Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Abstract
Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
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TRM cells are the most recently identified subset of memory T cells, initially characterized as effector memory T cells with a preference for residing in nonlymphoid tissues.
“Tissue-resident memory (T RM ) cells are the most recently identified subset of memory T cells, initially characterized as effector memory T cells with a preference for residing in nonlymphoid tissues. 287-289”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [287]
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“This contention is at odds with clear and elegant experiments in mice showing that TEM do persist long term — not in the blood but within the peripheral tissues (Masopust et al., 2001; Reinhardt et al., 2001).”
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- Authors
- Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L.
- Affiliations
- UConn Health (US)
- Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
- Venue
- Science
- Published
- 2001-03-23
- Volume
- 291
- Issue
- 5512
- Pages
- 2413-2417
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081097093
- Cited by
- 1,952
- References
- 0
- Citations by year
- 2026: 23 · 2025: 42 · 2024: 39 · 2023: 36 · 2022: 52 · 2021: 55 · 2020: 67 · 2019: 71 · 2018: 76 · 2017: 65 · 2016: 52 · 2015: 53 · 2014: 69 · 2013: 80 · 2012: 60
- FWCI
- 42.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI41576, T32 AI 07080, R01AI041576, T32AI007080)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK45260, R01DK045260)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- effector memory T cells, non-lymphoid tissues, CD8+ T cells, T cell migration, intracellular pathogens, viral infection, bacterial infection, lytic activity
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Flow Cytometry, H-2 Antigens, Immunologic Memory, Intestine, Small, Listeriosis, Listeria monocytogenes, Liver, Lung, Lymphocyte Activation, Lymphoid Tissue, Mice, Inbred C57BL, Ovalbumin, Phenotype, Vesicular stomatitis Indiana virus, T-Lymphocyte Subsets, Rhabdoviridae Infections, CD8-Positive T-Lymphocytes, Mice
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