The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria
Open accessAbstract
The SIR2 (silent information regulator 2) gene family has diverse functions in yeast including gene silencing, DNA repair, cell-cycle progression, and chromosome fidelity in meiosis and aging. Human homologues, termed sirtuins, are highly conserved but are of unknown function. We previously identified a large imprinted gene domain on 11p15.5 and investigated the 11p15.5 sirtuin SIRT3 . Although this gene was not imprinted, we found that it is localized to mitochondria, with a mitochondrial targeting signal within a unique N-terminal peptide sequence. The encoded protein was found also to possess NAD + -dependent histone deacetylase activity. These results suggest a previously unrecognized organelle for sirtuin function and that the role of SIRT3 in mitochondria involves protein deacetylation.
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Cites
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Cited by
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., & Horikawa, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0033 · Cited by 1,364
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295
Metadata
- Authors
- Onyango, P., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10-08
- Volume
- 99
- Issue
- 21
- Pages
- 13653-13658
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037678016
- Cited by
- 574
- References
- 2
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Onyango, P., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P. (2002). SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.222538099
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