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Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland
Open accessAbstract
The thyroid-stimulating hormone/thyrotropin (TSH) is the most relevant hormone in the control of thyroid gland physiology in adulthood. TSH effects on the thyroid gland are mediated by the interaction with a specific TSH receptor (TSHR). We studied the role of TSH/TSHR signaling on gland morphogenesis and differentiation in the mouse embryo using mouse lines deprived either of TSH ( pit dw / pit dw ) or of a functional TSHR ( tshr hyt / tshr hyt and TSHR -knockout lines). The results reported here show that in the absence of either TSH or a functional TSHR, the thyroid gland develops to a normal size, whereas the expression of thyroperoxidase and the sodium/iodide symporter are reduced greatly. Conversely, no relevant changes are detected in the amounts of thyroglobulin and the thyroid-enriched transcription factors TTF-1, TTF-2, and Pax8. These data suggest that the major role of the TSH/TSHR pathway is in controlling genes involved in iodide metabolism such as sodium/iodide symporter and thyroperoxidase. Furthermore, our data indicate that in embryonic life TSH does not play an equivalent role in controlling gland growth as in the adult thyroid.
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Citations
Cited by
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
De Felice, M., & Di Lauro, R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 659
Self-citationGenetics of congenital hypothyroidism
Park, S. M., & Chatterjee, V. K. K. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024158 · Cited by 403
Generation of functional thyroid from embryonic stem cells
Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., et al. (2012) · Nature · doi:10.1038/nature11525 · Cited by 359
Molecular Pathogenesis of Euthyroid and Toxic Multinodular Goiter
Krohn, K., Führer, D., Bayer, Y., Eszlinger, M., Brauer, V., Neumann, S., Paschke, R., & Führer-Sakel, D. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0005 · Cited by 318
Development of the thyroid gland
Nilsson, M., & Fagman, H. (2017) · Development · doi:10.1242/dev.145615 · Cited by 286
Metadata
- Authors
- Postiglione, M. P., Parlato, R., Rodriguez-Mallon, A., Rosica, A., Mithbaokar, P., Maresca, M., Marians, R. C., Davies, T. F., Zannini, M. S., De Felice, M., & Di Lauro, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-11-13
- Volume
- 99
- Issue
- 24
- Pages
- 15462-15467
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2149022414
- Cited by
- 251
- References
- 0
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Postiglione, M. P., Parlato, R., Rodriguez-Mallon, A., Rosica, A., Mithbaokar, P., Maresca, M., Marians, R. C., Davies, T. F., Zannini, M. S., De Felice, M., & Di Lauro, R. (2002). Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.242328999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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