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Disrupted synaptic development in the hypoxic newborn brain
Open accessAbstract
Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with immunohistochemical and protein assays, reveals that sublethal hypoxia accentuates genes subserving presynaptic function, and it suppresses genes involved with synaptic maturation, postsynaptic function, and neurotransmission. Other significantly affected pathways include those involved with glial maturation, vasculogenesis, and components of the cortical and microtubular cytoskeleton. These patterns reveal a global dysynchrony in the maturation programs of the hypoxic developing brain, and offer insights into the vulnerabilities of processes that guide early postnatal cerebral maturation.
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“it was shown in an animal models that the most significant pathology of the extremely premature brain is the disruption of synaptic development.99”
From Autism risk factors: genes, environment, and gene-environment interactions (2012) · cites this paper as [99]
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Metadata
- Authors
- Curristin, S. M., Cao, A., Stewart, W. B., Zhang, H., Madri, J. A., Morrow, J. S., & Ment, L. R.
- Affiliations
- Yale University (US)
- Departments of Pathology, Epidemiology and Public Health, Surgery, Pediatrics, and Neurology, Yale University School of Medicine, New Haven, CT 06510
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-11-15
- Volume
- 99
- Issue
- 24
- Pages
- 15729-15734
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC137784
- OpenAlex
- W2168015911
- Cited by
- 125
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20ns032578-03, 5r21ns042238-02, 5p01dk038979-05)
- National Heart, Lung, and Blood Institute (T32-HL 07778, T32HL007778)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 38979)
- National Institute of Neurological Disorders and Stroke (NS-35476, NS-27116, R01NS027116, NS32578, P01NS035476, NS42238)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neonatal brain, synaptic development, preterm infants, cognitive disability, presynaptic function, postsynaptic function, neurotransmission, glial maturation, vasculogenesis, cytoskeleton, transcriptome, mouse model
- MeSH terms
- Animals, Animals, Newborn, Hypoxia, Atmosphere Exposure Chambers, Brain Damage, Chronic, Cell Differentiation, Hypoxia, Brain, Cytoskeleton, Disease Models, Animal, Lymphokines, Membrane Proteins, Mice, Inbred C57BL, Microtubules, Nerve Tissue Proteins, Synaptic Transmission, Oligodendroglia, Stress, Physiological, Synapses, Transcription Factors, Transcription, Genetic, Endothelial Growth Factors, Apoptosis, DNA, Complementary, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
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