The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Adoptive T cell therapy using antigen-specific CD8+T cell clones for the treatment of patients with metastatic melanoma:In vivo persistence, migration, and antitumor effect of transferred T cells
Open accessAbstract
Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety,in vivo persistence, and efficacy of adoptively transferred CD8+T cell clones targeting the tumor-associated antigens, MART1/MelanA and gp100 for the treatment of patients with metastatic melanoma. Four infusions of autologous T cell clones were administered, the first without IL-2 and subsequent infusions with low-dose IL-2 (at 0.25, 0.50, and 1.0 × 10 6 units/m 2 twice daily for the second, third, and fourth infusions, respectively). Forty-three infusions of MART1/MelanA-specific or gp100-specific CD8+T cell clones were administered to 10 patients. No serious toxicity was observed. We demonstrate that the adoptively transferred T cell clones persist in vivo in response to low-dose IL-2, preferentially localize to tumor sites and mediate an antigen-specific immune response characterized by the elimination of antigen-positive tumor cells, regression of individual metastases, and minor, mixed or stable responses in 8 of 10 patients with refractory, metastatic disease for up to 21 mo.
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Engineered T cells: the promise and challenges of cancer immunotherapy
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Metadata
- Authors
- Yee, C., Thompson, J. A., Byrd, D., Riddell, S. R., Roche, P., Celis, E., & Greenberg, P. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-11-11
- Volume
- 99
- Issue
- 25
- Pages
- 16168-16173
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016671320
- Cited by
- 1,206
- References
- 27
- FWCI
- 21.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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