lung-on-a-chip model. https://app.cochat.ai/papers/10.1073/pnas.2016146118
- The paper
- Huang, D., Liu, T., Liao, J., Maharjan, S., Xie, X., Pérez, M., Anaya, I., Wang, S., Tirado Mayer, A., Kang, Z., Kong, W., Mainardi, V. L., Garciamendez-Mijares, C. E., García Martínez, G., Moretti, M., Zhang, W., Gu, Z., Ghaemmaghami, A. M., & Zhang, Y. S. (2021). Reversed-engineered human alveolar lung-on-a-chip model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2016146118
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
