The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Modulation of specific intestinal epithelial progenitors by enteric neurons
Open accessAbstract
The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetrodotoxin) back to the epithelium. Thus the nervous system is a key component of a feedback loop regulating epithelial growth and repair.
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“Indeed, GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine (20,51,52) and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner (52).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [52]
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Core, L. D., Grzegorczyk, M. A., & Wit, E. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.31.494100
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Core, L. D., Pellin, D., Wit, E. C., & Grzegorczyk, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26593643
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Metadata
- Authors
- Bjerknes, M., & Cheng, H.
- Affiliations
- University of Toronto (CA)
- ORCID
- Bjerknes, Matthew
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 22
- Pages
- 12497-12502
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC60082
- OpenAlex
- W1987513354
- Cited by
- 325
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- glucagon-like peptide-2, GLP-2 receptor, enteric neurons, tetrodotoxin, voltage-gated sodium channels, gut-brain signaling
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Glucagon-Like Peptides, Intestinal Mucosa, Neurons, Peptides, Stem Cells, Tetrodotoxin, Genes, fos, Receptors, Glucagon, Mice, Glucagon-Like Peptide 2
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