Elaborate interactions between the immune and nervous systems

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692 · see citing works

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works

The inflammatory reflex

Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964 · see citing works

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

Yednock, T. A., Cannon, C., Fritz, L. C., Sánchez‐Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737 · see citing works

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669 · see citing works

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

Youssef, S., Stüve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M., Mitchell, D. J., Sobel, R. A., Steinman, L., et al. (2002) · Nature · doi:10.1038/nature01158 · Cited by 1,098 · see citing works

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Carro, U. D., Amadio, S., Bergami, A., et al. (2003) · Nature · doi:10.1038/nature01552 · Cited by 1,071 · see citing works

Paraneoplastic Syndromes Involving the Nervous System

Darnell, R. B., & Posner, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023009 · Cited by 1,055 · see citing works

Autoimmune Response to Acetylcholine Receptor

Patrick, J., & Lindstrom, J. M. (1973) · Science · doi:10.1126/science.180.4088.871 · Cited by 1,049 · see citing works

Behaviorally Conditioned Immunosuppression

Ader, R., & Cohen, N. (1975) · Psychosomatic Medicine · doi:10.1097/00006842-197507000-00007 · Cited by 1,023 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

Responses of retinal rods to single photons.

Baylor, D. A., Lamb, T. D., & Yau, K. W. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012716 · Cited by 992 · see citing works

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

Steinhoff, M. S., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., et al. (2000) · Nature Medicine · doi:10.1038/72247 · Cited by 936 · see citing works

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

Chabas, D., Baranzini, S. E., Mitchell, D., Bernard, C. C. A., Rittling, S. R., Denhardt, D. T., Sobel, R. A., Lock, C., Karpuj, M., Pedotti, R., et al. (2001) · Science · doi:10.1126/science.1062960 · Cited by 829 · see citing works

Functional requirement for class I MHC in CNS development and plasticity

Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000) · Science · doi:10.1126/science.290.5499.2155 · Cited by 828 · see citing works

Direct observation of ligand recognition by T cells

Irvine, D. J., Purbhoo, M. A., Krogsgaard, M., & Davis, M. M. (2002) · Nature · doi:10.1038/nature01076 · Cited by 824 · see citing works

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 810 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

Lee, D. M., Friend, D. S., Gurish, M. F., Benoist, C. O., Mathis, D. J., & Brenner, M. B. (2002) · Science · doi:10.1126/science.1073176 · Cited by 751 · see citing works

THE INFLUENCE OF THE PROINFLAMMATORY CYTOKINE, OSTEOPONTIN, ON AUTOIMMUNE DEMYELINATING DISEASE

Chabas, D., Baranzini, S. E., Mitchell, D. J., Bernard, C. C. A., Rittling, S. R., Denhardt, D. T., Sobel, R. A., Lock, C., Karpuj, M. V., Pedotti, R., et al. (2002) · International Conference on Osteopontin and SIBLING Proteins · doi:10.1100/tsw.2002.326 · Cited by 729 · see citing works

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

Tracey, K. J., He, W., Manogue, K. R., Fong, Y., HESSE, D. G., Nguyen, H. T., Kuo, G. C., Beutler, B., Cotran, R. S., & Cerami, A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.1211 · Cited by 726 · see citing works

Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis

Rogers, S. W., Andrews, P. I., Gahring, L. C., Whisenand, T. D., Cauley, K. A., Crain, B. J., Hughes, T. E., Heinemann, S. F., & McNamara, J. O. (1994) · Science · doi:10.1126/science.8036512 · Cited by 684 · see citing works

Multiple sclerosis: a two-stage disease

Steinman, L. (2001) · Nature Immunology · doi:10.1038/ni0901-762 · Cited by 660 · see citing works

T-cell-antigen recognition and the immunological synapse

Huppa, J. B., & Davis, M. M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1245 · Cited by 640 · see citing works

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

Solimena, M., Folli, F. B., Aparisi, R., Pozza, G., & Camilli, P. V. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222202 · Cited by 623 · see citing works

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

Jutel, M., Watanabe, T., Klunker, S., Akdiş, M., Thomet, O. A. R., Małolepszy, J., Zak-Nejmark, T., Koga, R., Kobayashi, T., Blaser, K., et al. (2001) · Nature · doi:10.1038/35096564 · Cited by 587 · see citing works

TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases

Feldmann, M., & Maini, R. N. (2003) · Nature Medicine · doi:10.1038/nm939 · Cited by 586 · see citing works

Inflammatory processes in Alzheimer's disease

McGeer, E. G., & McGeer, P. L. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00124-6 · Cited by 473 · see citing works

Induction of MHC Class I Genes in Neurons

Neumann, H., Cavalié, A., Jenne, D. E., & Wekerle, H. (1995) · Science · doi:10.1126/science.7624779 · Cited by 449 · see citing works

Behaviorally Conditioned Immunosuppression and Murine Systemic Lupus Erythematosus

Ader, R., & Cohen, N. (1982) · Science · doi:10.1126/science.7063864 · Cited by 443 · see citing works

Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate Degradation

Drachman, D. B., Angus, C., Adams, R. N., et al. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805182982004 · Cited by 438 · see citing works

Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury

Woiciechowsky, C., Asadullah, K., Nestler, D., Eberhardt, B., Platzer, C., Schöning, B., Glöckner, F., Lanksch, W., Volk, H., & Döcke, W. (1998) · Nature Medicine · doi:10.1038/nm0798-808 · Cited by 435 · see citing works

Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help

Sanders, V. M., Baker, R. A., Ramer-Quinn, D. S., Kasprowicz, D. J., Fuchs, B. A., & Street, N. E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4200 · Cited by 434 · see citing works

T cell antigen receptors and the immunoglobulin supergene family

Hood, L. (1985) · Cell · doi:10.1016/0092-8674(85)90133-3 · Cited by 433 · see citing works

The TIM gene family: emerging roles in immunity and disease

Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., & Freeman, G. J. (2003) · Nature Reviews Immunology · doi:10.1038/nri1111 · Cited by 388 · see citing works

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

Karpuj, M., Becher, M., Springer, J. E., Chabas, D., Youssef, S., Pedotti, R., Mitchell, D., & Steinman, L. (2002) · Nature Medicine · doi:10.1038/nm0202-143 · Cited by 365 · see citing works

Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

Sanna, V., Giacomo, A. D., Cava, A. L., Lechler, R. I., Fontana, S., Zappacosta, S., & Matarese, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16721 · Cited by 360 · see citing works

Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems?

Goehler, L. E., Gaykema, R. P. A., Nguyen, K. T., Lee, J. E., Tilders, F. J. H., Maier, S. F., & Watkins, L. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02799.1999 · Cited by 357 · see citing works

Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis

Matarese, G., Giacomo, A. D., Sanna, V., Lord, G. M., Howard, J. K., Tuoro, A. D., Bloom, S. R., Lechler, R. I., Zappacosta, S., & Fontana, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.5909 · Cited by 353 · see citing works

Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2

Kumanogoh, A., Marukawa, S., Suzuki, K., Takegahara, N., Watanabe, C., Ch’ng, E. S., Ishida, I., Fujimura, H., Sakoda, S., Yoshida, K., et al. (2002) · Nature · doi:10.1038/nature01037 · Cited by 328 · see citing works

Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

Sanna, V., Giacomo, A. D., Cava, A. L., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316721 · Cited by 317 · see citing works

Substance P regulates the vasodilator activity of calcitonin gene-related peptide

Brain, S. D., & Williams, T. J. (1988) · Nature · doi:10.1038/335073a0 · Cited by 309 · see citing works

Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association with the M10 and M1 Families of MHC Class Ib Molecules

Loconto, J., Papes, F., Chang, E. C., Stowers, L., Jones, E. P., Takada, T., Kumánovics, A., Lindahl, K. F., & Dulac, C. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00153-3 · Cited by 295 · see citing works

Involvement of peripheral and central catecholamine systems in neural-immune interactions

Livnat, S., Felten, S. Y., Carlson, S. L., Bellinger, D. L., & Felten, D. L. (1985) · Journal of Neuroimmunology · doi:10.1016/0165-5728(85)90031-1 · Cited by 290 · see citing works

Neurotrophic cross‐talk between the nervous and immune systems: Implications for neurological diseases

Kerschensteiner, M., Stadelmann, C., Dechant, G., Wekerle, H., & Hohlfeld, R. (2003) · Annals of Neurology · doi:10.1002/ana.10446 · Cited by 273 · see citing works

Neural and Immunological Synaptic Relations

Dustin, M. L., & Colman, D. (2002) · Science · doi:10.1126/science.1076386 · Cited by 256 · see citing works

Regulation of leptin production: sympathetic nervous system interactions

Rayner, D. V., & Trayhurn, P. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100198 · Cited by 250 · see citing works

Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System

Villoslada, P., Hauser, S. L., Bartke, I., Unger, J. W., Heald, N., Rosenberg, D. P., Cheung, S. W., Mobley, W. C., Fisher, S., & Genain, C. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1799 · Cited by 233 · see citing works

Multiple Sclerosis: Deeper Understanding of Its Pathogenesis Reveals New Targets for Therapy

Steinman, L., Martinꝉ, R., Bernard, C. C. A., Conlon, P. J., & Oksenberg, J. R. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142913 · Cited by 230 · see citing works

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

Prinz, M., Heikenwälder, M. F., Junt, T., Schwarz, P., Glatzel, M., Heppner, F. L., Fu, Y., Lipp, M., & Aguzzi, A. (2003) · Nature · doi:10.1038/nature02072 · Cited by 217 · see citing works

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

Pedotti, R., Mitchell, D., Wedemeyer, J., Karpuj, M., Chabas, D., Hattab, E., Tsai, M., Galli, S., & Steinman, L. (2001) · Nature Immunology · doi:10.1038/85266 · Cited by 198 · see citing works

Combinatorial Coexpression of Neural and Immune Multigene Families in Mouse Vomeronasal Sensory Neurons

Ishii, T., Hirota, J., & Mombaerts, P. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00092-7 · Cited by 175 · see citing works

Lack of isoprenoid products raises ex vivo interleukin‐1β secretion in hyperimmunoglobulinemia D and periodic fever syndrome

Frenkel, J., Rijkers, G. T., Mandey, S. H. L., Buurman, S. W. M., Houten, S. M., Wanders, R. J. A., Waterham, H. R., & Kuis, W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10550 · Cited by 170 · see citing works

Prostaglandins as inflammatory messengers across the blood-brain barrier

Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167 · see citing works

A synaptic basis for T-lymphocyte activation

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Mast cells in autoimmune disease

Benoist, C., & Mathis, D. (2002) · Nature · doi:10.1038/nature01324 · Cited by 163 · see citing works

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis.

Zamvil, S., & Steinman, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00326-x · Cited by 163 · see citing works

Noradrenergic Sympathetic Innervation of Lymphoid Organs1

Felten, S. Y., Felten, D. L., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowka, J. A., & Livnat, S. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000416168 · Cited by 161 · see citing works

Stress-induced enhancement of skin immune function: A role for γ interferon

Dhabhar, F. S., Satoskar, A. R., Bluethmann, H., David, J. R., & McEwen, B. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050569397 · Cited by 156 · see citing works

α-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice

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Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion

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Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

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Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients

Fetissov, S. O., Hallman, J., Oreland, L., af Klinteberg, B., Grenbäck, E., Hulting, A.-L., & Hökfelt, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222658699 · Cited by 140 · see citing works

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination

Pedotti, R., DeVoss, J., Youssef, S., Mitchell, D., Wedemeyer, J., Madanat, R., Garren, H., Fontoura, P., Tsai, M., Galli, S., et al. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.252777399 · Cited by 138 · see citing works

Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease Course

TANZOLA, M., Robbie‐Ryan, M., Gutekunst, C. A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4385 · Cited by 127 · see citing works

Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases

Pedotti, R., Voss, J. J. D., Steinman, L., & Galli, S. J. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00233-3 · Cited by 126 · see citing works

Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor

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Experimental Autoimmune Myasthenia Gravis: A Sequential and Quantitative Study of the Neuromuscular Junction Ultrastructure and Electrophysiologic Correlations

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Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti‐neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration

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Stiff-man syndrome in a woman with breast cancer

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Stress and autoimmunity: the neuropeptides corticotropin-releasing factor and urocortin suppress encephalomyelitis via effects on both the hypothalamic-pituitary-adrenal axis and the immune system

Poliak, S., Mor, F., Conlon, P. J., Wong, T., LING, N. C., Rivier, J., Vale, W., & Steinman, L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5751 · Cited by 86 · see citing works

Roles of Vasoactive Intestinal Peptide (VIP) in the Expression of Different Immune Phenotypes by Wild-Type Mice and T Cell-Targeted Type II VIP Receptor Transgenic Mice

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Corticotropin releasing hormone (CRH) antagonist attenuates adjuvant induced arthritis: role of CRH in peripheral inflammation.

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Expression of T cell receptor βlocus in central nervous system neurons

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IMMUNOPHARMACOLOGICAL DISEASE: A BREAK IN TOLERANCE TO RECEPTOR SITES

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Norepinephrine from synovial tyrosine hydroxylase positive cells is a strong indicator of synovial inflammation in rheumatoid arthritis.

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Intracerebroventricular interleukin-6, macrophage inflammatory protein-1β and IL-18: pyrogenic and PGE2-mediated?

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Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: possible relevance to multiple sclerosis

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Neural Control of Ocular Immune Privilege

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Endogenous Interleukin‐10 is Required for the Defervescence of Fever Evoked by Local Lipopolysaccharide‐Induced and Staphylococcus Aureus‐Induced Inflammation in Rats

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Connections between the immune system and the nervous system.

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Cutting Edge: Vasoactive Intestinal Peptide Acts as a Potent Suppressor of Inflammation In Vivo by Trans -Deactivating Chemokine Receptors

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The intricate interplay among body weight, stress, and the immune response to friend or foe

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The intricate interplay among body weight, stress, and the immune response to friend or foe

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Effect of Glucagon on Glucose Production, Lipolysis, and Gluconeogenesis in Familial Hyperinsulinism

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Experimental autoimmune myasthenia gravis.

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Prospects for specific immunotherapy in myasthenia gravis

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