The DOI matches its Crossref record; 234 of the 234 references it cites were found in a registry or an index.
Molecular Pathogenesis of Euthyroid and Toxic Multinodular Goiter
Abstract
The purpose of this review is to summarize current knowledge of the etiology of euthyroid and toxic multinodular goiter (MNG) with respect to the epidemiology, clinical characteristics, and molecular pathology. In reconstructing the line of events from early thyroid hyperplasia to MNG we will argue the predominant neoplastic character of nodular structures, the nature of known somatic mutations, and the importance of mutagenesis. Furthermore, we outline direct and indirect consequences of these somatic mutations for thyroid pathophysiology and summarize information concerning a possible genetic background of euthyroid goiter. Finally, we discuss uncertainties and open questions in differential diagnosis and therapy of euthyroid and toxic MNG.
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Citations
Cites
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“E-mail: pasr@medizin.uni-leipzig.de This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG/Pa423/3-2 and Pa423/12-1; NE 84417-7, FU 35617- 7), the Krebshilfe (10-1575), and the Interdisziplinäres Zentrum für Klinische Forschung at the Faculty of Medicine of the University of Leipzig (Project…”
BackgroundMethodPendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)
Everett, L. A., Glaser, B., Beck, J. C., Idol, J. R., Buchs, A., Heyman, M., Adawi, F., Hazani, E., Nassir, E., Baxevanis, A. D., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-411 · Cited by 1,144
Thyroid Cancer after Exposure to External Radiation: A Pooled Analysis of Seven Studies
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., Schneider, A. B., Tucker, M. A., & Boice, J. D. (2012) · Radiation Research · doi:10.1667/rrav05.1 · Cited by 1,124
Thyroid Cancer after Exposure to External Radiation: A Pooled Analysis of Seven Studies
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., Schneider, A. B., Tucker, M. A., & Boice, J. D. (1995) · Radiation Research · doi:10.2307/3579003 · Cited by 1,107 · cited 2×
“E-mail: pasr@medizin.uni-leipzig.de This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG/Pa423/3-2 and Pa423/12-1; NE 84417-7, FU 35617- 7), the Krebshilfe (10-1575), and the Interdisziplinäres Zentrum für Klinische Forschung at the Faculty of Medicine of the University of Leipzig (Project…”
Method
Cited by
Overview of the 2022 WHO Classification of Thyroid Neoplasms
Baloch, Z. W., Asa, S. L., Barletta, J. A., Ghossein, R. A., Juhlin, C. C., Jung, C. K., LiVolsi, V. A., Papotti, M. G., Sobrinho-Simões, M., Tallini, G., et al. (2022) · Endocrine Pathology · doi:10.1007/s12022-022-09707-3 · Cited by 1,158
Iodine deficiency and thyroid disorders
Zimmermann, M. B., & Boelaert, K. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70225-6 · Cited by 930
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Kondo, T., Ezzat, S., & Asa, S. L. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1836 · Cited by 893
Iodine intake as a determinant of thyroid disorders in populations
Laurberg, P., Cerqueira, C., Ovesen, L., Rasmussen, L. B., Perrild, H., Andersen, S., Pedersen, I. B., & Carlé, A. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.08.013 · Cited by 507
Thyroxine in Goiter, Helicobacter pylori Infection, and Chronic Gastritis
Centanni, M., Gargano, L., Canettieri, G., Viceconti, N., Franchi, A., Fave, G. D., & Annibale, B. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa043903 · Cited by 329
Metadata
- Authors
- Krohn, K., Führer, D., Bayer, Y., Eszlinger, M., Brauer, V., Neumann, S., Paschke, R., & Führer-Sakel, D.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-12-22
- Volume
- 26
- Issue
- 4
- Pages
- 504-524
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1999353400
- Cited by
- 318
- References
- 234
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krohn, K., Führer, D., Bayer, Y., Eszlinger, M., Brauer, V., Neumann, S., Paschke, R., & Führer-Sakel, D. (2005). Molecular Pathogenesis of Euthyroid and Toxic Multinodular Goiter. Endocrine Reviews. https://doi.org/10.1210/er.2004-0005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
