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Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

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Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer

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Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy

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HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

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The evolution of MDM2 family genes

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PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit Inflammatory Signaling by Promoting Degradation of the p65 Subunit of NF-κB

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Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1

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The exportomer: the peroxisomal receptor export machinery

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Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges

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Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53

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A Small-Molecule p53 Activator Induces Apoptosis through Inhibiting MDMX Expression in Breast Cancer Cells

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Deregulated signalling networks in human brain tumours

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Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility

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Symmetry and Asymmetry of the RING–RING Dimer of Rad18

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Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

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Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer

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Pharmaceutical applications of cyclotides

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2,3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

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Targeting RING domains of Mdm2–MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells

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MicroRNAs as Key Effectors in the p53 Network

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Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A–RAD18 ternary complex

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Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

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Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer

Swetzig, W. M., Wang, J., & Das, G. M. (2016) · Oncotarget · doi:10.18632/oncotarget.7533 · Cited by 44

Targeting P53 as a Future Strategy to Overcome Gemcitabine Resistance in Biliary Tract Cancers

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Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength

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A small-molecule inhibitor of MDMX suppresses cervical cancer cells via the inhibition of E6-E6AP-p53 axis

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SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

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MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy

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Anatomy of Mdm2 and Mdm4 in evolution

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MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo

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MDM4 (MDMX) and its Transcript Variants

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Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

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PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Yano, K., Takahashi, R., Shiotani, B., Abe, J., Shidooka, T., Sudo, Y., Yamamoto, Y., Kan, S., Sakagami, H., & Tahara, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100882 · Cited by 42

MDM2 and MDMX in Cancer and Development

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Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System

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Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2

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Inflammatory Angiogenesis and the Tumor Microenvironment as Targets for Cancer Therapy and Prevention

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MDM4 SNP34091 (rs4245739) and its effect on breast‐, colon‐, lung‐, and prostate cancer risk

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The Basally Expressed p53-Mediated Homeostatic Function

Nagpal, I., & Yuan, Z.-M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.775312 · Cited by 35

The roles of MDM2 and MDMX phosphorylation in stress signaling to p53

Chen, J. (2012) · Genes & Cancer · doi:10.1177/1947601912454733 · Cited by 33

MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

Chinnam, M., Xu, C., Lama, R., Zhang, X., Cedeno, C. D., Wang, Y., Stablewski, A. B., Goodrich, D. W., & Wang, X. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010171 · Cited by 35

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

Doleželová, P., Cetkovská, K., Vousden, K. H., & Uldrijan, S. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19445 · Cited by 33

Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase Cβ

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Abnormal MDMX degradation in tumor cells due to ARF deficiency

Li, X., Gilkes, D., Li, B., Cheng, Q., Pernazza, D., Lawrence, H., Lawrence, N., & Chen, J. (2012) · Oncogene · doi:10.1038/onc.2011.534 · Cited by 32

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Ohtsubo, C., Shiokawa, D., Kodama, M., Gaiddon, C., Nakagama, H., Jochemsen, A. G., Taya, Y., & Okamoto, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01180.x · Cited by 32

Inhibitors of MDM2 and MDMX: A Structural Perspective

Riedinger, C., & McDonnell, J. M. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.75 · Cited by 32

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome

Boultwood, J., Pellagatti, A., & Wainscoat, J. S. (2011) · Advances in Biological Regulation · doi:10.1016/j.advenzreg.2011.09.008 · Cited by 32

Stochastic Modeling and Simulation of the p53-MDM2/MDMX Loop

Cai, X., & Yuan, Z.-M. (2009) · Journal of Computational Biology · doi:10.1089/cmb.2008.0231 · Cited by 32

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer

Kulkarni, D. A., Vázquez, A., Haffty, B. G., Bandera, E. V., Hu, W., Sun, Y., Toppmeyer, D., Levine, A. J., & Hirshfield, K. M. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp224 · Cited by 33

MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4

Wang, Q., Selth, L. A., & Callen, D. F. (2017) · Oncotarget · doi:10.18632/oncotarget.15530 · Cited by 34

De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation

Ducker, C. E., Chow, L. K. Y., Saxton, J., Handwerger, J., McGregor, A., Strahl, T., Layfield, R., & Shaw, P. E. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz166 · Cited by 32

Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

Naderi, E. H., Jochemsen, A. G., Blomhoff, H. K., & Naderi, S. (2011) · Neoplasia · doi:10.1593/neo.11542 · Cited by 33

Overexpression of SKI Oncoprotein Leads to p53 Degradation through Regulation of MDM2 Protein Sumoylation

Ding, B., Sun, Y., & Huang, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.301523 · Cited by 31

c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation

Waning, D. L., Lehman, J. A., Batuello, C. N., & Mayo, L. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.183012 · Cited by 30

Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase*

Iyappan, S., Wollscheid, H.-P., Rojas‐Fernández, A., Marquardt, A., Tang, H., Singh, R. K., & Scheffner, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115113 · Cited by 29

Effects of MdmX on Mdm2‐mediated downregulation of pRB

Uchida, C., Miwa, S., Isobe, T., Kitagawa, K., Hattori, T., Oda, T., Yasuda, H., & Kitagawa, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.02.029 · Cited by 28

CHIP-dependent p53 regulation occurs specifically during cellular senescence

Sisoula, C., Trachana, V., Patterson, C., & Gonos, E. S. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.701 · Cited by 29

Ubiquitin and Ubiquitin-Like Proteins in the Nucleolus: Multitasking Tools for a Ribosome Factory

Shcherbik, N., & Pestov, D. G. (2010) · Genes & Cancer · doi:10.1177/1947601910381382 · Cited by 26

MDMX exerts its oncogenic activity via suppression of retinoblastoma protein

Zhang, H., Hu, L., Qiu, W., Deng, T., Zhang, Y., Bergholz, J. S., & Xiao, Z.-X. (2015) · Oncogene · doi:10.1038/onc.2015.11 · Cited by 26

The Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic Target

Fierabracci, A., & Pellegrino, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121975 · Cited by 26

Calculation of hot spots for protein–protein interaction in p53/PMI‐MDM2/MDMX complexes

Huang, D., Qi, Y., Song, J., & Zhang, J. Z. H. (2018) · Journal of Computational Chemistry · doi:10.1002/jcc.25592 · Cited by 26

High levels of Hdmx promote cell growth in a subset of uveal melanomas.

de Lange, J., Teunisse, A. F. A. S., Vries, M. V., Lodder, K., Lam, S., Luyten, G. P. M., Bernal, F., Jager, M. J., & Jochemsen, A. G. (2012) · Europe PMC (PubMed Central) · Cited by 26

Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene

Lam, S., Wiercinska, E., Teunisse, A. F. A. S., Lodder, K., ten Dijke, P., & Jochemsen, A. G. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3147-8 · Cited by 26

The Functional TP53 rs1042522 and MDM4 rs4245739 Genetic Variants Contribute to Non-Hodgkin Lymphoma Risk

Fan, C., Wei, J., Yuan, C., Wang, X., Jiang, C., Zhou, C., & Yang, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107047 · Cited by 26

Activation of p53 and destabilization of androgen receptor by combinatorial inhibition of MDM2 and MDMX in prostate cancer cells

Chopra, H., Khan, Z. A., Contreras, J., Wang, H., Sedrak, A., & Zhu, Y. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.23569 · Cited by 25

Mdm4 supports DNA replication in a p53-independent fashion

Wohlberedt, K., Klusmann, I., Derevyanko, P. K., Henningsen, K. M., Choo, J. A. M. Y., Manzini, V., Magerhans, A., Giansanti, C., Eischen, C. M., Jochemsen, A. G., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1325-1 · Cited by 27

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

Wade, M. R., Li, Y. C., Matani, A. S., Braun, S. M. G., Milanesi, F., Rodewald, L. W., & Wahl, G. M. (2012) · Oncogene · doi:10.1038/onc.2011.625 · Cited by 25

Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis

Gannon, H., & Jones, S. N. (2012) · Genes & Cancer · doi:10.1177/1947601912455324 · Cited by 25

The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer

Gansmo, L. B., Bjørnslett, M., Halle, M. K., Salvesen, H. B., Dørum, A., Birkeland, E. E., Hveem, K., Romundstad, P., VATTEN, L. J., Lønning, P. E., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-4940-2 · Cited by 25

Induction of senescence in cancer cells by 5′-Aza-2′-deoxycytidine: Bioinformatics and experimental insights to its targets

Putri, J. F., Widodo, N., Sakamoto, K., Kaul, S. C., & Wadhwa, R. (2017) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2017.08.003 · Cited by 25

Stress-Induced Alternative Splice Forms of MDM2 and MDMX Modulate the p53-Pathway in Distinct Ways

Jacob, A. G., Singh, R. K., Comiskey, D. F., Rouhier, M. F., Mohammad, F., Bebee, T. W., & Chandler, D. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104444 · Cited by 24

Cross‐talk between Myc and p53 in B‐cell lymphomas

Li, Y., Yu, T., & Young, K. H. (2019) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2019.08.001 · Cited by 27

Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM 4 and MDM 2 in colon and gastric cancer cells

Imanishi, M., Yamamoto, Y., Wang, X., Sugaya, A., Hirose, M., Endo, S., Natori, Y., Yamato, K., & Hyodo, I. (2018) · Cancer Science · doi:10.1111/cas.13893 · Cited by 24

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

Chua, J. S., Liew, H. P., Guo, L., & Lane, D. P. (2015) · Oncogene · doi:10.1038/onc.2015.57 · Cited by 24

The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review

Jiang, H., Luo, J., & Lei, H. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2021.108910 · Cited by 23

XI-006 induces potent p53-independent apoptosis in Ewing sarcoma

Pishas, K. I., Adwal, A., Neuhaus, S. J., Clayer, M., Farshid, G., Staudacher, A. H., & Callen, D. F. (2015) · Scientific Reports · doi:10.1038/srep11465 · Cited by 23

HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis

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The enigmatic oncogene and tumor suppressor‐like properties of RAD54B: Insights into genome instability and cancer

McAndrew, E. N., & McManus, K. J. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22458 · Cited by 22

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas

Bozzi, F., Conca, E., Laurini, E., Posocco, P., Sardo, A. L., Jocollé, G., Sanfilippo, R. G., Gronchi, A., Perrone, F., Tamborini, E., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.107 · Cited by 20

Mouse modelling of the MDM2/MDMX−p53 signalling axis

Tackmann, N. R., & Zhang, Y. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx006 · Cited by 21

Modification of MDMX by sumoylation

Pan, Y., & Chen, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.012 · Cited by 20

Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex

Gerarduzzi, C., de Polo, A., Liu, X.-S., El Kharbili, M., Little, J. B., & Yuan, Z.-M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.752303 · Cited by 19

MDM4 alternative splicing and implication in MDM4 targeted cancer therapies.

Wu, J., Lu, G., & Wang, X. (2021) · PubMed Central · Cited by 19

A Fluorescent-Based High-Throughput Screening Assay for Small Molecules That Inhibit the Interaction of MdmX with p53

Tsuganezawa, K., Nakagawa, Y., Kato, M., Taruya, S., Takahashi, F., Endoh, M., Utata, R., Mori, M., Ogawa, N., Honma, T., et al. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112460729 · Cited by 19

Overexpression of Mdm2 and MdmX Fusion Proteins Alters p53 Mediated Transactivation, Ubiquitination, and Degradation

Ghosh, M., Keven, H., & Berberich, S. J. (2003) · Biochemistry · doi:10.1021/bi0271291 · Cited by 22

Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism

Calderón-González, K. G., Medina‐Medina, I., Hároníková, L., Hernychová, L., Bonczek, O., Uhrík, L., Hrabal, V., Vojtěšek, B., Fåhræus, R., Hernández‐Monge, J., et al. (2022) · Bioscience Reports · doi:10.1042/bsr20220186 · Cited by 6

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2

de Graaf, P., Little, N. A., Ramos, Y. F. M., Meulmeester, E., Letteboer, S. J. F., & Jochemsen, A. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213034200 · Cited by 143

Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus

Ni, Y., Chen, H., Cheng, X., Sun, B., Wu, Z., Zhan, Q., & Zhuang, Z. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114185

Hdmx Stabilizes Mdm2 and p53

Stad, R., Ramos, Y. F. M., Little, N., Grivell, S., Attema, J., van der Eb, A. J., & Jochemsen, A. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003496200 · Cited by 145