Cited by 325Neuropeptides and Animal PhysiologyGastrointestinal motility and disordersCongenital gastrointestinal and neural anomalies

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Modulation of specific intestinal epithelial progenitors by enteric neurons

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Bjerknes, Matthew, Cheng, Hazel·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.211278098PMC PMC60082

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Abstract

The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetrodotoxin) back to the epithelium. Thus the nervous system is a key component of a feedback loop regulating epithelial growth and repair.

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Authors: Bjerknes, M., & Cheng, H.
Affiliations: University of Toronto (CA)
ORCID: Bjerknes, Matthew
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-09-25
Volume: 98
Issue: 22
Pages: 12497-12502
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.211278098
PMC: PMC60082
OpenAlex: W1987513354
Cited by: 325
References: 38
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
FWCI: 6.75
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Amgen
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: glucagon-like peptide-2, GLP-2 receptor, enteric neurons, tetrodotoxin, voltage-gated sodium channels, gut-brain signaling
MeSH terms: Glucagon-Like Peptide-1 Receptor, Animals, Glucagon-Like Peptides, Intestinal Mucosa, Neurons, Peptides, Stem Cells, Tetrodotoxin, Genes, fos, Receptors, Glucagon, Mice, Glucagon-Like Peptide 2

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Modulation of specific intestinal epithelial progenitors by enteric neurons

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