Autoantibodies against neuropeptides are associated with psychological traits in eating disorders
Open accessAbstract
Previously, we identified that a majority of patients with anorexia nervosa (AN) and bulimia nervosa (BN) as well as some control subjects display autoantibodies (autoAbs) reacting with alpha-melanocyte-stimulating hormone (alpha-MSH) or adrenocorticotropic hormone, melanocortin peptides involved in appetite control and the stress response. In this work, we studied the relevance of such autoAbs to AN and BN. In addition to previously identified neuropeptide autoAbs, the current study revealed the presence of autoAbs reacting with oxytocin (OT) or vasopressin (VP) in both patients and controls. Analysis of serum levels of identified autoAbs showed an increase of IgM autoAbs against alpha-MSH, OT, and VP as well as of IgG autoAbs against VP in AN patients when compared with BN patients and controls. Further, we investigated whether levels of these autoAbs correlated with psychological traits characteristic for eating disorders. We found significantly altered correlations between alpha-MSH autoAb levels and the total Eating Disorder Inventory-2 score, as well as most of its subscale dimensions in AN and BN patients vs. controls. Remarkably, these correlations were opposite in AN vs. BN patients. In contrast, levels of autoAbs reacting with adrenocorticotropic hormone, OT, or VP had only few altered correlations with the Eating Disorder Inventory-2 subscale dimensions in AN and BN patients. Thus, our data reveal that core psychobehavioral abnormalities characteristic for eating disorders correlate with the levels of autoAbs against alpha-MSH, suggesting that AN and BN may be associated with autoAb-mediated dysfunctions of primarily the melanocortin system.
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A subgroup of patients with anorexia nervosa and bulimia nervosa had autoantibodies that bind to α-melanocyte-stimulating hormone, and the circulating level of these autoantibodies was correlated with psychological traits of eating disorders.
“Fetissov and colleagues [45,46] revealed that a subgroup of patients with AN and BN had autoantibodies that bind to the α-melanocyte-stimulating hormone (MSH), and the circulating level of these autoantibodies was correlated with the psychological traits of eating disorders.”
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“The latter may be particularly relevant to the pathogenesis and progression of eating disorders, as Fetissov and colleagues [45,46] revealed that a subgroup of patients with AN and BN had autoantibodies that bind to the α-melanocyte-stimulating hormone (MSH), and the circulating level of these autoantibodies was corre…”
BackgroundThe microbiota, the gut and the brain in eating and alcohol use disorders: A ‘Ménage à Trois’?
Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx024 · Cited by 76 · see citing works
- Authors
- Fetissov, S. O., Harro, J., Jaanisk, M., Järv, A., Podar, I., Allik, J., Nilsson, I., Sakthivel, P., Lefvert, A. K., & Hökfelt, T.
- Affiliations
- Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden; Department of Psychology, Centre of Behavioral and Health Sciences, University of Tartu, Tiigi 78, 50410 Tartu, Estonia; Psychiatry Clinic, Tartu University Hospital, Raja 31, 50417 Tartu, Estonia; and Immunological Research Laboratory, Center for Molecular Medicine and Department of Medicine, Karolinska Institutet, 17176 Stockholm, Sweden
- Tartu University Hospital (EE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-09-29
- Volume
- 102
- Issue
- 41
- Pages
- 14865-14870
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1253594
- OpenAlex
- W2091886883
- Cited by
- 152
- References
- 48
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 14 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 6
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- autoantibodies, neuropeptides, anorexia nervosa, bulimia nervosa, eating disorders, alpha-melanocyte-stimulating hormone, ACTH, melanocortin system, oxytocin, vasopressin, psychological characteristics, Eating Disorder Inventory-2, IgM autoantibodies, IgG autoantibodies
- MeSH terms
- Adult, Analysis of Variance, Anorexia Nervosa, Autoantibodies, Behavioral Symptoms, Enzyme-Linked Immunosorbent Assay, Estonia, Female, Humans, Immunohistochemistry, Melanocyte-Stimulating Hormones, Neuropeptides, Oxycodone, Vasopressins, Bulimia Nervosa
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