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Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients
Open accessAbstract
The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alpha-MSH) and synthesizing neuropeptide Y, respectively. We report here that 42 of 57 (74%) AN andor BN patients studied had in their plasma Abs that bind to melanotropes andor corticotropes in the rat pituitary. Among these sera, 8 were found to bind selectively to alpha-MSH-positive neurons and their hypothalamic and extrahypothalamic projections as revealed with immunostaining on rat brain sections. Adsorption of these sera with alpha-MSH peptide abolished this immunostaining. In the pituitary, the immunostaining was blocked by adsorption with alpha-MSH or adrenocorticotropic hormone. Additionally, 3 ANBN sera bound to luteinizing hormone-releasing hormone (LHRH)-positive terminals in the rat median eminence, but only 2 of them were adsorbed with LHRH. In the control subjects, 2 of 13 sera (16%) displayed similar to ANBN staining. These data provide evidence that a significant subpopulation of ANBN patients have autoantibodies that bind to alpha-MSH or adrenocorticotropic hormone, a finding pointing also to involvement of the stress axis. It remains to be established whether these Abs interfere with normal signal transduction in the brain melanocortin circuitryLHRH system andor in other central and peripheral sites relevant to food intake regulation, to what extent such effects are related to andor could be involved in the pathophysiology or clinical presentation of ANBN, and to what extent increased stress is an important factor for production of these autoantibodies.
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“Autoantibodies directed against the peptide α-Melanocyte-stimulating hormone (α-MSH), which is involved in appetite control, have been discovered in both healthy individuals and in subjects with eating disorders (Fetissov et al., 2002;Fetissov et al., 2008).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fetissov et al., 2002
In the citing paper
“Fetissov and colleagues [45,46] revealed that a subgroup of patients with AN and BN had autoantibodies that bind to the α-melanocyte-stimulating hormone (MSH), and the circulating level of these autoantibodies was correlated with the psychological traits of eating disorders.”
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Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Bardawil, W. A., & Toy, B. L. (1969) · American Journal of Clinical Pathology · doi:10.1093/ajcp/52.1.99b · Cited by 1,566
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Elias, C. F., Lee, C., Kelly, J., Aschkenasi, C. J., Ahima, R. S., Couceyro, P. R., Kuhar, M. J., Saper, C. B., & Elmquist, J. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80656-x · Cited by 809
Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains.
Adams, J. C. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1527370 · Cited by 644
Molecular mimicry and immune‐mediated diseases
Oldstone, M. B. A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1255 · Cited by 594
Retardation of fading and enhancement of intensity of immunofluorescence by p-phenylenediamine.
Platt, J. L., & Michael, A. F. (1983) · Journal of Histochemistry & Cytochemistry · doi:10.1177/31.6.6341464 · Cited by 537
Research works printed but not linked: 1
- Coons A. H. (1958) in General Cytochemical Methods ed. Danielli J. F. (Academic New York) pp. 399–422.13574437
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Elaborate interactions between the immune and nervous systems
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Partinen, M., Kornum, B. R., Plazzi, G., Jennum, P., Julkunen, I., & Vaarala, O. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70075-4 · Cited by 282
Metadata
- Authors
- Fetissov, S. O., Hallman, J., Oreland, L., af Klinteberg, B., Grenbäck, E., Hulting, A.-L., & Hökfelt, T.
- Affiliations
- Departments of Neuroscience and Endocrinology, Karolinska Institute, SE-171 77 Stockholm, Sweden; Department of Neuroscience, Biomedical Center, SE-751 24 Uppsala, Sweden; and Department of Psychology, Stockholm University, SE-106 91 Stockholm, Sweden
- Uppsala University (SE)
- ORCID
- Hökfelt, Tomas
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-12-16
- Volume
- 99
- Issue
- 26
- Pages
- 17155-17160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC139285
- OpenAlex
- W2028553430
- Cited by
- 140
- References
- 39
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- autoantibodies, alpha-melanocyte-stimulating hormone, ACTH, gonadotropin-releasing hormone, anorexia nervosa, bulimia nervosa, eating disorders, hypothalamic arcuate nucleus, melanocortin system, neuropeptide Y, stress axis, pituitary gland, median eminence, food intake regulation
- MeSH terms
- Adolescent, Adrenocorticotropic Hormone, Adult, alpha-MSH, Animals, Anorexia, Autoantibodies, Bulimia, Female, Humans, Immunohistochemistry, Gonadotropin-Releasing Hormone, Male, Rats, Sprague-Dawley, Rats
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