The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients
Open accessAbstract
Pathogenetic processes that facilitate the entry, replication, and persistence of Mycobacterium tuberculosis(MTB) in the mammalian host likely include the regulated expression of specific sets of genes at different stages of infection. Identification of genes that are differentially expressed in vivo would provide insights into host-pathogen interactions in tuberculosis (TB); this approach might be particularly valuable for the study of human TB, where experimental opportunities are limited. In this study, the levels of selected MTB mRNAs were quantified in vitro in axenic culture,in vivo in the lungs of mice, and in lung specimens obtained from TB patients with active disease. We report the differential expression of MTB mRNAs associated with iron limitation, alternative carbon metabolism, and cellular hypoxia, conditions that are thought to exist within the granulomatous lesions of TB, in the lungs of wild-type C57BL/6 mice as compared with bacteria grown in vitro. Analysis of the same set of mRNAs in lung specimens obtained from TB patients revealed differences in MTB gene expression in humans as compared with mice.
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Cites
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Cited by
Schaible, U. E., & Kaufmann, S. H. E. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1046 · Cited by 945
Persistent bacterial infections: the interface of the pathogen and the host immune system
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The Enduring Hypoxic Response of Mycobacterium tuberculosis
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Tuberculosis — metabolism and respiration in the absence of growth
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Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum
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Metadata
- Authors
- Timm, J., Post, F. A., Bekker, L.-G., Walther, G. B., Wainwright, H. C., Manganelli, R., Chan, W.-T., Tsenova, L., Gold, B., Smith, I., Kaplan, G., & McKinney, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-17
- Volume
- 100
- Issue
- 24
- Pages
- 14321-14326
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043952643
- Cited by
- 279
- References
- 9
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. https://app.cochat.ai/papers/10.1073/pnas.2436197100
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- Timm, J., Post, F. A., Bekker, L.-G., Walther, G. B., Wainwright, H. C., Manganelli, R., Chan, W.-T., Tsenova, L., Gold, B., Smith, I., Kaplan, G., & McKinney, J. D. (2003). Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2436197100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
