The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Regulation of survivin function by Hsp90
Open accessAbstract
Pathways controlling cell proliferation and cell survival require flexible adaptation to environmental stresses. These mechanisms are frequently exploited in cancer, allowing tumor cells to thrive in unfavorable milieus. Here, we show that Hsp90, a molecular chaperone that is central to the cellular stress response, associates with survivin, an apoptosis inhibitor and essential regulator of mitosis. This interaction involves the ATPase domain of Hsp90 and the survivin baculovirus inhibitor of apoptosis repeat. Global suppression of the Hsp90 chaperone function or targeted Abmediated disruption of the survivin–Hsp90 complex results in proteasomal degradation of survivin, mitochondrial-dependent apoptosis, and cell cycle arrest with mitotic defects. These data link the cellular stress response to an antiapoptotic and mitotic checkpoint maintained by survivin. Targeting the survivin–Hsp90 complex may provide a rational approach for cancer therapy.
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Cites
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Self-citationSteroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
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Self-citationApaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
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Cited by
Menyhárt, O., Nagy, Á., & Győrffy, B. (2018) · Royal Society Open Science · doi:10.1098/rsos.181006 · Cited by 507
Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches
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Survivin, a cancer target with an emerging role in normal adult tissues
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An IAP-IAP Complex Inhibits Apoptosis
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Self-citationSurvivin and IAP proteins in cell-death mechanisms
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Metadata
- Authors
- Fortugno, P., Beltrami, E., Plescia, J., Fontana, J., Pradhan, D., Marchisio, P. C., Sessa, W. C., & Altieri, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-12
- Volume
- 100
- Issue
- 24
- Pages
- 13791-13796
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986088839
- Cited by
- 318
- References
- 34
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Fortugno, P., Beltrami, E., Plescia, J., Fontana, J., Pradhan, D., Marchisio, P. C., Sessa, W. C., & Altieri, D. C. (2003). Regulation of survivin function by Hsp90. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2434345100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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