Reelin glycoprotein: structure, biology and roles in health and disease
Abstract
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.
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Decreased Reelin expression has been observed in the PFC, hippocampus, and cerebellum, as well as in blood of subjects with bipolar disorder or major depression.
“For instance, decreased Reelin expression has been observed in the PFC, hippocampus, and cerebellum, as well as in blood of subjects with bipolar disorder or major depression (Guidotti et al., 2000a;Fatemi, 2005).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Fatemi, 2005
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“1 Reelin protein product has a relative molecular mass of 388 kDa”
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- Authors
- Fatemi, S. H.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Fatemi, S H
- ORCID
- Fatemi, S H
- Venue
- Molecular Psychiatry
- Published
- 2004-12-07
- Volume
- 10
- Issue
- 3
- Pages
- 251-257
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2106633628
- Cited by
- 241
- References
- 9
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 18 · 2015: 13 · 2014: 13 · 2013: 17 · 2012: 13
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- reelin, RELN gene, serine protease, neuronal migration, radial glia, brain development, synaptic plasticity, memory formation, cognitive impairment, autism spectrum disorder, schizophrenia, promoter hypermethylation, epigenetics, neuropsychiatric disorders
- MeSH terms
- Reelin Protein, Animals, Autistic Disorder, Humans, Mice, Neurologic Mutants, Nerve Tissue Proteins, Schizophrenia, Serine Endopeptidases, Signal Transduction, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice
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